Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia

The Association of Suppressed Hypoxia-Inducible Factor-1 Transactivation of Angiogenesis With Defective Recovery From Cerebral Ischemic Injury in Aged Rats

(2021) Yingjia Guo et al.   Frontiers in Aging Neuroscience

Hypoxia Inducible Factor-1α Attenuates Ischemic Brain Damage by Modulating Inflammatory Response and Glial Activity

(2021) Nashwa Amin et al.   Cells

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model

(2020) Ayesha Singh et al.   Scientific Reports

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis

(2019) Iman H. El Khashab et al.   BIOMEDICINE & PHARMACOTHERAPY

Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke

(2019) Haomeng Zhu et al.   Journal of Neurosurgical Sciences

Neuroprotection of cordycepin in NMDA-induced excitotoxicity by modulating adenosine A1 receptors

(2019) Zhong-Si-Wei Dong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke

(2019) Xiaoxi Pei et al.   EXPERIMENTAL CELL RESEARCH

S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke

(2019) Mushfiquddin Khan et al.   Journal of Stroke & Cerebrovascular Diseases

GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1α

(2018) Mushfiquddin Khan et al.   BEHAVIOURAL BRAIN RESEARCH

Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia

(2018) Juan G. Zarruk et al.   EXPERIMENTAL NEUROLOGY

Effectiveness of arginase inhibitors against experimentally induced stroke

(2018) Waleed Barakat et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Mohsen Naghavi et al.   LANCET

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury

(2017) Mushfiquddin Khan et al.   Neural Regeneration Research

YAMATO Study (Tissue-Type Plasminogen Activator and Edaravone Combination Therapy)

(2017) Junya Aoki et al.   STROKE

Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice

(2017) Seoyeon Bok et al.   Oncotarget

Mechanical stress activates NMDA receptors in the absence of agonists

(2017) Mohammad Mehdi Maneshi et al.   Scientific Reports

Chronic cocaine induces HIF-VEGF pathway activation along with angiogenesis in the brain

(2017) Wei Yin et al.   PLoS One

The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits

(2017) Jin Zhou et al.   PLoS One

N -Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway

(2016) Ping Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition on the S -nitrosylation of MKK4 can protect hippocampal CA1 neurons in rat cerebral ischemia/reperfusion

(2016) Xue Wen Wei et al.   BRAIN RESEARCH BULLETIN

Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids

(2016) Angela Maria Amorini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke

(2016) Philipp Barteczek et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke

(2016) Ziyan Zhang et al.   NEUROBIOLOGY OF DISEASE

Combination of Thrombolysis and Statins in Acute Stroke Is Safe

(2016) Joan Montaner et al.   STROKE

Effects and Mechanism of Action of Inducible Nitric Oxide Synthase on Apoptosis in a Rat Model of Cerebral Ischemia-Reperfusion Injury

(2015) Li Zheng et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Dual Labeling Biotin Switch Assay to Reduce Bias Derived From Different Cysteine SubpopulationsNovelty and Significance

(2015) Heaseung Sophia Chung et al.   CIRCULATION RESEARCH

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

(2015) P.S. Garry et al.   EXPERIMENTAL NEUROLOGY

l-NAME combats excitotoxicity and recuperates neurological deficits in MCAO/R rats

(2015) B. Pramila et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chrysin Protects against Focal Cerebral Ischemia/Reperfusion Injury in Mice through Attenuation of Oxidative Stress and Inflammation

(2014) Yang Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inducible Nitric Oxide Synthase in Neutrophils and Endothelium Contributes to Ischemic Brain Injury in Mice

(2014) Lidia Garcia-Bonilla et al.   JOURNAL OF IMMUNOLOGY

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

(2014) Ruoli L. Chen et al.   JOURNAL OF NEUROCHEMISTRY

Recombinant Human Erythropoietin Augments Angiogenic Responses in a Neonatal Rat Model of Cerebral Unilateral Hypoxia-Ischemia

(2014) Lihua Zhu et al.   Neonatology

Hypoxia-inducible factor-1α upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction

(2014) Tao Huang et al.   NEUROREPORT

Role of Nitric Oxide Synthases in Early Blood-Brain Barrier Disruption following Transient Focal Cerebral Ischemia

(2014) Zheng Jiang et al.   PLoS One

Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

(2014) Stefan Reischl et al.   PLoS One

The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

(2013) Kiyoshi Kikuchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotection of S-nitrosoglutathione against ischemic injury by down-regulating Fas S-nitrosylation and downstream signaling

