Macrophages as a therapeutic target to promote diabetic wound healing

IL-25 improves diabetic wound healing through stimulating M2 macrophage polarization and fibroblast activation

(2022) Shiyan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Macrophages in dermatology: pathogenic roles and targeted therapeutics

(2021) Drew Kuraitis et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

An inflammatory triangle in Sarcoidosis: PPAR-γ, immune microenvironment, and inflammation

(2021) Parnia Jabbari et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing

(2021) Biyun Lan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Immunology of Acute and Chronic Wound Healing

(2021) Kamila Raziyeva et al.   Biomolecules

Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation

(2021) Yidi Wang et al.   EXPERIMENTAL EYE RESEARCH

Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds

(2021) Savannah M. Aitcheson et al.   MOLECULES

Macrophage Related Chronic Inflammation in Non-Healing Wounds

(2021) Meirong Li et al.   Frontiers in Immunology

The Role of Extracellular Matrix in Skin Wound Healing

(2021) Nikolai N. Potekaev et al.   Journal of Clinical Medicine

Standards for the development and methodology of the 2019 International Working Group on the Diabetic Foot guidelines

(2020) S.A. Bus et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

IRF5 Acts as a Potential Therapeutic Marker in Inflammatory Bowel Diseases

(2020) Yonghong Yang et al.   INFLAMMATORY BOWEL DISEASES

Activation of PPAR-γ induces macrophage polarization and reduces neutrophil migration mediated by heme oxygenase 1

(2020) Henrique Ballassini Abdalla et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hyperbranched cationic polysaccharide derivatives for efficient siRNA delivery and diabetic wound healing enhancement

(2020) Biyun Lan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Macrophage–NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes

(2020) Hong-Bin Lin et al.   Neuroscience Bulletin

Type III Secretion Protein, PcrV, Impairs Pseudomonas aeruginosa Biofilm Formation by Increasing M1 Macrophage-Mediated Anti-bacterial Activities

(2020) Hua Yu et al.   Frontiers in Microbiology

Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway

(2020) Fatema Al-Rashed et al.   Cells

Tissue Stem Cells: Architects of Their Niches

(2020) Elaine Fuchs et al.   Cell Stem Cell

Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing

(2020) Le-Ping Yan et al.   Materials Science & Engineering C-Materials for Biological Applications

NLRP3 Activation Induced by Neutrophil Extracellular Traps Sustains Inflammatory Response in the Diabetic Wound

(2019) Dan Liu et al.   CLINICAL SCIENCE

New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice

(2019) Jacqueline C. Silva et al.   Advances in Wound Care

Skin Wounding–Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency

(2019) Pijus K. Barman et al.   JOURNAL OF IMMUNOLOGY

Inhibitor of growth 4 affects hypoxia-induced migration and angiogenesis regulation in retinal pigment epithelial cells

(2019) Yang Du et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Dynamics of the Skin’s Immune System

(2019) Alan V. Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing

(2019) Pijus K. Barman et al.   JOURNAL OF PATHOLOGY

Macrophage Polarization in Physiological and Pathological Pregnancy

(2019) Yongli Yao et al.   Frontiers in Immunology

Naturally-occurring bacterial cellulose-hyperbranched cationic polysaccharide derivative/MMP-9 siRNA composite dressing for wound healing enhancement in diabetic rats

(2019) Na Li et al.   Acta Biomaterialia

Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors

(2019) Jingjing Gan et al.   BIOMATERIALS

High glucose environment induces M1 macrophage polarization that impairs keratinocyte migration via TNF-α: An important mechanism to delay the diabetic wound healing

(2019) Shu-Mei Huang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-κB-mediated inflammatory genes

(2018) YiFeng Yuan et al.   BIOSCIENCE REPORTS

Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus

(2018) Byungji Kim et al.   Nature Communications

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

(2018) Paulina Krzyszczyk et al.   Frontiers in Physiology

Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia

(2018) Tomoya Terashima et al.   Molecular Therapy-Nucleic Acids

Advances and challenges in targeting IRF5, a key regulator of inflammation

(2018) Hannah Almuttaqi et al.   FEBS Journal

Resurgence of Diabetes-Related Nontraumatic Lower-Extremity Amputation in the Young and Middle-Aged Adult U.S. Population

