Structural analysis of the basal state of the Artemis:DNA-PKcs complex

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

(2022) Shikang Liang et al.   NATURE

Physical ARTEMIS:DNA-PKcs interaction is necessary for V(D)J recombination

(2022) Doris Niewolik et al.   NUCLEIC ACIDS RESEARCH

Structure of an activated DNA-PK and its implications for NHEJ

(2021) Xuemin Chen et al.   MOLECULAR CELL

Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway

(2021) Benjamin M. Stinson et al.   Annual Review of Biochemistry

CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks

(2021) Ellen D. Zhong et al.   NATURE METHODS

Structural basis of long-range to short-range synaptic transition in NHEJ

(2021) Siyu Chen et al.   NATURE

Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment

(2021) D. Lucas Kerr et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM

(2021) Ali Punjani et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

(2021) Amanda K. Chaplin et al.   MOLECULAR CELL

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

(2021) Yuliana Yosaatmadja et al.   NUCLEIC ACIDS RESEARCH

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

Nonhomologous DNA end joining of nucleosomal substrates in a purified system

(2021) Christina A. Gerodimos et al.   DNA REPAIR

Developing a Peptide That Inhibits DNA Repair by Blocking the Binding of Artemis and DNA Ligase IV to Enhance Tumor Radiosensitivity

(2021) Chu Zhu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Evolution of drug delivery systems: From 1950 to 2020 and beyond

(2021) Haesun Park et al.   JOURNAL OF CONTROLLED RELEASE

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

(2021) Lan Liu et al.   MOLECULAR CELL

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination

(2020) Z. Anne Esguerra et al.   MOLECULAR IMMUNOLOGY

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features

(2020) Md Fazlul Karim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation

(2020) Katheryn Meek   NUCLEIC ACIDS RESEARCH

Improvement of cryo-EM maps by density modification

(2020) Thomas C. Terwilliger et al.   NATURE METHODS

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

(2020) James P. Lees-Miller et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Density modification of cryo-EM maps

(2020) Thomas C. Terwilliger et al.   Acta Crystallographica Section D-Structural Biology

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

(2020) Ali Punjani et al.   NATURE METHODS

Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM

(2020) Shikang Liang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs

(2020) Marijke Jansma et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A Comprehensive Review on Current Advances in Peptide Drug Development and Design

(2019) Andy Chi-Lung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

(2018) Takanori Nakane et al.   eLife

Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity

(2017) Christina A. Gerodimos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibition of the Nuclease ARTEMIS Is Mediated by a Physical Interaction between Its Catalytic and C-terminal Domains

(2017) Doris Niewolik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM structure of the DNA-PK holoenzyme

(2017) Humayun Sharif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

(2017) Davide Normanno et al.   eLife

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

(2016) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment

(2016) Agnel Praveen Joseph et al.   METHODS

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex

(2016) Howard H.Y. Chang et al.   NUCLEIC ACIDS RESEARCH

Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency

(2015) Kerstin Felgentreff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity

(2014) Sicong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation

(2014) J. A. Neal et al.   MOLECULAR AND CELLULAR BIOLOGY

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

(2014) Elli Papaemmanuil et al.   NATURE GENETICS

Structure of the Catalytic Region of DNA Ligase IV in Complex with an Artemis Fragment Sheds Light on Double-Strand Break Repair

(2013) Takashi Ochi et al.   STRUCTURE

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

(2012) Shruti Malu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining

(2012) Pablo De Ioannes et al.   Cell Reports

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

(2011) Edward P. Morris et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The multifunctionalSNM1gene family: not just nucleases

(2010) Yiyi Yan et al.   Future Oncology

Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions

(2010) Grigore D. Pintilie et al.   JOURNAL OF STRUCTURAL BIOLOGY

Nucleases: diversity of structure, function and mechanism

(2010) Wei Yang   QUARTERLY REVIEWS OF BIOPHYSICS

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination

(2008) Haihui Lu et al.   MOLECULAR CELL

Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding

(2008) Dewight R. Williams et al.   STRUCTURE

Protein Structure Fitting and Refinement Guided by Cryo-EM Density

(2008) Maya Topf et al.   STRUCTURE