Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

(2018) N. Gorlé et al.   BRAIN BEHAVIOR AND IMMUNITY

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

(2018) Steffen E. Storck et al.   BRAIN BEHAVIOR AND IMMUNITY

Treatment-resistant depression and peripheral C-reactive protein

(2018) Samuel R. Chamberlain et al.   BRITISH JOURNAL OF PSYCHIATRY

Herpes Zoster and Dementia

(2018) Vincent Chin-Hung Chen et al.   JOURNAL OF CLINICAL PSYCHIATRY

Aging exacerbates development of cerebral microbleeds in a mouse model

(2018) Rachita K. Sumbria et al.   Journal of Neuroinflammation

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

(2018) Nian-Sheng Tzeng et al.   Neurotherapeutics

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

(2018) Michelle A. Erickson et al.   PHARMACOLOGICAL REVIEWS

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

(2018) Ana Luisa Cardoso et al.   AGEING RESEARCH REVIEWS

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

(2018) Svetlana M. Stamatovic et al.   NEUROBIOLOGY OF DISEASE

Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

(2018) Min Hee Park et al.   NEURON

Blood-brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy

(2018) Sofia Gustafsson et al.   NEUROPHARMACOLOGY

Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity

(2018) Michelle A. Erickson et al.   PLoS One

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

(2018) Tamas Fulop et al.   Frontiers in Aging Neuroscience

Klotho controls the brain–immune system interface in the choroid plexus

(2018) Lei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

(2018) Gabor A. Fulop et al.   GeroScience

Gut reactions: How the blood–brain barrier connects the microbiome and the brain

(2017) Aric F Logsdon et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Microbiome-Gut-Brain Axis in Health and Disease

(2017) Timothy G. Dinan et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Neurovascular unit crosstalk: Pericytes and astrocytes modify cytokine secretion patterns of brain endothelial cells

(2017) William A Banks et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm

(2017) Aakanksha Jain et al.   JOURNAL OF IMMUNOLOGY

Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood–Brain Barrier

(2017) Shingo Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Obesity: GDF15 tells the brain to lose weight

(2017) M. Teresa Villanueva   NATURE REVIEWS DRUG DISCOVERY

The blood-brain barrier in Alzheimer's disease

(2017) Elena Zenaro et al.   NEUROBIOLOGY OF DISEASE

The quantification of blood-brain barrier disruption using dynamic contrast-enhanced magnetic resonance imaging in aging rhesus monkeys with spontaneous type 2 diabetes mellitus

(2017) Ziqian Xu et al.   NEUROIMAGE

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis

(2017) J. Duncombe et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Age-associated changes in the blood-brain barrier: comparative studies in human and mouse

(2017) E. F. Goodall et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

(2017) Yumei Xiong et al.   Science Translational Medicine

Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome

(2017) Jared D. Hoffman et al.   Frontiers in Aging Neuroscience

Clostridium difficile infection in the elderly: an update on management

(2017) Tomefa Asempa et al.   Clinical Interventions in Aging

Aging, Obesity, and Inflammatory Age-Related Diseases

(2017) Daniela Frasca et al.   Frontiers in Immunology

Neuronal Cytoskeletal Dynamic Modification and Neurodegeneration Induced by Infection with Herpes Simplex Virus Type 1

(2017) Ángara Zambrano et al.   JOURNAL OF ALZHEIMERS DISEASE

Human Truncated Tau is Using a Different Mechanism from Amyloid-β to Damage the Blood-Brain Barrier

(2017) Andrej Kovac et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased risk of dementia following herpes zoster ophthalmicus

(2017) Ming-Chieh Tsai et al.   PLoS One

The biology of the metabolic syndrome and aging

(2016) Ligia J. Dominguez et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice

(2016) Vanessa Dubois et al.   ENDOCRINOLOGY

Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction

(2016) Stijn Bonte et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Tau Proteins Cross the Blood-Brain Barrier

(2016) William A. Banks et al.   JOURNAL OF ALZHEIMERS DISEASE

Breakdown of the Cerebrovasculature and Blood-Brain Barrier: A Mechanistic Link Between Diabetes Mellitus and Alzheimer’s Disease

(2016) Eric L. Goldwaser et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic depletion of gonadal testosterone leads to blood–brain barrier dysfunction and inflammation in male mice

(2016) Afnan Atallah et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice

(2016) Alexis M Stranahan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

(2016) Rodney M. Ritzel et al.   JOURNAL OF IMMUNOLOGY

Albumin microvascular leakage in brains with diabetes mellitus

(2016) Ryuji Fujihara et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Antidiabetic drugs restore abnormal transport of amyloid-β across the blood–brain barrier and memory impairment in db / db mice

(2016) Fang Chen et al.   NEUROPHARMACOLOGY

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

(2016) Megan W. Bourassa et al.   NEUROSCIENCE LETTERS

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

(2015) Michael E. Walsh et al.   AGING CELL

The interface of depression and cardiovascular disease: therapeutic implications

(2015) Fred Seligman et al.   Annals of the New York Academy of Sciences

Sleep fragmentation and sepsis differentially impact blood–brain barrier integrity and transport of tumor necrosis factor-α in aging

(2015) Mark R. Opp et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Circulating Growth Differentiation Factor 11/8 Levels Decline With AgeNovelty and Significance

(2015) Tommaso Poggioli et al.   CIRCULATION RESEARCH

Cellular senescence and the aging brain

(2015) Shankar J. Chinta et al.   EXPERIMENTAL GERONTOLOGY

Anti–IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus

(2015) Jiyong Zhang et al.   FASEB JOURNAL

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

(2015) Leon M. Tai et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium

(2015) Yuri Persidsky et al.   Journal of Neuroimmune Pharmacology

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

Beyond Urinary Tract Infections (UTIs) and Delirium

(2015) JUNG HEE JENNIFER CHAE et al.   Journal of Psychiatric Practice

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations

(2015) Catherine Chiu et al.   NEUROBIOLOGY OF AGING

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes

(2015) Abhay P. Sagare et al.   NEUROSCIENCE LETTERS

Aging Population

(2015) Deborah Ellison et al.   NURSING CLINICS OF NORTH AMERICA

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier

(2015) Claudio Mauro et al.   Frontiers in Immunology

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

(2015) Laura J Blair et al.   Acta Neuropathologica Communications

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

(2015) Tina Sartorius et al.   PLoS One

The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimer's Disease?

(2014) Ethan A. Winkler et al.   BRAIN PATHOLOGY

Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro

(2014) Christian Pieper et al.   BRAIN RESEARCH

A systems biology approach to the effect of aging, immunosenescence and vaccine response

(2014) Gregory A Poland et al.   CURRENT OPINION IN IMMUNOLOGY

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation

(2014) Michal Schwartz et al.   JOURNAL OF AUTOIMMUNITY

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

(2014) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Blood-derived rejuvenation

(2014) Darran Yates   NATURE REVIEWS NEUROSCIENCE

Correction: Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2014) Elena Biagi et al.   PLoS One

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Drug and xenobiotic biotransformation in the blood–brain barrier: a neglected issue

(2014) José A. G. Agúndez et al.   Frontiers in Cellular Neuroscience

A Comprehensive Review on Metabolic Syndrome

(2014) Jaspinder Kaur   Cardiology Research and Practice

Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway

(2013) Tianyi Jiang et al.   AGING CELL

CNS-specific T cells shape brain function via the choroid plexus

(2013) Kuti Baruch et al.   BRAIN BEHAVIOR AND IMMUNITY

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Cerebrospinal Fluid Secretion by the Choroid Plexus

(2013) Helle H. Damkier et al.   PHYSIOLOGICAL REVIEWS

Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention

(2013) Fan Ding et al.   PLoS One

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

(2012) Linda Engström et al.   ENDOCRINOLOGY

P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender

(2012) Daniëlle M. E. van Assema et al.   MOLECULAR IMAGING AND BIOLOGY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Ageing and gut microbes: Perspectives for health maintenance and longevity

(2012) Elena Biagi et al.   PHARMACOLOGICAL RESEARCH

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Age-related changes in CD8 T cell homeostasis and immunity to infection

(2012) Janko Nikolich-Žugich et al.   SEMINARS IN IMMUNOLOGY

Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: Multiplex quantification with path analysis

(2011) Michelle A. Erickson et al.   BRAIN BEHAVIOR AND IMMUNITY

Mammalian Sirt1: insights on its biological functions

(2011) Shahedur Rahman et al.   Cell Communication and Signaling

Gain and Loss of T Cell Subsets in Old Age—Age-Related Reshaping of the T Cell Repertoire

(2011) Christoph R. Arnold et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF

(2011) Shinya Dohgu et al.   Journal of Neuroinflammation

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Development of a serum profile for healthy aging

(2010) Lauri O. Byerley et al.   AGE

Age effects on B cells and humoral immunity in humans

(2010) Daniela Frasca et al.   AGEING RESEARCH REVIEWS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

Quantification of butyryl CoA:acetate CoA-transferase genes reveals different butyrate production capacity in individuals according to diet and age

(2010) Berit Hippe et al.   FEMS MICROBIOLOGY LETTERS

The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury

(2010) Tetsuhiro Higashida et al.   JOURNAL OF NEUROSURGERY

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The metabolic syndrome in older persons: a loosely defined constellation of symptoms or a distinct entity?

(2009) John E. Morley et al.   AGE AND AGEING

Depression in Older Adults

(2009) Amy Fiske et al.   Annual Review of Clinical Psychology

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences

(2009) Jonathan P. Godbout et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Is it appropriate to use albumin CSF/plasma ratio to assess blood brain barrier permeability?

(2009) Ruo-Li Chen   NEUROBIOLOGY OF AGING

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Biology of Immune Responses to Vaccines in Elderly Persons

(2008) Birgit Weinberger et al.   CLINICAL INFECTIOUS DISEASES

Pericytes: Pluripotent Cells of the Blood Brain Barrier

(2008) Paula Dore-Duffy   CURRENT PHARMACEUTICAL DESIGN

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Age-related changes in choroid plexus and blood–cerebrospinal fluid barrier function in the sheep

(2008) R.L. Chen et al.   EXPERIMENTAL GERONTOLOGY

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood–brain barrier

(2008) William A. Banks et al.   PEPTIDES

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

(2007) Jing Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING

The inflammatory response to social defeat is increased in older mice

(2007) Steven G. Kinsey et al.   PHYSIOLOGY & BEHAVIOR