Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid

Xanthoceraside attenuates amyloid β peptide 1-42 -induced memory impairments by reducing neuroinflammatory responses in mice

(2018) Yue Qi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer’s Disease

(2018) Jinze Li et al.   Frontiers in Aging Neuroscience

Supplementation of Nitric Oxide Attenuates AβPP and BACE1 Protein in Cerebral Microcirculation of eNOS-Deficient Mice

(2018) Susan A. Austin et al.   JOURNAL OF ALZHEIMERS DISEASE

K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

(2018) Ji Yeon Choi et al.   Journal of Neuroinflammation

Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries

(2017) Livius V d’Uscio et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NF-κB dependent up-regulation of TRPC6 by Aβ in BV-2 microglia cells increases COX-2 expression and contributes to hippocampus neuron damage

(2017) Na Liu et al.   NEUROSCIENCE LETTERS

Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium

(2017) Livius V. d'Uscio et al.   PHYSIOLOGY

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

(2017) Connor A. Emdin et al.   CIRCULATION

Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer’s DiseaseNovelty and Significance

(2016) Susan A. Austin et al.   CIRCULATION RESEARCH

Thirty Years of Saying NO

(2016) Paul M. Vanhoutte et al.   CIRCULATION RESEARCH

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

(2016) Matthew R. Reynolds et al.   Molecular Neurodegeneration

Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations

(2015) Kenzo Koizumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

(2015) Giuseppe Faraco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

(2015) Xing-Lin Tan et al.   Molecular Neurodegeneration

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

(2014) Ana Catarina R. G. Fonseca et al.   MOLECULAR NEUROBIOLOGY

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology

(2013) Susan A. Austin et al.   JOURNAL OF NEUROCHEMISTRY

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

(2013) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protecting against vascular disease in brain

(2011) Frank M. Faraci   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification and biology of α-secretase

(2011) Valérie Vingtdeux et al.   JOURNAL OF NEUROCHEMISTRY

Differential regulation of BACE1 expression by oxidative and nitrosative signals

(2011) Young-Don Kwak et al.   Molecular Neurodegeneration

Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme

(2011) Crystal M. Cordes et al.   PLoS One

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Bone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress–Dependent Cyclooxygenase-2 Upregulation

(2010) Wing Tak Wong et al.   CIRCULATION RESEARCH

Endothelial Nitric Oxide Modulates Expression and Processing of Amyloid Precursor Protein

(2010) Susan A. Austin et al.   CIRCULATION RESEARCH

Endothelial Dysfunction: The Common Consequence in Diabetes and Hypertension

(2010) Wing Tak Wong et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cardiovascular Risk Factors and Incident Alzheimer Disease

(2009) Christianna Purnell et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

TP Receptor Antagonism: A New Concept in Atherothrombosis and Stroke Prevention

(2009) Angel Chamorro   CEREBROVASCULAR DISEASES

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

Structural Characterization of the Ectodomain of a Disintegrin and Metalloproteinase-22 (ADAM22), a Neural Adhesion Receptor Instead of Metalloproteinase

(2009) Heli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statin's Excitoprotection Is Mediated by sAPP and the Subsequent Attenuation of Calpain-Induced Truncation Events, Likely via Rho-ROCK Signaling

(2009) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Mediates a Tyrosine Kinase-Dependent Activation Response in Endothelial Cells

(2009) S. A. Austin et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta peptide-activated signal pathways in human platelets

(2008) Ming Y. Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE−/− mice

(2008) Susan A. Austin et al.   NEUROBIOLOGY OF AGING

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells

(2007) Mireia Coma et al.   NEUROBIOLOGY OF AGING