NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice

(2016) F. Denorme et al.   BLOOD

Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats

(2016) Chenhui Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice

(2016) Zhao-Ma Shu et al.   CNS Neuroscience & Therapeutics

Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agent

(2016) Wei Yin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices

(2016) Boris Mlinar et al.   Frontiers in Cellular Neuroscience

Clematichinenoside Serves as a Neuroprotective Agent Against Ischemic Stroke: The Synergistic Action of ERK1/2 and cPKC Pathways

(2016) Chao Liu et al.   Frontiers in Cellular Neuroscience

C1q/Tumor Necrosis Factor-Related Protein-3 Attenuates Brain Injury after Intracerebral Hemorrhage via AMPK-Dependent Pathway in Rat

(2016) Shaohua Wang et al.   Frontiers in Cellular Neuroscience

Blockade of Apoptosis Signal-Regulating Kinase 1 Attenuates Matrix Metalloproteinase 9 Activity in Brain Endothelial Cells and the Subsequent Apoptosis in Neurons after Ischemic Injury

(2016) So Y. Cheon et al.   Frontiers in Cellular Neuroscience

Enantiomers of 3-pentylbenzo[c]thiophen-1(3H)-one: preparation and evaluation of anti-ischemic stroke activities

(2016) Yanlin Jian et al.   RSC Advances

Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells

(2015) Dunjing Wang et al.   INFLAMMATION

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer’s Disease-Like Pathology, Blood–Brain Barrier Disruption, and Synaptic Disorder

(2015) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome

(2015) Anwen Shao et al.   MOLECULAR NEUROBIOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Hydrogen Sulfide Ameliorates Early Brain Injury Following Subarachnoid Hemorrhage in Rats

(2015) Yonghua Cui et al.   MOLECULAR NEUROBIOLOGY

Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice

(2015) Pinghui Jie et al.   Frontiers in Cellular Neuroscience

Mo1164 The Duel Nitric Oxide and Hydrogen Sulfide-Releasing Nonsteroidal Anti-Inflammatory Drugs NOSH-Aspirin, NOSH-Naproxen, and NOSH-Sulindac Are Safe to the Stomach and Have Strong Anti-Inflammatory, Analgesic, Antipyretic, Anti-Platelet, and Anti-Cancer Properties

(2015) Kamran V. Nia et al.   GASTROENTEROLOGY

Role of Hydrogen Sulfide in Early Blood-Brain Barrier Disruption following Transient Focal Cerebral Ischemia

(2015) Zheng Jiang et al.   PLoS One

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia

(2014) Yali Wang et al.   JOURNAL OF NEUROCHEMISTRY

Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents

(2014) Xiaoli Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

(2013) Sylvie Girard et al.   GLIA

NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders

(2013) Moonhee Lee et al.   GLIA

Synthesis and biological activity of NOSH-naproxen (AVT-219) and NOSH-sulindac (AVT-18A) as potent anti-inflammatory agents with chemotherapeutic potential

(2013) Ravinder Kodela et al.   MedChemComm

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease

(2013) Ayman ElAli et al.   Frontiers in Physiology

Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats

(2012) Jun Yin et al.   BRAIN RESEARCH

Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

(2012) Danica B Stanimirovic et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Targeting gaseous molecules to protect against cerebral ischaemic injury: Mechanisms and prospects

(2011) Jun Zhou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats

(2010) Pei Zhuang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia

(2009) Noriko Sumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Signaling by Gasotransmitters

(2009) A. K. Mustafa et al.   Science Signaling

Dysfunctional Cell-Cell Signaling in the Neurovascular Unit as a Paradigm for Central Nervous System Disease

(2008) S. Guo et al.   STROKE

Stroke and the female brain

(2008) Cheryl D Bushnell   Nature clinical practice. Neurology