Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats

Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway

(2020) Li Sun et al.   Frontiers in Pharmacology

Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway

(2020) Li Sun et al.   Cell Death Discovery

Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway

(2020) Guang-xiao Ni et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling

(2019) Junrong Zhu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy

(2019) Yi Zhang et al.   MOLECULES

Astragaloside IV Protects Primary Cerebral Cortical Neurons from Oxygen and Glucose Deprivation/Reoxygenation by Activating the PKA/CREB Pathway

(2019) Bingjie Xue et al.   NEUROSCIENCE

Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway

(2019) Songyi Cheng et al.   LIFE SCIENCES

Adjuvant therapy with Astragalus membranaceus for post-stroke fatigue: a systematic review

(2019) Li Xu et al.   METABOLIC BRAIN DISEASE

Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury

(2019) Jialiang Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Treatment targets for M2 microglia polarization in ischemic stroke

(2018) Ji wang et al.   BIOMEDICINE & PHARMACOTHERAPY

XQ-1H protects against ischemic stroke by regulating microglia polarization through PPARγ pathway in mice

(2018) Rui Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma–Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice

(2018) Liang Wen et al.   JOURNAL OF NEUROTRAUMA

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury

(2018) Junchi He et al.   NEUROBIOLOGY OF DISEASE

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

(2018) Wei Cai et al.   PROGRESS IN NEUROBIOLOGY

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2018) William J. Powers et al.   STROKE

Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II

(2018) Ying Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Minocycline plus N-acteylcysteine induces remyelination, synergistically protects oligodendrocytes, and modifies neuroinflammation in a rat model of mild traumatic brain injury

(2017) Margalit Haber et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms

(2017) Hui-Lin Wang et al.   Oxidative Medicine and Cellular Longevity

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway

(2017) Jichao Yuan et al.   Oncotarget

Patterns of Stroke Between University Hospitals and Nonuniversity Hospitals in Mainland China: Prospective Multicenter Hospital-Based Registry Study

(2017) Deren Wang et al.   World Neurosurgery

Treatment with the PPARγ Agonist Pioglitazone in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem Cells in Rats

(2017) Tomoya Kinouchi et al.   Translational Stroke Research

Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders

(2016) Mithilesh Kumar Jha et al.   BIOCHEMICAL PHARMACOLOGY

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Astragaloside IV, a Natural PPARγ Agonist, Reduces Aβ Production in Alzheimer’s Disease Through Inhibition of BACE1

(2016) Xu Wang et al.   MOLECULAR NEUROBIOLOGY

Delayed Treatment with Green Tea Polyphenol EGCG Promotes Neurogenesis After Ischemic Stroke in Adult Mice

(2016) Jian-Cheng Zhang et al.   MOLECULAR NEUROBIOLOGY

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

(2015) Yuriy Pomeshchik et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia

(2015) Lijuan Han et al.   STROKE

Promoting brain remodeling to aid in stroke recovery

(2015) Zheng Gang Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation