Nucleases: diversity of structure, function and mechanism

Substrate recognition and catalysis by flap endonucleases and related enzymes

(2010) Christopher G. Tomlinson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae

(2010) Miguel G. Blanco et al.   DNA REPAIR

Complete Khoisan and Bantu genomes from southern Africa

(2010) Stephan C. Schuster et al.   NATURE

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site

(2010) Giedrius Sasnauskas et al.   NUCLEIC ACIDS RESEARCH

The C-terminal domain is sufficient for endonuclease activity ofNeisseria gonorrhoeaeMutL

(2009) Viswanadham Duppatla et al.   BIOCHEMICAL JOURNAL

Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation

(2009) Melissa J. Moore et al.   CELL

Molecular Architecture of the Mos1 Paired-End Complex: The Structural Basis of DNA Transposition in a Eukaryote

(2009) Julia M. Richardson et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

Structural insights into RNA splicing

(2009) Navtej Toor et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural and functional modules in RNA interference

(2009) Marcin Nowotny et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DNA end resection: Many nucleases make light work

(2009) Eleni P. Mimitou et al.   DNA REPAIR

Retroviral integrase superfamily: the structural perspective

(2009) Marcin Nowotny   EMBO REPORTS

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription

(2009) James J. Champoux et al.   FEBS Journal

Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes

(2009) Takashi Tadokoro et al.   FEBS Journal

AdnAB: a new DSB-resecting motor-nuclease from mycobacteria

(2009) K. M. Sinha et al.   GENES & DEVELOPMENT

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

Characterization of the Mycobacterial AdnAB DNA Motor Provides Insights into the Evolution of Bacterial Motor-Nuclease Machines

(2009) Mihaela-Carmen Unciuleac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origins and activities of the eukaryotic exosome

(2009) S. Lykke-Andersen et al.   JOURNAL OF CELL SCIENCE

On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family

(2009) Vera Pingoud et al.   JOURNAL OF MOLECULAR BIOLOGY

Deciphering the Distinct Role for the Metal Coordination Motif in the Catalytic Activity of Mycobacterium smegmatis Topoisomerase I

(2009) Anuradha Gopal Bhat et al.   JOURNAL OF MOLECULAR BIOLOGY

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

(2009) Yanli Wang et al.   NATURE

Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1

(2009) Song Xiang et al.   NATURE

Bacteriophage T4 endonuclease II, a promiscuous GIY-YIG nuclease, binds as a tetramer to two DNA substrates

(2009) Pernilla Lagerbäck et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the ββα-Me type II restriction endonuclease Hpy99I with target DNA

(2009) Monika Sokolowska et al.   NUCLEIC ACIDS RESEARCH

The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

(2009) Claudia Schneider et al.   NUCLEIC ACIDS RESEARCH

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family

(2009) V. M. Castillo-Acosta et al.   NUCLEIC ACIDS RESEARCH

REBASE—a database for DNA restriction and modification: enzymes, genes and genomes

(2009) Richard J. Roberts et al.   NUCLEIC ACIDS RESEARCH

The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site

(2009) K. R. Andersen et al.   RNA

Crystal Structure of E. coli RecE Protein Reveals a Toroidal Tetramer for Processing Double-Stranded DNA Breaks

(2009) Jinjin Zhang et al.   STRUCTURE

Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense

(2009) Blake Wiedenheft et al.   STRUCTURE

The ribozyme core of group II introns: a structure in want of partners

(2009) François Michel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Catalytic Strategies of Self-Cleaving Ribozymes

(2008) Jesse C. Cochrane et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

DNase 1 and systemic lupus erythematosus

(2008) Fernando Martínez Valle et al.   AUTOIMMUNITY REVIEWS

Probing the Catalytic Triad of an Archaeal RNA Splicing Endonuclease†

(2008) Kate Calvin et al.   BIOCHEMISTRY

Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection

(2008) Orsolya Barabas et al.   CELL

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

RNA-splicing endonuclease structure and function

(2008) K. Calvin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity

(2008) Thomas Rutkoski et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members

(2008) T. A. Farazi et al.   DEVELOPMENT

Unique and overlapping functions of the Exo1, Mre11 and Pso2 nucleases in DNA repair

(2008) Alicia F. Lam et al.   DNA REPAIR

Structure and function of an RNase H domain at the heart of the spliceosome

(2008) Vladimir Pena et al.   EMBO JOURNAL

Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD

(2008) Marcin Nowotny et al.   EMBO JOURNAL

Aicardi–Goutières syndrome (AGS)

(2008) John B.P. Stephenson   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae

(2008) Laila Niiranen et al.   FEBS Journal

Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

(2008) J. Carte et al.   GENES & DEVELOPMENT

Crystal structure of the Mus81-Eme1 complex

(2008) J. H. Chang et al.   GENES & DEVELOPMENT

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

(2008) Meltem Muftuoglu et al.   HUMAN GENETICS

The Tumor Marker Human Placental Protein 11 Is an Endoribonuclease

(2008) Pietro Laneve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical and Traditional Mutagenesis of Vaccinia DNA Topoisomerase Provides Insights to Cleavage Site Recognition and Transesterification Chemistry

(2008) Lyudmila Yakovleva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three Metal Ions Participate in the Reaction Catalyzed by T5 Flap Endonuclease

(2008) Karl Syson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bound Nucleotide Controls the Endonuclease Activity of Mismatch Repair Enzyme MutL

(2008) Kenji Fukui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats

(2008) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PMS2 Subunit of Human MutLα Contains a Metal Ion Binding Domain of the Iron-Dependent Repressor Protein Family

(2008) Jan Kosinski et al.   JOURNAL OF MOLECULAR BIOLOGY

Comparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal Ion

(2008) Jesse G. Zalatan et al.   JOURNAL OF MOLECULAR BIOLOGY

RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks

(2008) M. S. Dillingham et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Crystal Structure of CRN-4: Implications for Domain Function in Apoptotic DNA Degradation

(2008) Y.-Y. Hsiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Studies of the 5' Exonuclease and Endonuclease Activities of CPSF-73 in Histone Pre-mRNA Processing

(2008) X.-c. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

RNA Repair: An Antidote to Cytotoxic Eukaryal RNA Damage

(2008) Jayakrishnan Nandakumar et al.   MOLECULAR CELL

Structure of the Active Subunit of the Yeast Exosome Core, Rrp44: Diverse Modes of Substrate Recruitment in the RNase II Nuclease Family

(2008) Esben Lorentzen et al.   MOLECULAR CELL

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

(2008) Yanli Wang et al.   NATURE

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

Structural basis for exon recognition by a group II intron

(2008) Navtej Toor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

(2008) Dustin B Ritchie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An equivalent metal ion in one- and two-metal-ion catalysis

(2008) Wei Yang   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA apurinic-apyrimidinic site binding and excision by endonuclease IV

(2008) Elsa D Garcin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the motor subunit of type I restriction-modification complex EcoR124I

(2008) Mikalai Lapkouski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi

(2008) Harrison W Gabel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway

(2008) C. M. Moure et al.   NUCLEIC ACIDS RESEARCH

Structural and evolutionary classification of Type II restriction enzymes based on theoretical and experimental analyses

(2008) Jerzy Orlowski et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the  -finger domain of Prp8 reveals analogy to ribosomal proteins

(2008) K. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structural analysis of protein-protein interactions drastically destabilized by a single mutation

(2008) Yoshiaki Urakubo et al.   PROTEIN SCIENCE

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

(2008) Allyn J. Schoeffler et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme

(2008) C. MacElrevey et al.   RNA

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

(2008) S. J. J. Brouns et al.   SCIENCE

Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis

(2008) Young-In Chi et al.   PLOS BIOLOGY

The Buried Diversity of Bovine Seminal Ribonuclease: Shape and Cytotoxicity of the Swapped Non-covalent Form of the Enzyme

(2007) Antonello Merlino et al.   JOURNAL OF MOLECULAR BIOLOGY

CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea

(2007) Rotem Sorek et al.   NATURE REVIEWS MICROBIOLOGY