Klotho controls the brain–immune system interface in the choroid plexus

Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

(2017) George Dalton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide

(2017) Ling Chen et al.   Scientific Reports

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

(2016) Matthew J. Simon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

The in vivo effects of a fraction from Dioscorea spongiosa on glucocorticoid-induced osteoporosis

(2016) Na Han et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Choroid Plexus in Healthy and Diseased Brain

(2016) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology

(2016) Aleksandra Deczkowska et al.   TRENDS IN IMMUNOLOGY

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease

(2015) Sandro Dá Mesquita et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular Basis of Klotho: From Gene to Function in Aging

(2015) Yuechi Xu et al.   ENDOCRINE REVIEWS

Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production

(2015) M. P. Lun et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

(2015) Susan L. Patterson   NEUROPHARMACOLOGY

Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

(2015) Anna Massó et al.   PLoS One

Neurocognitive Aging and the Hippocampus across Species

(2015) Stephanie L. Leal et al.   TRENDS IN NEUROSCIENCES

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

BioAge: Toward a multi-determined, mechanistic account of cognitive aging

(2014) Correne A. DeCarlo et al.   AGEING RESEARCH REVIEWS

Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho

(2014) Ci-Di Chen et al.   BIOCHEMISTRY

Expression of Nampt in Hippocampal and Cortical Excitatory Neurons Is Critical for Cognitive Function

(2014) L. R. Stein et al.   JOURNAL OF NEUROSCIENCE

The Kidney Is the Principal Organ Mediating Klotho Effects

(2014) K. Lindberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho Gene Deficiency Causes Salt-Sensitive Hypertension via Monocyte Chemotactic Protein-1/CC Chemokine Receptor 2-Mediated Inflammation

(2014) X. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases

(2014) Eiji Yoshihara et al.   Frontiers in Immunology

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

CNS-specific T cells shape brain function via the choroid plexus

(2013) Kuti Baruch et al.   BRAIN BEHAVIOR AND IMMUNITY

Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood

(2013) Sarah M. Clinton et al.   BRAIN RESEARCH

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Impact of aging brain circuits on cognition

(2013) Rachel D. Samson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Interferons in the central nervous system: A few instruments play many tunes

(2013) Trevor Owens et al.   GLIA

Microglial Activation Milieu Controls Regulatory T Cell Responses

(2013) F. Ebner et al.   JOURNAL OF IMMUNOLOGY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

(2013) Richard D. Semba et al.   NEUROSCIENCE LETTERS

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

(2013) K. Baruch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Bone Marrow-derived Macrophage Production

(2013) Virginie Trouplin et al.   Jove-Journal of Visualized Experiments

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice

(2012) Tso-Hsiao Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The immunology of neurodegeneration

(2012) Eva Czirr et al.   JOURNAL OF CLINICAL INVESTIGATION

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

Targeted Deletion of Klotho in Kidney Distal Tubule Disrupts Mineral Metabolism

(2012) H. Olauson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Nuclear localization of Klotho in brain: an anti-aging protein

(2012) Dwight C. German et al.   NEUROBIOLOGY OF AGING

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

(2012) Julie A. Harris et al.   PLoS One

A molecular characterization of the choroid plexus and stress-induced gene regulation

(2012) M Sathyanesan et al.   Translational Psychiatry

Thioredoxin Interacting Protein: Redox Dependent and Independent Regulatory Mechanisms

(2011) Oded N. Spindel et al.   ANTIOXIDANTS & REDOX SIGNALING

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice

(2011) M. Cisse et al.   JOURNAL OF NEUROSCIENCE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Klotho suppresses RIG-I-mediated senescence-associated inflammation

(2011) Feng Liu et al.   NATURE CELL BIOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions

(2009) Lorena Perrone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

(2008) M. Shiozaki et al.   NEUROSCIENCE

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA