The Translational Potential of Microglia and Monocyte-Derived Macrophages in Ischemic Stroke

Persistent inflammation worsens short-term outcomes in massive stroke patients

(2021) Duanlu Hou et al.   BMC Neurology

Microglial/Macrophage polarization and function in brain injury and repair after stroke

(2021) Junxuan Lyu et al.   CNS Neuroscience & Therapeutics

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats

(2021) Lin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke

(2021) Jie Xu et al.   STROKE

Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia

(2021) Bhakta Prasad Gaire   CELLULAR AND MOLECULAR NEUROBIOLOGY

Annexin A1 protects against cerebral ischemia–reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway

(2021) Xin Xu et al.   Journal of Neuroinflammation

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery

(2021) Fang Yu et al.   Frontiers in Cellular Neuroscience

Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation

(2021) Jiping Li et al.   Frontiers in Pharmacology

Effects of Microglial Activation and Polarization on Brain Injury After Stroke

(2021) Rui Dong et al.   Frontiers in Neurology

Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia

(2021) Joanna M Wierońska et al.   Biomolecules

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2021) Valery L Feigin et al.   LANCET NEUROLOGY

Stroke recovery enhancing therapies: lessons from recent clinical trials

(2021) Andreas Rogalewski et al.   Neural Regeneration Research

Regulation of myelination by microglia

(2021) Erin N. Santos et al.   Science Advances

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Modulators of microglia activation and polarization in ischemic stroke (Review)

(2020) Cheng‑Ting Jiang et al.   Molecular Medicine Reports

Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

(2020) Yves Werner et al.   NATURE NEUROSCIENCE

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

VCAM1/VLA4 interaction mediates Ly6Clow monocyte recruitment to the brain in a TNFR signaling dependent manner during fungal infection

(2020) Donglei Sun et al.   PLoS Pathogens

Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells

(2020) Denisa Belov Kirdajova et al.   Frontiers in Cellular Neuroscience

Edaravone-Loaded Macrophage-Derived Exosomes Enhance Neuroprotection in the Rat Permanent Middle Cerebral Artery Occlusion Model of Stroke

(2020) Fang Li et al.   MOLECULAR PHARMACEUTICS

Microglia and Their Promising Role in Ischemic Brain Injuries: An Update

(2020) Luting Yu et al.   Frontiers in Cellular Neuroscience

Overview of General and Discriminating Markers of Differential Microglia Phenotypes

(2020) Agnieszka M. Jurga et al.   Frontiers in Cellular Neuroscience

Macrophages and the maintenance of homeostasis

(2020) David M. Mosser et al.   Cellular & Molecular Immunology

FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages

(2020) Dongxue Wang et al.   Journal of Neuroinflammation

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

(2020) Tim Bartels et al.   SCIENCE

Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?

(2020) Joohyun Park et al.   Frontiers in Neurology

The novel Nrf2 activator CDDO‐EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice

(2020) Xia Lei et al.   CNS Neuroscience & Therapeutics

Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis

(2020) Stefano Raffaele et al.   MOLECULAR THERAPY

PD-1+ Monocytes Mediate Cerebral Vasospasm Following Subarachnoid Hemorrhage

(2020) Christopher M Jackson et al.   NEUROSURGERY

Neutrophils and Macrophages as Targets for Development of Nanotherapeutics in Inflammatory Diseases

(2020) Yujie Su et al.   Pharmaceutics

In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay

(2019) Daniel Schulz et al.   Scientific Reports

Clinical Effects of Early Edaravone Use in Acute Ischemic Stroke Patients Treated by Endovascular Reperfusion Therapy

(2019) Masaya Enomoto et al.   STROKE

Angiogenesis in the ischemic core: A potential treatment target?

(2019) Masato Kanazawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy

(2019) Zurab Nadareishvili et al.   CEREBROVASCULAR DISEASES

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation

(2019) Xili Chu et al.   Journal of Neuroinflammation

Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug

(2019) Paolo Gelosa et al.   PHARMACOLOGICAL RESEARCH

Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery

(2019) Rafał Szelenberger et al.   Current Neuropharmacology

Neuroinflammation: friend and foe for ischemic stroke

(2019) Richard L. Jayaraj et al.   Journal of Neuroinflammation

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke

(2019) Natalia Kolosowska et al.   Neurotherapeutics

Phagocytosis in the Brain: Homeostasis and Disease

(2019) Dylan A. Galloway et al.   Frontiers in Immunology

MicroRNAs as Molecular Switches in Macrophage Activation

(2019) Graziella Curtale et al.   Frontiers in Immunology

Glucocorticoid Therapy of Multiple Sclerosis Patients Induces Anti-inflammatory Polarization and Increased Chemotaxis of Monocytes

(2019) Henrike J. Fischer et al.   Frontiers in Immunology

Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2+ Proinflammatory Subset

(2019) Jiwon Yang et al.   JOURNAL OF NEUROSCIENCE

Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases

(2019) Theodore S. Kapellos et al.   Frontiers in Immunology

Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain

(2019) Wenting Zhang et al.   CNS Neuroscience & Therapeutics

Pathology of inflammatory diseases of the nervous system: Human disease versus animal models

(2019) Hans Lassmann   GLIA

Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders

(2019) Samuel F. Yanuck   Frontiers in Psychiatry

Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

(2019) Yingze Ye et al.   Frontiers in Cellular Neuroscience

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia

(2019) Takashi Koizumi et al.   Frontiers in Neuroscience

Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

(2019) Thecla A. van Wageningen et al.   Acta Neuropathologica Communications

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Role of Inflammation in Neurological Disorders

(2018) Diana Degan et al.   CURRENT PHARMACEUTICAL DESIGN

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

(2018) Shan Huang et al.   FASEB JOURNAL

Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures

(2018) Joanna Ślusarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

(2018) Wei Cai et al.   PROGRESS IN NEUROBIOLOGY

CCR2-dependent monocytes/macrophages exacerbate acute brain injury but promote functional recovery after ischemic stroke in mice

(2018) Weirong Fang et al.   Theranostics

Sex-Specific Features of Microglia from Adult Mice

(2018) Alessandro Villa et al.   Cell Reports

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

(2018) Fangfang Li et al.   CNS & Neurological Disorders-Drug Targets

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

(2018) Andrew D. Greenhalgh et al.   PLOS BIOLOGY

Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model

(2017) Roya Aryanpour et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

(2017) Ruimin Ge et al.   Journal of Neuroinflammation

Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors

(2017) Jenni E. Anttila et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

(2017) Chuan Qin et al.   STROKE

Minocycline in Acute Cerebral Hemorrhage

(2017) Abdelrahman Y. Fouda et al.   STROKE

Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke

(2017) Antje Schmidt et al.   STROKE

NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

(2017) Jing Ji et al.   Frontiers in Cellular Neuroscience

Minocycline modulates microglia polarization in ischemia-reperfusion model of retinal degeneration and induces neuroprotection

(2017) Amel Ahmed et al.   Scientific Reports

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

(2017) Stephanie A. Amici et al.   Frontiers in Immunology

Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation

(2016) Francesc Miró-Mur et al.   BRAIN BEHAVIOR AND IMMUNITY

Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice

(2016) Zhao-Ma Shu et al.   CNS Neuroscience & Therapeutics

Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling

(2016) Yating He et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice

(2016) Yuanyuan Ma et al.   Journal of Neuroinflammation

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

(2016) Lidia Garcia-Bonilla et al.   Journal of Neuroinflammation

Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages

(2016) Ranran Han et al.   Journal of Neuroinflammation

Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

(2016) Raffaella Moretti et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Sex differences in neuroinflammation and neuroprotection in ischemic stroke

(2016) Monica S. Spychala et al.   JOURNAL OF NEUROSCIENCE RESEARCH

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

The Role of Monocytes in Ischemic Stroke Pathobiology: New Avenues to Explore

(2016) Ayman ElAli et al.   Frontiers in Aging Neuroscience

Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE

(2015) Zilong Zhu et al.   CIRCULATION

Functional differences between microglia and monocytes after ischemic stroke

(2015) Rodney M. Ritzel et al.   Journal of Neuroinflammation

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

(2015) K. P. Doyle et al.   JOURNAL OF NEUROSCIENCE

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

The dynamics of monocytes and microglia in Alzheimer’s disease

(2015) Peter Thériault et al.   Alzheimers Research & Therapy

An open-label evaluator-blinded clinical study of minocycline neuroprotection in ischemic stroke: gender-dependent effect

(2014) Mohammad Reza Amiri-Nikpour et al.   ACTA NEUROLOGICA SCANDINAVICA

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

The journey from stem cell to macrophage

(2014) Mikael J. Pittet et al.   Annals of the New York Academy of Sciences

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

(2014) Ingo Hilgendorf et al.   CIRCULATION RESEARCH

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Microglia is a Key Player in the Reduction of Stroke Damage Promoted by the New Antithrombotic Agent Ticagrelor

(2014) Paolo Gelosa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Impact of Ly6Clow Monocytes after Cerebral Hypoxia-Ischemia in Adult Mice

(2014) Jean-Philippe Michaud et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Spleen-Derived Monocytes/Macrophages in Acute Ischemic Brain Injury

(2014) Eunhee Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

(2014) Zhiwei Tang et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

CCR2+Ly6Chi Inflammatory Monocyte Recruitment Exacerbates Acute Disability Following Intracerebral Hemorrhage

(2014) M. D. Hammond et al.   JOURNAL OF NEUROSCIENCE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

The Monocyte to Macrophage Transition in the Murine Sterile Wound

(2014) Meredith J. Crane et al.   PLoS One

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Drug Treatment of Acute Ischemic Stroke

(2013) Sameer Bansal et al.   American Journal of Cardiovascular Drugs

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Relevance of Distinct Monocyte Subsets to Clinical Course of Ischemic Stroke Patients

(2013) Muichi Kaito et al.   PLoS One

Intravenous Minocycline in Acute Stroke

(2013) Edith Kohler et al.   STROKE

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

(2012) Michael Gliem et al.   ANNALS OF NEUROLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

(2012) Ann M Stowe et al.   Journal of Neuroinflammation

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb

(2012) Martin Etzrodt et al.   Cell Reports

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

Toll-like receptors in cerebral ischemic inflammatory injury

(2011) Yan-Chun Wang et al.   Journal of Neuroinflammation

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Minocycline to Improve Neurologic Outcome in Stroke (MINOS)

(2010) Susan C. Fagan et al.   STROKE

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

The role of microglia in central nervous system immunity and glioma immunology

(2009) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice

(2009) M. Schilling et al.   NEUROSCIENCE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Monocyte migration to inflamed skin and lymph nodes is differentially controlled by L-selectin and PSGL-1

(2008) B. Leon et al.   BLOOD

Cell adhesion molecules and ischemic stroke

(2008) Gokhan Yilmaz et al.   NEUROLOGICAL RESEARCH

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase

(2008) M. O. Breckwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA