The novel Nrf2 activator CDDO‐EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice

CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke

(2019) Joel Faustino et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway

(2019) Sisi Liu et al.   NEUROSCIENCE LETTERS

Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain

(2019) Wenting Zhang et al.   CNS Neuroscience & Therapeutics

Sexually dimorphic microglia and ischemic stroke

(2019) Nadine Kerr et al.   CNS Neuroscience & Therapeutics

Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease

(2019) Meng‐yan Hu et al.   CNS Neuroscience & Therapeutics

Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2/HO-1 signaling pathway in cultured astrocytes

(2019) Ying Wang et al.   NEUROSCIENCE LETTERS

Achyranthes bidentata polypeptide k suppresses neuroinflammation in BV2 microglia through Nrf2-dependent mechanism

(2019) Qiong Cheng et al.   Annals of Translational Medicine

Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2

(2019) Tuo Yang et al.   EXPERIMENTAL NEUROLOGY

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model

(2018) Zongyong Zhang et al.   EXPERIMENTAL NEUROLOGY

Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway

(2018) Leilei Mao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling

(2018) Lixun Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of microRNA-126 in vascular cognitive impairment in mice

(2018) Peng Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury

(2018) Jingyan Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways

(2017) Entaz Bahar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2/HO-1 pathway

(2017) Cun-Xin Zhang et al.   Spine Journal

The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy

(2017) Dongwei Xu et al.   Cell Death & Disease

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice

(2016) Keita Yamauchi et al.   NEUROSCIENCE

The High Cost of Stroke and Stroke Cytoprotection Research

(2016) Paul A. Lapchak et al.   Translational Stroke Research

Inflammatory Responses in Brain Ischemia

(2015) Masahito Kawabori et al.   CURRENT MEDICINAL CHEMISTRY

Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms

(2015) Uchechukwu P. Okorji et al.   MOLECULAR NEUROBIOLOGY

Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke

(2015) Candice M. Brown et al.   Translational Stroke Research

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Molecular dialogs between the ischemic brain and the peripheral immune system: Dualistic roles in injury and repair

(2014) Chengrui An et al.   PROGRESS IN NEUROBIOLOGY

Hyperglycemia, Acute Ischemic Stroke, and Thrombolytic Therapy

(2014) Sherif Hafez et al.   Translational Stroke Research

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

The Nrf2 pathway as a potential therapeutic target for Huntington disease

(2010) Carole Escartin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE