IRF5 Acts as a Potential Therapeutic Marker in Inflammatory Bowel Diseases

Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis

(2019) Bharati Matta et al.   CYTOKINE

Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens

(2019) Surya P. Pandey et al.   Mucosal Immunology

IL-10 signaling in dendritic cells controls IL-1β-mediated IFNγ secretion by human CD4+ T cells: relevance to inflammatory bowel disease

(2019) S. Veenbergen et al.   Mucosal Immunology

Diverse mechanisms of IRF5 action in inflammatory responses

(2018) Tariq E. Khoyratty et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IRF5-mediated immune responses and its implications in immunological disorders

(2018) Ashwinder Kaur et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Critical role of ROCK2 activity in facilitating mucosal CD4 + T cell activation in inflammatory bowel disease

(2018) Wenjing Yang et al.   JOURNAL OF AUTOIMMUNITY

Critical Role of CD6highCD4+ T Cells in Driving Th1/Th17 Cell Immune Responses and Mucosal Inflammation in IBD

(2018) Caiyun Ma et al.   Journal of Crohns & Colitis

The Pathogenesis of Extraintestinal Manifestations: Implications for IBD research, diagnosis and therapy

(2018) C R H Hedin et al.   Journal of Crohns & Colitis

Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease

(2018) Cui Zhang et al.   MEDIATORS OF INFLAMMATION

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

(2017) Gilaad G. Kaplan et al.   GASTROENTEROLOGY

CD177+neutrophils as functionally activated neutrophils negatively regulate IBD

(2017) Guangxi Zhou et al.   GUT

Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting T H 1/T H 17 cell differentiation in patients with inflammatory bowel diseases

(2017) Guangxi Zhou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

(2017) Leah Cushing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential roles of neutrophils in regulating intestinal mucosal inflammation of inflammatory bowel disease

(2017) Guang Xi Zhou et al.   Journal of Digestive Diseases

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

(2017) Lauren A Peters et al.   NATURE GENETICS

Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease

(2016) Alon D. Levin et al.   Journal of Crohns & Colitis

Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease

(2016) Guangxi Zhou et al.   MEDIATORS OF INFLAMMATION

A critical role for IRF5 in regulating allergic airway inflammation

(2016) A J Byrne et al.   Mucosal Immunology

CD99 refers to the activity of inflammatory bowel disease

(2016) Guangxi Zhou et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease

(2016) Hayley L. Eames et al.   Translational Research

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation

(2016) Matija Hedl et al.   Cell Reports

New insights into immune mechanisms underlying autoimmune diseases of the gastrointestinal tract

(2015) Antonio Di Sabatino et al.   AUTOIMMUNITY REVIEWS

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis

(2015) Ryosuke Saigusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF5 controls both acute and chronic inflammation

(2015) Miriam Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis

(2015) Italia Loddo et al.   Frontiers in Immunology

miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD

(2014) Wei Wu et al.   GUT

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

(2014) Sarah Kim et al.   Nature Communications

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages

(2014) David G. Saliba et al.   Cell Reports

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

(2013) Holm H Uhlig   GUT

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

(2013) M Zaeem Cader et al.   GUT

A two-marker haplotype in the IRF5 gene is associated with inflammatory bowel disease in a North American cohort

(2012) G Gathungu et al.   GENES AND IMMUNITY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

The CGGGG insertion/deletion polymorphism of theIRF5promoter is a strong risk factor for primary Sjögren's syndrome

(2009) Corinne Miceli-Richard et al.   ARTHRITIS AND RHEUMATISM

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis

(2008) Teruji Totsuka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY