The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke

(2018) Jens P. Dreier et al.   NEUROPHARMACOLOGY

General Anesthesia Inhibits the Activity of the “Glymphatic System”

(2018) Clement Gakuba et al.   Theranostics

Potential Modes of Intercellular α-Synuclein Transmission

(2017) Dario Valdinocci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular characterization of perivascular drainage pathways in the murine brain

(2017) Melanie-Jane Hannocks et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology

(2017) Per Borghammer   MOVEMENT DISORDERS

Cerebral magnetic resonance findings during enzyme replacement therapy in mucopolysaccharidosis

(2017) Yoshiko Matsubara et al.   PEDIATRIC RADIOLOGY

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicle communication pathways as regulatory targets of oncogenic transformation

(2017) Dongsic Choi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Arterial Pulsations cannot Drive Intramural Periarterial Drainage: Significance for Aβ Drainage

(2017) Alexandra K. Diem et al.   Frontiers in Neuroscience

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer’s disease-related microvascular cerebral amyloid angiopathy

(2016) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy

(2016) Vikram Puvenna et al.   BRAIN RESEARCH

Extracellular vesicles: interneural shuttles of complex messages

(2016) Eva-Maria Krämer-Albers et al.   CURRENT OPINION IN NEUROBIOLOGY

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series

(2016) Sharon Baughman Shively et al.   LANCET NEUROLOGY

CSF generation by pineal gland results in a robust melatonin circadian rhythm in the third ventricle as an unique light/dark signal

(2016) Dun-Xian Tan et al.   MEDICAL HYPOTHESES

Progress in Drug Treatment of Cerebral Edema

(2016) Y. Y. Deng et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cerebral Edema in Traumatic Brain Injury

(2016) Ethan A. Winkler et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Changes in the composition of brain interstitial ions control the sleep-wake cycle

(2016) Fengfei Ding et al.   SCIENCE

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Venular degeneration leads to vascular dysfunction in a transgenic model of Alzheimer’s disease

(2015) Aaron Y. Lai et al.   BRAIN

Dynamic regulation of aquaporin-4 water channels in neurological disorders

(2015) Ying Hsu et al.   CROATIAN MEDICAL JOURNAL

A balanced view of choroid plexus structure and function: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration

(2015) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging

(2015) Daniel J. Wolak et al.   JOURNAL OF CONTROLLED RELEASE

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inspiration Is the Major Regulator of Human CSF Flow

(2015) S. Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Muddying the water in brain edema?

(2015) Alex J. Smith et al.   TRENDS IN NEUROSCIENCES

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

(2015) Natalya Korogod et al.   eLife

A brief history of prions

(2015) Mark D. Zabel et al.   Pathogens and Disease

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

(2015) Maddalena Costanzo et al.   BIOCHEMICAL JOURNAL

Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain

(2014) Laura Kervezee et al.   AAPS Journal

Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow–Robin perivascular spaces

(2014) Russel J. Reiter et al.   Brain Structure & Function

Functional Role of Connexins and Pannexins in the Interaction Between Vascular and Nervous System

(2014) Pablo S. Gaete et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin from Cerebrospinal Fluid but Not from Blood Reaches Sheep Cerebral Tissues Under Physiological Conditions

(2014) C. Legros et al.   JOURNAL OF NEUROENDOCRINOLOGY

Outcome markers for clinical trials in cerebral amyloid angiopathy

(2014) Steven M Greenberg et al.   LANCET NEUROLOGY

Cerebral edema in children with diabetic ketoacidosis: vasogenic rather than cellular?

(2014) Robert C Tasker et al.   PEDIATRIC DIABETES

The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain

(2014) Reynold Spector et al.   Molecular Brain

Aquaporin and brain diseases

(2013) Jérôme Badaut et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

(2013) Daniel J. Wolak et al.   MOLECULAR PHARMACEUTICS

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Is There a Cerebral Lymphatic System?

(2013) J. J. Iliff et al.   STROKE

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Brain and Spinal MR Imaging Findings in Mucopolysaccharidoses: A Review

(2012) D.I. Zafeiriou et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cellular mechanisms of protein aggregate propagation

(2012) Brandon B. Holmes et al.   CURRENT OPINION IN NEUROLOGY

Vascular dementia: Different forms of vessel disorders contribute to the development of dementia in the elderly brain

(2012) Dietmar Rudolf Thal et al.   EXPERIMENTAL GERONTOLOGY

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

(2012) Leslie L Muldoon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil

(2012) Justin P. Kinney et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Organophosphate-induced brain damage: Mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies

(2012) Yun Chen   NEUROTOXICOLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The measurement of CSF flow through the aqueduct in normal and hydrocephalic children: from where does it come, to where does it go?

(2011) Grant A. Bateman et al.   CHILDS NERVOUS SYSTEM

Insulin-Like Growth Factor-II Uptake Into Choroid Plexus and Brain of Young and Old Sheep

(2011) R. L. Chen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers

(2011) Diane Slats et al.   NEUROBIOLOGY OF AGING

Sodium-Dependent Vitamin C Transporter 2 (SVCT2) Expression and Activity in Brain Capillary Endothelial Cells after Transient Ischemia in Mice

(2011) Burkhard Gess et al.   PLoS One

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebrospinal Fluid Flow Dynamics in the Central Nervous System

(2010) Brian Sweetman et al.   ANNALS OF BIOMEDICAL ENGINEERING

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Enlarged Perivascular Spaces on MRI Are a Feature of Cerebral Small Vessel Disease

(2010) Fergus N. Doubal et al.   STROKE

Pathology and new players in the pathogenesis of brain edema

(2009) Sukriti Nag et al.   ACTA NEUROPATHOLOGICA

An emerging role of mast cells in cerebral ischemia and hemorrhage

(2009) Daniel Strbian et al.   ANNALS OF MEDICINE

Calcium diffusion enhanced after cleavage of negatively charged components of brain extracellular matrix by chondroitinase ABC

(2009) Sabina Hrabětová et al.   JOURNAL OF PHYSIOLOGY-LONDON

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Tight junctions and the modulation of barrier function in disease

(2008) Carola Förster   HISTOCHEMISTRY AND CELL BIOLOGY

Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change

(2008) X. Yao et al.   JOURNAL OF NEUROSCIENCE

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS

In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate

(2008) R. G. Thorne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA