Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

Indirubin modulates CD4+ T-cell homeostasis via PD1/PTEN/AKT signalling pathway in immune thrombocytopenia

(2019) Yajing Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

NLRP3 inflammasome contributes to neurovascular unit damage in stroke

(2019) Jing Sun et al.   JOURNAL OF DRUG TARGETING

Conjugated Linoleic Acid Ameliorates High fructose‐induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway

(2019) Jianyang Tan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

(2019) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

Interleukin-1 receptor associated kinase (IRAK)-M -mediated type 2 microglia polarization ameliorates the severity of experimental autoimmune encephalomyelitis (EAE)

(2019) Baozhu Liu et al.   JOURNAL OF AUTOIMMUNITY

Epigallocatechin‐3‐Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4/NF‐κB Pathway

(2019) Xin Zhong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Treatment targets for M2 microglia polarization in ischemic stroke

(2018) Ji wang et al.   BIOMEDICINE & PHARMACOTHERAPY

RIPK3/MLKL-Mediated Neuronal Necroptosis Modulates the M1/M2 Polarization of Microglia/Macrophages in the Ischemic Cortex

(2018) Jiping Yang et al.   CEREBRAL CORTEX

Corrigendum to “Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke” [Free Radic. Biol. Med. 104 (2017) 333–345]

(2018) Yuan-Yuan Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures

(2018) Joanna Ślusarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage

(2018) Xiuli Yang et al.   EXPERIMENTAL NEUROLOGY

Post-stroke DHA Treatment Protects Against Acute Ischemic Brain Injury by Skewing Macrophage Polarity Toward the M2 Phenotype

(2018) Wei Cai et al.   Translational Stroke Research

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

(2018) Chongyang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

(2018) Yingzhu Chen et al.   Frontiers in Cellular Neuroscience

Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors

(2018) Cheng-Shyuan Rau et al.   Nutrients

CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma

(2018) Francesca Lepore et al.   Frontiers in Immunology

Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α

(2017) Creed M. Stary et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ARTEMIDA Trial (A Randomized Trial of Efficacy, 12 Months International Double-Blind Actovegin)

(2017) Alla Guekht et al.   STROKE

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

(2017) Jing Ji et al.   Frontiers in Cellular Neuroscience

Indirubin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice through the inhibition of inflammation and the induction of Foxp3-expressing regulatory T cells

(2016) Wenyan Gao et al.   ACTA HISTOCHEMICA

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

(2016) Gerardus P.J. van Hout et al.   EUROPEAN HEART JOURNAL

Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia

(2016) Somayyeh Hamzei Taj et al.   Journal of Neuroimmune Pharmacology

Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms

(2016) Xiaoxing Xiong et al.   Journal of Neuroinflammation

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

(2016) Xinlai Cheng et al.   Molecular Oncology

Meisoindigo, but not its core chemical structure indirubin, inhibits zebrafish interstitial leukocyte chemotactic migration

(2016) Baixin Ye et al.   PHARMACEUTICAL BIOLOGY

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway

(2016) Haroon Badshah et al.   Scientific Reports

Indirubin derivatives: a patent review (2010 – present)

(2015) Nicolas Gaboriaud-Kolar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

TAK-242, an Antagonist for Toll-like Receptor 4, Protects against Acute Cerebral Ischemia/Reperfusion Injury in Mice

(2015) Fang Hua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Engagement of the Aryl Hydrocarbon Receptor inMycobacterium tuberculosis–Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling

(2015) Babak Memari et al.   JOURNAL OF IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

IL-4 Is Required for Sex Differences in Vulnerability to Focal Ischemia in Mice

(2015) Xiaoxing Xiong et al.   STROKE

Microglia/Macrophage Polarization After Experimental Intracerebral Hemorrhage

(2015) Hao Zhao et al.   Translational Stroke Research

Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins

(2015) Nataša Kopitar-Jerala   Frontiers in Molecular Neuroscience

The Antitumor Activity of Meisoindigo against Human Colorectal Cancer HT-29 CellsIn VitroandIn Vivo

(2014) Zuo Mingxin et al.   JOURNAL OF CHEMOTHERAPY

Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress

(2014) Iciar Gárate et al.   Journal of Neuroinflammation

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

(2014) Xiaoxing Xiong et al.   NEUROBIOLOGY OF DISEASE

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

(2013) Sylvie Girard et al.   GLIA

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil

(2013) Chunyun Liu et al.   PLoS One

GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

(2012) Bijay Parajuli et al.   Journal of Neuroinflammation

Distinctive Effects of T Cell Subsets in Neuronal Injury Induced by Cocultured Splenocytes In Vitro and by In Vivo Stroke in Mice

(2012) Lijuan Gu et al.   STROKE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo

(2011) Yi-Bing Ouyang et al.   NEUROBIOLOGY OF DISEASE

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

The Inflammasomes

(2010) Kate Schroder et al.   CELL

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-Like Receptor Tolerance as a Mechanism for Neuroprotection

(2010) Keri B. Vartanian et al.   Translational Stroke Research

Toll-Like Receptor 4-Mediated Myeloid Differentiation Factor 88-Dependent Signaling Pathway Is Activated by Cerebral Ischemia-Reperfusion in Hippocampal CA1 Region in Mice

(2009) Yin Gao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Postischemic Brain Injury Is Attenuated in Mice Lacking the β2-Adrenergic Receptor

(2008) Ru-Quan Han et al.   ANESTHESIA AND ANALGESIA

Stroke

(2008) Geoffrey A Donnan et al.   LANCET