Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

Structure of an activated DNA-PK and its implications for NHEJ

(2021) Xuemin Chen et al.   MOLECULAR CELL

Structural basis of long-range to short-range synaptic transition in NHEJ

(2021) Siyu Chen et al.   NATURE

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

(2021) Amanda K. Chaplin et al.   MOLECULAR CELL

ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion

(2020) Demis Menolfi et al.   Cell and Bioscience

Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models

(2020) Frank T. Zenke et al.   MOLECULAR CANCER THERAPEUTICS

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

(2020) Mark T. J. van Bussel et al.   BRITISH JOURNAL OF CANCER

Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM

(2020) Shikang Liang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

DNA-PK as an Emerging Therapeutic Target in Cancer

(2019) Ismail S. Mohiuddin et al.   Frontiers in Oncology

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

(2019) Jacqueline H. L. Fok et al.   Nature Communications

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

(2019) Frederick W. Goldberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models

(2019) Hannah C. Wise et al.   Scientific Reports

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Building Proteins in a Day: Efficient 3D Molecular Structure Estimation with Electron Cryomicroscopy

(2017) Ali Punjani et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM structure of the DNA-PK holoenzyme

(2017) Humayun Sharif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Identifying Interactions that Determine Fragment Binding at Protein Hotspots

(2016) Chris J. Radoux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein

(2016) Monika Bokori-Brown et al.   Nature Communications

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

(2015) Nicholas Jette et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

Doxorubicin, DNA torsion, and chromatin dynamics

(2013) Fan Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The N-terminal Region of the DNA-dependent Protein Kinase Catalytic Subunit Is Required for Its DNA Double-stranded Break-mediated Activation

(2013) Anthony J. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE