Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?

(2020) Rita Moretti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Perivascular spaces in the brain: anatomy, physiology and pathology

(2020) Joanna M. Wardlaw et al.   Nature Reviews Neurology

Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity

(2020) Wanlin Yang et al.   Frontiers in Aging Neuroscience

The metabolic changes in the hippocampus of an atherosclerotic rat model and the regulation of aerobic training

(2020) Beibei Liu et al.   METABOLIC BRAIN DISEASE

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia

(2020) Maiko T. Uemura et al.   Frontiers in Aging Neuroscience

Concomitant enlargement of perivascular spaces and decrease in glymphatic transport in an animal model of cerebral small vessel disease

(2020) Yang Xue et al.   BRAIN RESEARCH BULLETIN

Interpericyte tunnelling nanotubes regulate neurovascular coupling

(2020) Luis Alarcon-Martinez et al.   NATURE

Serum albumin and beta-amyloid deposition in the human brain

(2020) Jee Wook Kim et al.   NEUROLOGY

A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions: Potential Relevance to Cerebral Small Vessel Disease

(2020) Narek Manukjan et al.   Cells

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

(2020) Michael S. Stringer et al.   Translational Stroke Research

Volumetric distribution of perivascular space in relation to mild cognitive impairment

(2020) Farshid Sepehrband et al.   NEUROBIOLOGY OF AGING

Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid

(2019) Susan A Austin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

(2019) Divna Lazic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serum homocysteine level is related to cerebral small vessel disease in a healthy population

(2019) Ki-Woong Nam et al.   NEUROLOGY

Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

(2019) Chao Tan et al.   NEURON

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

(2019) Sau May Wong et al.   NEUROLOGY

Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients

(2019) Saima Hilal et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer’s Disease and in Down Syndrome Dementia

(2019) Ruma Raha-Chowdhury et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia

(2019) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis

(2019) Farah Francis et al.   International Journal of Stroke

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

(2019) Michelle Erickson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small vessel disease: mechanisms and clinical implications

(2019) Joanna M Wardlaw et al.   LANCET NEUROLOGY

CNS small vessel disease

(2019) Rocco J. Cannistraro et al.   NEUROLOGY

Neuroimaging studies on cognitive impairment due to cerebral small vessel disease

(2019) Jing Du et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Enlarged basal ganglia perivascular spaces and sleep parameters. A population-based study

(2019) Oscar H. Del Brutto et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

(2019) Kristian Nygaard Mortensen et al.   JOURNAL OF NEUROSCIENCE

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model

(2019) Masahito Nakazaki et al.   NEUROSCIENCE

Chronic Cortical Cerebral Microinfarcts Slow Down Cognitive Recovery After Acute Ischemic Stroke

(2019) Sharmila Sagnier et al.   STROKE

Neuroimaging of Cerebral Small Vessel Disease and Age-Related Cognitive Changes

(2019) Michelle R. Caunca et al.   Frontiers in Aging Neuroscience

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

(2019) Stefano Tarantini et al.   Redox Biology

Inflammation and cerebral small vessel disease: A systematic review

(2019) Audrey Low et al.   AGEING RESEARCH REVIEWS

Genetic Factors of Cerebral Small Vessel Disease and Their Potential Clinical Outcome

(2019) Vo Van Giau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions

(2019) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Changes of white matter integrity and structural network connectivity in nondemented cerebral small‐vessel disease

(2019) Chengxia Liu et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus

(2019) Qin Yang et al.   EBioMedicine

Contributions of Aging to Cerebral Small Vessel Disease

(2019) T. Michael De Silva et al.   Annual Review of Physiology

Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-κB pathway

(2019) Weiwei Qin et al.   Aging-US

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

(2018) Jean-François Ghersi-Egea et al.   ACTA NEUROPATHOLOGICA

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

Endothelium-dependent responses in the microcirculation observed in vivo

(2018) W. I. Rosenblum   Acta Physiologica

Cerebral small vessel disease and the risk of dementia: A systematic review and meta-analysis of population-based evidence

(2018) Daniel Bos et al.   Alzheimers & Dementia

Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline

(2018) Nathalie Thorin-Trescases et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The relationship of cerebral microbleeds to cognition and incident dementia in non-demented older individuals

(2018) Matt Paradise et al.   Brain Imaging and Behavior

Understanding the role of the perivascular space in cerebral small vessel disease

(2018) Rosalind Brown et al.   CARDIOVASCULAR RESEARCH

Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1)

(2018) Andreas Charidimou et al.   International Journal of Stroke

White matter degeneration in vascular and other ageing-related dementias

(2018) Yoshiki Hase et al.   JOURNAL OF NEUROCHEMISTRY

Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment

(2018) Zhi Wang et al.   Journal of Neuroinflammation

Prevalence of hippocampal enlarged perivascular spaces in a sample of patients with hypertension and their relation with vascular risk factors and cognitive function

(2018) Joan Jiménez-Balado et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Effect of Low-Dose Statins and Apolipoprotein E Genotype on Cerebral Small Vessel Disease in Older Hypertensive Patients: A Subgroup Analysis of a Randomized Clinical Trial

(2018) Tiantian Ji et al.   Journal of the American Medical Directors Association

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Cerebral small vessel disease: from a focal to a global perspective

(2018) Annemieke ter Telgte et al.   Nature Reviews Neurology

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Review: Vascular dementia: clinicopathologic and genetic considerations

(2018) H. V. Vinters et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The pathology and pathophysiology of vascular dementia

(2018) Raj N. Kalaria   NEUROPHARMACOLOGY

Role of oligodendrocyte-neurovascular unit in white matter repair

(2018) Gen Hamanaka et al.   NEUROSCIENCE LETTERS

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases

(2018) Bao-Liang Sun et al.   PROGRESS IN NEUROBIOLOGY

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

(2018) Rikesh M. Rajani et al.   Science Translational Medicine

Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load

(2018) Iolanda Riba-Llena et al.   STROKE

Effect of Antihypertensive Medication on Cerebral Small Vessel Disease

(2018) Tessa van Middelaar et al.   STROKE

Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable

(2018) Marie-Gabrielle Duperron et al.   STROKE

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

(2018) Iben Lundgaard et al.   Scientific Reports

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

(2018) Luis Alarcon-Martinez et al.   eLife

Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease

(2018) Iain D. Croall et al.   JAMA Neurology

Emerging Role of Immunity in Cerebral Small Vessel Disease

(2018) Ying Fu et al.   Frontiers in Immunology

Cerebral Small Vessel Disease

(2018) Qian Li et al.   CELL TRANSPLANTATION

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

Enlarged perivascular spaces and cognition

(2018) Saima Hilal et al.   NEUROLOGY

Glibenclamide Enhances the Therapeutic Benefits of Early Hypothermia after Severe Stroke in Rats

(2018) Shuzhen Zhu et al.   Aging and Disease

Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease

(2018) Shuna Yang et al.   Clinical Interventions in Aging

Visceral Obesity Relates to Deep White Matter Hyperintensities via Inflammation

(2018) Leonie Lampe et al.   ANNALS OF NEUROLOGY

Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow

(2018) Yulu Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral small vessel disease: neuroimaging markers and clinical implication

(2018) Xiaodong Chen et al.   JOURNAL OF NEUROLOGY

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Klotho controls the brain–immune system interface in the choroid plexus

(2018) Lei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease

(2018) Marlies P. Noz et al.   STROKE

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury

(2018) Stéphanie Debette et al.   JAMA Neurology

Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions

(2018) Karin M. E. Forsberg et al.   Acta Neuropathologica Communications

Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system

(2017) Huixia Ren et al.   FASEB JOURNAL

Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing

(2017) Michael J Thrippleton et al.   International Journal of Stroke

Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer’s Disease: A Pilot Study

(2017) Willem H. Bouvy et al.   JOURNAL OF ALZHEIMERS DISEASE

Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly

(2017) Leonie Lampe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

(2017) Gargi Banerjee et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Collagenosis of the Deep Medullary Veins: An Underrecognized Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction?

(2017) Julia Keith et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation

(2017) Clotilde Lecrux et al.   JOURNAL OF NEUROSCIENCE

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

(2017) Minghuan Wang et al.   JOURNAL OF NEUROSCIENCE

Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System

(2017) Steffi Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

Periventricular White Matter Hyperintensities and Functional Decline

(2017) Mandip S. Dhamoon et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

Detection, risk factors, and functional consequences of cerebral microinfarcts

(2017) Susanne J van Veluw et al.   LANCET NEUROLOGY

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies

(2017) Poornima Venkat et al.   NEUROBIOLOGY OF AGING

CADASIL accelerated by acute hypotension

(2017) Jacqueline A. Pettersen et al.   NEUROLOGY

Space and location of cerebral microbleeds, cognitive decline, and dementia in the community

(2017) Jie Ding et al.   NEUROLOGY

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Cilostazol Use Is Associated with Reduced Risk of Dementia: A Nationwide Cohort Study

(2017) Shu-Yu Tai et al.   Neurotherapeutics

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders

(2017) Toshiaki Taoka et al.   RADIOGRAPHICS

Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease

(2017) Tae-Jin Song et al.   SLEEP MEDICINE

The Role of Nutrition in the Risk and Burden of Stroke

(2017) Graeme J. Hankey   STROKE

Intravoxel Incoherent Motion Imaging in Small Vessel Disease

(2017) C. Eleana Zhang et al.   STROKE

The relationship between ambulatory blood pressure variability and enlarged perivascular spaces: a cross-sectional study

(2017) Shuna Yang et al.   BMJ Open

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Large Perivascular Spaces Visible on Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia

(2017) Jie Ding et al.   JAMA Neurology

Diffusion tensor image segmentation of the cerebrum provides a single measure of cerebral small vessel disease severity related to cognitive change

(2017) Owen A. Williams et al.   NeuroImage-Clinical

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

(2017) Antje Appelt-Menzel et al.   Stem Cell Reports

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

(2017) Connor A. Emdin et al.   CIRCULATION

Stimulation of adult hippocampal neurogenesis by physical exercise and enriched environment is disturbed in a CADASIL mouse model

(2017) C. Klein et al.   Scientific Reports

Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid

(2016) Yo-El S. Ju et al.   ANNALS OF NEUROLOGY

Cause and prevention of demyelination in a model multiple sclerosis lesion

(2016) Roshni A. Desai et al.   ANNALS OF NEUROLOGY

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease

(2016) Christian Lambert et al.   BRAIN

Relative impact of amyloid-β, lacunes, and downstream imaging markers on cognitive trajectories

(2016) Hee Jin Kim et al.   BRAIN

Immunoregulation at the gliovascular unit in the healthy brain: A focus on Connexin 43

(2016) Anne-Cécile Boulay et al.   BRAIN BEHAVIOR AND IMMUNITY

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

(2016) Violeta Silva-Vargas et al.   Cell Stem Cell

Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease

(2016) Susana Muñoz Maniega et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral blood flow in small vessel disease: A systematic review and meta-analysis

(2016) Yulu Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

(2016) Kyle R. Biesecker et al.   JOURNAL OF NEUROSCIENCE

Binaural blood flow control by astrocytes: listening to synapses and the vasculature

(2016) Anusha Mishra   JOURNAL OF PHYSIOLOGY-LONDON

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

Structural network efficiency predicts conversion to dementia

(2016) Anil M. Tuladhar et al.   NEUROLOGY

Heterogeneous histopathology of cortical microbleeds in cerebral amyloid angiopathy

(2016) Susanne J. van Veluw et al.   NEUROLOGY

Cortical cerebral microinfarcts on 3T MRI

(2016) Saima Hilal et al.   NEUROLOGY

Rodent Models of Vascular Cognitive Impairment

(2016) Yi Yang et al.   Translational Stroke Research

Cell type specificity of neurovascular coupling in cerebral cortex

(2016) Hana Uhlirova et al.   eLife

Risk of Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis in Patients With Acute Ischemic Stroke and High Cerebral Microbleed Burden

(2016) Georgios Tsivgoulis et al.   JAMA Neurology

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage

(2015) Sergi Martinez-Ramirez et al.   Alzheimers & Dementia

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients

(2015) Susanne J. van Veluw et al.   Alzheimers & Dementia

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2015) Mitrajit Ghosh et al.   ANNALS OF NEUROLOGY

Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly

(2015) Prashanthi Vemuri et al.   BRAIN

Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

(2015) Aiqing Chen et al.   BRAIN

Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment

(2015) Zoe Arvanitakis et al.   Brain Structure & Function

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Transient isolated ocular motor abnormality related to perilesional edema of an acute medullary microbleed: A case report and review of the literatures

(2015) Woo-Jin Lee et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier

(2015) Azadeh Reyahi et al.   DEVELOPMENTAL CELL

A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

Gliovascular Disruption and Cognitive Deficits in a Mouse Model with Features of Small Vessel Disease

(2015) Philip R Holland et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline

(2015) Leif Østergaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?

(2015) Vesa Kiviniemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ion channel networks in the control of cerebral blood flow

(2015) Thomas A Longden et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review

(2015) Anna Poggesi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hydrocephalus in cerebral venous thrombosis

(2015) Susanna M. Zuurbier et al.   JOURNAL OF NEUROLOGY

The Effect of Body Posture on Brain Glymphatic Transport

(2015) H. Lee et al.   JOURNAL OF NEUROSCIENCE

Inspiration Is the Major Regulator of Human CSF Flow

(2015) S. Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

S100B and ADMA in cerebral small vessel disease and cognitive dysfunction

(2015) Qiang Gao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Vascular Inward Rectifier K+Channels as External K+Sensors in the Control of Cerebral Blood Flow

(2015) Thomas A. Longden et al.   MICROCIRCULATION

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis

(2015) Thomas T. van Sloten et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Vascular Imaging Abnormalities and Cognition

(2015) David S. Knopman et al.   STROKE

Long-Term Blood–Brain Barrier Permeability Changes in Binswanger Disease

(2015) Branko N. Huisa et al.   STROKE

Relationship Between White Matter Hyperintensities, Cortical Thickness, and Cognition

(2015) Anil M. Tuladhar et al.   STROKE

Predictors of Clinical Worsening in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

(2015) Hugues Chabriat et al.   STROKE

Microglia Plasticity During Health and Disease: An Immunological Perspective

(2015) Anat Shemer et al.   TRENDS IN IMMUNOLOGY

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

Lacunar Infarction and Small Vessel Disease: Pathology and Pathophysiology

(2015) Louis R Caplan   Journal of Stroke

Prevention and Management of Cerebral Small Vessel Disease

(2015) Vincent Mok et al.   Journal of Stroke

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

(2015) Tina Sartorius et al.   PLoS One

Microvascular Pathology and Morphometrics of Sporadic and Hereditary Small Vessel Diseases of the Brain

(2014) Lucinda J.L. Craggs et al.   BRAIN PATHOLOGY

CADASIL and CARASIL

(2014) Saara Tikka et al.   BRAIN PATHOLOGY

Thrombolysis in Acute Stroke Patients with Cerebral Small Vessel Disease

(2014) Leonardo Pantoni et al.   CEREBROVASCULAR DISEASES

Circulating Matrix Metalloproteinase-9 Level Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals

(2014) Yoon Kim et al.   EUROPEAN NEUROLOGY

Blood-Brain Barrier Dysfunction and Cerebral Small Vessel Disease (Arteriolosclerosis) in Brains of Older People

(2014) Leslie R. Bridges et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial

(2014) Lesly A Pearce et al.   LANCET NEUROLOGY

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition

(2014) Ming Yao et al.   NEUROBIOLOGY OF AGING

Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors

(2014) K. Miwa et al.   NEUROLOGY

Prestroke Statins, Progression of White Matter Hyperintensities, and Cognitive Decline in Stroke Patients with Confluent White Matter Hyperintensities

(2014) Yunyun Xiong et al.   Neurotherapeutics

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Effects of Sapropterin on Endothelium-Dependent Vasodilation in Patients With CADASIL

(2014) Renata De Maria et al.   STROKE

Number of Cerebral Microbleeds and Risk of Intracerebral Hemorrhage After Intravenous Thrombolysis

(2014) Steffen Dannenberg et al.   STROKE

Cognitive profile in patients with a first-ever lacunar infarct with and without silent lacunes: a comparative study

(2013) Lorena Blanco-Rojas et al.   BMC Neurology

Sublingual Microvascular Glycocalyx Dimensions in Lacunar Stroke Patients

(2013) Remy J.H. Martens et al.   CEREBROVASCULAR DISEASES

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period

(2013) Christina Whiteus et al.   NATURE

Estimating cerebral microinfarct burden from autopsy samples

(2013) M. B. Westover et al.   NEUROLOGY

Correction: Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study

(2013) Andrew J. Lawrence et al.   PLoS One

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

(2013) K. Baruch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Is There a Cerebral Lymphatic System?

(2013) J. J. Iliff et al.   STROKE

The Effect of Lacunar Infarcts on White Matter Tract Integrity

(2013) Yael D. Reijmer et al.   STROKE

Pathology and pathogenesis of vascular cognitive impairment—a critical update

(2013) Kurt A. Jellinger   Frontiers in Aging Neuroscience

Mechanisms of Neuronal Damage and Neuroprotection Underlying Ischemia/Reperfusion Injury after Physical Exercise

(2012) Yuchuan Ding   CURRENT DRUG TARGETS

The Locus Coeruleus-Norepinephrine Network Optimizes Coupling of Cerebral Blood Volume with Oxygen Demand

(2012) Lane K Bekar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral Microinfarcts: A Systematic Review of Neuropathological Studies

(2012) Manon Brundel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hereditary cerebral small vessel diseases: A review

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Incident subcortical infarcts induce focal thinning in connected cortical regions

(2012) M. Duering et al.   NEUROLOGY

Circulating IL-6 and CRP are associated with MRI findings in the elderly: The 3C-Dijon Study

(2012) C. L. Satizabal et al.   NEUROLOGY

Pericytes as a new target for pathological processes in CADASIL

(2012) Dorota Dziewulska et al.   NEUROPATHOLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation

(2011) Xiaoguang Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cerebral Microbleeds: Histopathological Correlation of Neuroimaging

(2011) A. Shoamanesh et al.   CEREBROVASCULAR DISEASES

Is the Spontaneously Hypertensive Stroke Prone Rat a Pertinent Model of Sub Cortical Ischemic Stroke? A Systematic Review

(2011) Emma L. Bailey et al.   International Journal of Stroke

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Brain regional angiogenic potential at the neurovascular unit during normal aging

(2011) Nivetha Murugesan et al.   NEUROBIOLOGY OF AGING

Progressive Gray Matter Atrophy in Lacunar Patients with Vascular Mild Cognitive Impairment

(2010) Marta Grau-Olivares et al.   CEREBROVASCULAR DISEASES

Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

(2010) A. A. Gouw et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Review: Sporadic cerebral amyloid angiopathy

(2010) J. Attems et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Effects of Perindopril-Based Lowering of Blood Pressure on Intracerebral Hemorrhage Related to Amyloid Angiopathy

(2010) Hisatomi Arima et al.   STROKE

Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study

(2009) Matthew Schrag et al.   ACTA NEUROPATHOLOGICA

Mild cognitive impairment in stroke patients with ischemic cerebral small-vessel disease: a forerunner of vascular dementia?

(2009) Marta Grau-Olivares et al.   Expert Review of Neurotherapeutics

Brain atrophy and cognition: Interaction with cerebrovascular pathology?

(2009) Majon Muller et al.   NEUROBIOLOGY OF AGING

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Impact of Lacunes and Microvascular Lesions on Poststroke Depression

(2009) Micaela Santos et al.   STROKE

Cognitive Consequences of Multiple Lacunes and Leukoaraiosis as Vascular Cognitive Impairment in Community-Dwelling Elderly Individuals

(2008) Hiroshi Koga et al.   Journal of Stroke & Cerebrovascular Diseases

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE

Understanding White Matter Disease: Imaging-Pathological Correlations in Vascular Cognitive Impairment

(2008) S. Black et al.   STROKE