(2018) Linda S. Geiss et al.   DIABETES CARE

Transcriptional profiling identifies novel regulators of macrophage polarization

(2018) Kimberline Y. Gerrick et al.   PLoS One

PKCζ as a promising therapeutic target for TNFα-induced inflammatory disorders in chronic cutaneous wounds

(2017) Jian Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Tissue-specific contribution of macrophages to wound healing

(2017) Carlos M. Minutti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

(2017) Stephanie A. Amici et al.   Frontiers in Immunology

Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury

(2017) Nadine Graubardt et al.   Frontiers in Immunology

Silencing TNFα with lipidoid nanoparticles downregulates both TNFα and MCP-1 in an in vitro co-culture model of diabetic foot ulcers

(2016) Lisa N. Kasiewicz et al.   Acta Biomaterialia

Delta-Like Ligand 4-Notch Signaling in Macrophage Activation

(2016) Toshiaki Nakano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design

(2016) Molly E Ogle et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction

(2016) Chi Liu et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Nanoparticle-Delivered IRF5 siRNA Facilitates M1 to M2 Transition, Reduces Demyelination and Neurofilament Loss, and Promotes Functional Recovery After Spinal Cord Injury in Mice

(2016) Jun Li et al.   INFLAMMATION

NADPH Oxidases Are Essential for Macrophage Differentiation

(2016) Qing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiogenesis and wound repair: when enough is enough

(2016) Luisa A. DiPietro   JOURNAL OF LEUKOCYTE BIOLOGY

Clustering siRNA conjugates for MMP-responsive therapeutics in chronic wounds of diabetic animals

(2016) Hye Sung Kim et al.   Nanoscale

Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing

(2016) John R. Martin et al.   Advanced Healthcare Materials

siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery

(2015) Maria João Gomes et al.   AGEING RESEARCH REVIEWS

Tissue-resident macrophages: then and now

(2015) Luke C. Davies et al.   IMMUNOLOGY

Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment

(2015) Xiaoling Wang et al.   JOURNAL OF CONTROLLED RELEASE

Collagen Turnover in Wound Repair––A Macrophage Connection

(2015) Liisa M. Nissinen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophage PPARγ and impaired wound healing in type 2 diabetes

(2015) Rita E Mirza et al.   JOURNAL OF PATHOLOGY

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

(2015) Elise Dalmas et al.   NATURE MEDICINE

siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown

(2015) Pratik S. Randeria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and epigenetic basis of macrophage polarized activation

(2015) Chiara Porta et al.   SEMINARS IN IMMUNOLOGY

Macrophage peroxisome proliferator-activated receptor γ deficiency delays skin wound healing through impairing apoptotic cell clearance in mice

(2015) H Chen et al.   Cell Death & Disease

Myelin damage and repair in pathologic CNS: challenges and prospects

(2015) Arsalan Alizadeh et al.   Frontiers in Molecular Neuroscience

Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring

(2015) Meilang Xue et al.   Advances in Wound Care

Cell surface engineering to enhance mesenchymal stem cell migration toward an SDF-1 gradient

(2014) Young-Wook Won et al.   BIOMATERIALS

Fractional factorial design to investigate stromal cell regulation of macrophage plasticity

(2014) Jeffrey A. Barminko et al.   BIOTECHNOLOGY AND BIOENGINEERING

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Synergistic Interactions of Pseudomonas aeruginosa and Staphylococcus aureus in anIn VitroWound Model

(2014) Stephanie DeLeon et al.   INFECTION AND IMMUNITY

Cationic star-shaped polymer as an siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats

(2014) Yan Li et al.   International Journal of Nanomedicine

Electrophilic Lipid Mediator 15-Deoxy- 12,14-Prostaglandin J2 Modifies Glucocorticoid Signaling via Receptor SUMOylation

(2014) V. Paakinaho et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular matrix and wound healing

(2014) F.X. Maquart et al.   PATHOLOGIE BIOLOGIE

The Monocyte to Macrophage Transition in the Murine Sterile Wound

(2014) Meredith J. Crane et al.   PLoS One

Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses

(2014) Nadine Jetten et al.   PLoS One

Advances in skin grafting and treatment of cutaneous wounds

(2014) B. K. Sun et al.   SCIENCE

Myeloid cell dysfunction and the pathogenesis of the diabetic chronic wound

(2014) Kate Wicks et al.   SEMINARS IN IMMUNOLOGY

Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

(2014) Kevin M. Vannella et al.   PLoS Pathogens

The Role of the Extracellular Matrix Components in Cutaneous Wound Healing

(2014) Pawel Olczyk et al.   Biomed Research International

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Phenotypic Transitions of Macrophages Orchestrate Tissue Repair

(2013) Margaret L. Novak et al.   AMERICAN JOURNAL OF PATHOLOGY

ROS sets the stage for macrophage differentiation

(2013) Anthony Covarrubias et al.   CELL RESEARCH

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

Effect of activated autologous monocytes/macrophages on wound healing in a rodent model of experimental diabetes

(2013) Xiao-yan Gu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

(2013) Gabriel Courties et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Discrete functions of M 2a and M 2c macrophage subsets determine their relative efficacy in treating chronic kidney disease

(2013) Junyu Lu et al.   KIDNEY INTERNATIONAL

Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization

(2013) Roman Günthner et al.   MEDIATORS OF INFLAMMATION

IRF5 Is a Specific Marker of Inflammatory MacrophagesIn Vivo

(2013) Miriam Weiss et al.   MEDIATORS OF INFLAMMATION

IL-33 accelerates cutaneous wound healing involved in upregulation of alternatively activated macrophages

(2013) Hui Yin et al.   MOLECULAR IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model

(2013) Nadine Jetten et al.   PLoS One

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

(2013) Austin Nuschke   Organogenesis

Th17 cells in type 1 diabetes

(2012) Shiying Shao et al.   CELLULAR IMMUNOLOGY

IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages

(2012) Hui-Rong Jiang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-33 Is hepatoprotective during liver ischemia/reperfusion in mice

(2012) Nozomu Sakai et al.   HEPATOLOGY

Reduced Il17a Expression Distinguishes a Ly6c lo MHCII hi Macrophage Population Promoting Wound Healing

(2012) Mathieu P. Rodero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

(2012) D. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Embryonic stem cell-derived M2-like macrophages delay cutaneous wound healing

(2012) Daniela Dreymueller et al.   WOUND REPAIR AND REGENERATION

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Hospital Epidemiology and Infection Control in Acute-Care Settings

(2011) E. R. M. Sydnor et al.   CLINICAL MICROBIOLOGY REVIEWS

Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice

(2011) Rita Mirza et al.   CYTOKINE

A Stepwise Approach to Insulin Therapy in Patients with Type 2 Diabetes Mellitus and Basal Insulin Treatment Failure

(2011) Mayer Davidson et al.   Endocrine Practice

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Macrophages in skin injury and repair

(2011) Babak Mahdavian Delavary et al.   IMMUNOBIOLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

The influence of interleukin-4 on ligament healing

(2011) Connie S. Chamberlain et al.   WOUND REPAIR AND REGENERATION

Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing

(2011) Gillian S. Ashcroft et al.   WOUND REPAIR AND REGENERATION

Engineering RNA for Targeted siRNA Delivery and Medical Application

(2010) Peixuan Guo et al.   ADVANCED DRUG DELIVERY REVIEWS

Hard to heal pressure ulcers (stage III–IV): Efficacy of injected activated macrophage suspension (AMS) as compared with standard of care (SOC) treatment controlled trial

(2010) Adi Zuloff-Shani et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice

(2010) Savita Khanna et al.   PLoS One

Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing

(2010) Qun-Zhou Zhang et al.   STEM CELLS

Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*

(2010) Kavitha Subramaniam et al.   International Wound Journal

Selective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice

(2009) Rita Mirza et al.   AMERICAN JOURNAL OF PATHOLOGY

A Transgenic Mouse Model of Inducible Macrophage Depletion

(2009) Itamar Goren et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of MCP-1 in tumor necrosis factor-α-induced endothelial dysfunction in type 2 diabetic mice

(2009) Jiyeon Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

(2009) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

The phenotype of murine wound macrophages

(2009) Jean M. Daley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

The skin: an indispensable barrier

(2008) Ehrhardt Proksch et al.   EXPERIMENTAL DERMATOLOGY

Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications

(2008) Chuan Huang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

IL-33 reduces the development of atherosclerosis

(2008) Ashley M. Miller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE