Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer’s Disease and in Down Syndrome Dementia

Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer’s Disease Pathology in Down Syndrome

(2018) Ruma Raha-Chowdhury et al.   JOURNAL OF ALZHEIMERS DISEASE

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

(2017) Harutsugu Tatebe et al.   Molecular Neurodegeneration

The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis

(2017) Tiina Annus et al.   NEUROBIOLOGY OF AGING

Increased levels of plasma total tau in adult Down syndrome

(2017) Takashi Kasai et al.   PLoS One

The pattern of amyloid accumulation in the brains of adults with Down syndrome

(2016) Tiina Annus et al.   Alzheimers & Dementia

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

(2016) Xianyuan Xiang et al.   EMBO Molecular Medicine

Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model

(2016) Animesh Alexander Raha et al.   JOURNAL OF ALZHEIMERS DISEASE

The Choroid Plexus in Healthy and Diseased Brain

(2016) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s disease

(2015) Arthur A. Bergen et al.   BMC GENOMICS

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

(2015) Delphine Demeestere et al.   DRUG DISCOVERY TODAY

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production

(2015) M. P. Lun et al.   JOURNAL OF NEUROSCIENCE

Development and functions of the choroid plexus–cerebrospinal fluid system

(2015) Melody P. Lun et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?

(2015) Rudolph E. Tanzi   NEW ENGLAND JOURNAL OF MEDICINE

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

(2013) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome

(2012) Ana M. Cárdenas et al.   ARCHIVES OF MEDICAL RESEARCH

Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood-CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

(2012) R. E. Vandenbroucke et al.   JOURNAL OF NEUROSCIENCE

Microglial pathology in Down syndrome

(2011) Qing-Shan Xue et al.   ACTA NEUROPATHOLOGICA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Mortality, Dementia, and Apolipoprotein E Genotype in Elderly White Women in the United States

(2009) Deborah M. Little et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH