Dexmedetomidine post-conditioning alleviates myocardial ischemia–reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation

System Xc−: a key regulatory target of ferroptosis in cancer

(2021) Man-ru Liu et al.   INVESTIGATIONAL NEW DRUGS

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Dexmedetomidine reduces the inflammation and apoptosis of doxorubicin-induced myocardial cells

(2020) Ying He et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

(2020) Chunyan Wang et al.   Molecular Medicine Reports

Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1

(2020) Hui Dong et al.   Aging-US

Dexmedetomidine pretreatment protects the heart against apoptosis in ischemia/reperfusion injury in diabetic rats by activating PI3K/Akt signaling in vivo and in vitro

(2020) Jian-Hua Chang et al.   BIOMEDICINE & PHARMACOTHERAPY

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Dexmedetomidine inhibits pyroptosis by down-regulating miR-29b in myocardial ischemia reperfusion injury in rats

(2020) Yi Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway

(2020) Liang He et al.   BIOMEDICINE & PHARMACOTHERAPY

Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils

(2020) Xue Guan et al.   LIFE SCIENCES

Dexmedetomidine Protects against Myocardial Ischemia/Reperfusion Injury by Ameliorating Oxidative Stress and Cell Apoptosis through the Trx1-Dependent Akt Pathway

(2020) Zhi-lin Wu et al.   Biomed Research International

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia–reperfusion injury

(2019) Tarja Alakoski et al.   BASIC RESEARCH IN CARDIOLOGY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis

(2019) Yue Gong et al.   DNA AND CELL BIOLOGY

Dexmedetomidine protects against lung injury induced by limb ischemia‐reperfusion via the TLR4/MyD88/NF‐κB pathway

(2019) Bin‐Bin Xue et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Dexmedetomidine post‐treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF‐1α signalling

(2019) Ke Peng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes

(2019) Natticha Sumneang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dexmedetomidine Protects SK-N-SH Nerve Cells from Oxidative Injury by Maintaining Iron Homeostasis

(2019) Lingqin Qiu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

To eat or not to eat — the metabolic flavor of ferroptosis

(2018) Minghui Gao et al.   CURRENT OPINION IN CELL BIOLOGY

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Dexmedetomidine and Renal Protection after Cardiac Surgery

(2017) Sohail K. Mahboobi   JOURNAL OF CLINICAL ANESTHESIA

Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells

(2017) Shihui Hao et al.   NEOPLASIA

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting

(2015) Gillian M. Keating   DRUGS

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Antioxidants and human diseases

(2014) Peramaiyan Rajendran et al.   CLINICA CHIMICA ACTA

Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart

(2012) Mauricio Ibacache et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Direct Protective Effects of Dexmedetomidine Against Myocardial Ischemia-Reperfusion Injury in Anesthetized Pigs

(2012) Osamu Yoshitomi et al.   SHOCK

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Dexmedetomidine Use in General Anaesthesia

(2009) A. Arcangeli et al.   CURRENT DRUG TARGETS