(2013) X.-H. Yin et al.   NEUROSCIENCE

Cerebral ischemia-reperfusion induces GAPDH S-nitrosylation and nuclear translocation

(2012) Chong Li et al.   BIOCHEMISTRY-MOSCOW

Induction of inducible nitric oxide synthase by isoflurane post-conditioning via hypoxia inducible factor-1α during tolerance against ischemic neuronal injury

(2012) Qi Fang Li et al.   BRAIN RESEARCH

Asymmetric Dimethyarginine as Marker and Mediator in Ischemic Stroke

(2012) Shufen Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effects of mGluR5 Positive Modulators Against Traumatic Neuronal Injury Through PKC-Dependent Activation of MEK/ERK Pathway

(2012) Tao Chen et al.   NEUROCHEMICAL RESEARCH

N-Methyl-D-Aspartate Receptor-Dependent Denitrosylation of Neuronal Nitric Oxide Synthase Increase the Enzyme Activity

(2012) Zhong-Wei Qu et al.   PLoS One

Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

(2012) Reiner Kunze et al.   STROKE

Mutant Erythropoietin Without Erythropoietic Activity Is Neuroprotective Against Ischemic Brain Injury

(2012) Yu Gan et al.   STROKE

S-Nitrosylation signaling regulates cellular protein interactions

(2011) Nadzeya V. Marozkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

S-nitrosylation in the regulation of gene transcription

(2011) Yonggang Sha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia

(2011) Pirusha Ketheeswaranathan et al.   BRAIN RESEARCH

Current Therapeutic Strategies to Mitigate the eNOS Dysfunction in Ischaemic Stroke

(2011) Kirtiman Srivastava et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

N-Methyl-d-aspartate Receptor Mechanosensitivity Is Governed by C Terminus of NR2B Subunit

(2011) Pallab Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prophylactic neuroprotection against stroke: Low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function

(2011) Yanxin Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients — A preliminary study

(2011) Kazumi Kimura et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

(S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death

(2011) Qian Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

Andrographolide Inhibits PI3K/AKT-Dependent NOX2 and iNOS Expression Protecting Mice against Hypoxia/Ischemia-Induced Oxidative Brain Injury

(2011) Chang-Ming Chern et al.   PLANTA MEDICA

Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke

(2011) Jingqi Yan et al.   PLoS One

Endothelial Nitric Oxide Synthase Mediates Endogenous Protection Against Subarachnoid Hemorrhage-Induced Cerebral Vasospasm

(2011) Ananth K. Vellimana et al.   STROKE

Advances in stroke therapy

(2011) Hayder Jaffer et al.   Drug Delivery and Translational Research

The diverse functions of GAPDH: Views from different subcellular compartments

(2010) Carlos Tristan et al.   CELLULAR SIGNALLING

ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats

(2010) Pei Zhuang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Nitric Oxide Production during Cerebral Ischemia and Reperfusion in eNOS- and nNOS-Knockout Mice

(2010) Yasuo Ito et al.   CURRENT NEUROVASCULAR RESEARCH

Neuroprotection by Dimethyloxalylglycine following Permanent and Transient Focal Cerebral Ischemia in Rats

(2010) Simon Nagel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotective actions of aminoguanidine involve reduced the activation of calpain and caspase-3 in a rat model of stroke

(2010) Ming Sun et al.   NEUROCHEMISTRY INTERNATIONAL

Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation

(2010) P.-T. Doulias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caffeinol at the Receptor Level

(2010) Xiurong Zhao et al.   STROKE

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

(2009) Sarah K. Harten et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia Inducible Factor 1 as a Therapeutic Target in Ischemic Stroke

(2009) Honglian Shi   CURRENT MEDICINAL CHEMISTRY

Role of endothelial nitric oxide synthetase in arteriogenesis after stroke in mice

(2009) X. Cui et al.   NEUROSCIENCE

Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications

(2009) Li Zhou et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia

(2008) Roderic H. Fabian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hypoxia Inducible Factor-1 Improves the Actions of Nitric Oxide and Natriuretic Peptides after Simulated Ischemia-Reperfusion

(2008) Jason A. Luciano et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

(2008) F. Léveillé et al.   FASEB JOURNAL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic–ischemic model

(2008) Wanqiu Chen et al.   NEUROBIOLOGY OF DISEASE

Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood–brain barrier dysfunction in stroke

(2007) M. Guo et al.   NEUROSCIENCE