Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs

Structures and regulations of ATM and ATR, master kinases in genome integrity

(2020) Rhys M Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

(2020) Lukas M Langer et al.   eLife

Defining a new nomenclature for the structures of active and inactive kinases

(2019) Vivek Modi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of allosteric regulation of Tel1/ATM kinase

(2019) Jiyu Xin et al.   CELL RESEARCH

Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA, but no DNA ends

(2019) Sarem Hailemariam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into the activation of ATM kinase

(2019) Jianxiong Xiao et al.   CELL RESEARCH

Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

(2019) Marijke Jansma et al.   STRUCTURE

Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations

(2019) Luke A. Yates et al.   STRUCTURE

InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1–SMG8–SMG9 complex

(2019) Yair Gat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Architecture and activation of phosphatidylinositol 3-kinase related kinases

(2018) Stefan Imseng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

(2017) Ishan Deshpande et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

Cryo-EM structure of the DNA-PK holoenzyme

(2017) Humayun Sharif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP

(2017) Xuejuan Wang et al.   SCIENCE

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Structures of closed and open conformations of dimeric human ATM

(2017) Domagoj Baretić et al.   Science Advances

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

(2014) Catherine Chen et al.   MOLECULAR CELL

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

(2013) Frederick W. Alt et al.   CELL

PRKDC mutations in a SCID patient with profound neurological abnormalities

(2013) Lisa Woodbine et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative Proteomics Reveal ATM Kinase-dependent Exchange in DNA Damage Response Complexes

(2012) Serah Choi et al.   JOURNAL OF PROTEOME RESEARCH

ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

(2011) Shizhou Liu et al.   MOLECULAR CELL

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

(2011) Zhao Qin Bao et al.   STRUCTURE

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

(2008) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY