Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Mitigating local over-fitting during single particle reconstruction with SIDESPLITTER

(2020) Kailash Ramlaul et al.   JOURNAL OF STRUCTURAL BIOLOGY

Topaz-Denoise: general deep denoising models for cryoEM and cryoET

(2020) Tristan Bepler et al.   Nature Communications

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

(2019) Hui Xu et al.   CELL

Conformation space of a heterodimeric ABC exporter under turnover conditions

(2019) Susanne Hofmann et al.   NATURE

Structure of the Respiratory Syncytial Virus Polymerase Complex

(2019) Morgan S.A. Gilman et al.   CELL

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

(2019) Jonathan Kim et al.   NATURE

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

(2019) Anthony H. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the docking of mTORC1 on the lysosomal surface

(2019) Kacper B. Rogala et al.   SCIENCE

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps

(2018) Jose Luis Vilas et al.   STRUCTURE

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Membrane protein structural biology in the era of single particle cryo-EM

(2018) Yifan Cheng   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Local Agreement Filtering Algorithm for Transmission EM Reconstructions

(2018) Kailash Ramlaul et al.   JOURNAL OF STRUCTURAL BIOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

High resolution single particle refinement in EMAN2.1

(2016) James M. Bell et al.   METHODS

Structure of the STRA6 receptor for retinol uptake

(2016) Y. Chen et al.   SCIENCE

Single-Particle Cryo-EM at Crystallographic Resolution

(2015) Yifan Cheng   CELL

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

ResLog plots as an empirical metric of the quality of cryo-EM reconstructions

(2014) Scott M. Stagg et al.   JOURNAL OF STRUCTURAL BIOLOGY

One number does not fit all: Mapping local variations in resolution in cryo-EM reconstructions

(2013) Giovanni Cardone et al.   JOURNAL OF STRUCTURAL BIOLOGY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

A Bayesian adaptive basis algorithm for single particle reconstruction

(2012) Alp Kucukelbir et al.   JOURNAL OF STRUCTURAL BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY