Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing

Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns

(2016) Steven A. Castleberry et al.   BIOMATERIALS

Disturbed hypoxic responses as a pathogenic mechanism of diabetic foot ulcers

(2016) Sergiu-Bogdan Catrina et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

(2016) Mun Chiang Chan et al.   MOLECULAR ASPECTS OF MEDICINE

Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound

(2016) Hao Chen et al.   Advanced Healthcare Materials

Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo

(2015) Steven A. Castleberry et al.   ADVANCED MATERIALS

Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold

(2015) Elizabeth R. Lorden et al.   BIOMATERIALS

A transient cell-shielding method for viable MSC delivery within hydrophobic scaffolds polymerized in situ

(2015) Ruijing Guo et al.   BIOMATERIALS

Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers

(2015) Martina Miteva et al.   BIOMATERIALS

Conjugation of palmitic acid improves potency and longevity of siRNA delivered via endosomolytic polymer nanoparticles

(2015) Samantha M. Sarett et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Injected biodegradable polyurethane scaffolds support tissue infiltration and delay wound contraction in a porcine excisional model

(2015) Elizabeth J. Adolph et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Technologies for controlled, local delivery of siRNA

(2015) Samantha M. Sarett et al.   JOURNAL OF CONTROLLED RELEASE

Acellular dermal matrix-based gene therapy augments graft incorporation

(2015) Meredith T. Vandegrift et al.   JOURNAL OF SURGICAL RESEARCH

Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications

(2015) So Kim et al.   MOLECULES

Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo

(2015) Benjamin D. Almquist et al.   Advanced Healthcare Materials

A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species

(2014) John R. Martin et al.   BIOMATERIALS

Prevalence and Incidence Trends for Diagnosed Diabetes Among Adults Aged 20 to 79 Years, United States, 1980-2012

(2014) Linda S. Geiss et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury

(2014) Andrew S. Zimmermann et al.   PLoS One

Enhanced performance of plasmid DNA polyplexes stabilized by a combination of core hydrophobicity and surface PEGylation

(2014) Elizabeth J. Adolph et al.   Journal of Materials Chemistry B

Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo

(2013) Christopher E. Nelson et al.   ADVANCED MATERIALS

A Reactive Oxygen Species (ROS)-Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells

(2013) Min Suk Shim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors

(2013) Yevgeny Brudno et al.   BIOMATERIALS

Epidermal Deletion of HIF-2α Stimulates Wound Closure

(2013) Andrew S. Cowburn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Loss of Epithelial Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Accelerates Skin Wound Healing in Mice

(2013) Joanna Kalucka et al.   MOLECULAR AND CELLULAR BIOLOGY

Wound Healing Improvement with PHD-2 Silenced Fibroblasts in Diabetic Mice

(2013) Xiongliang Zhang et al.   PLoS One

Sustained local delivery of siRNA from an injectable scaffold

(2011) Christopher E. Nelson et al.   BIOMATERIALS

Localized, Targeted, and Sustained siRNA Delivery

(2011) Melissa D. Krebs et al.   CHEMISTRY-A EUROPEAN JOURNAL

Injectable polyurethane composite scaffolds delay wound contraction and support cellular infiltration and remodeling in rat excisional wounds

(2011) Elizabeth J. Adolph et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Topical prolyl hydroxylase domain-2 silencing improves diabetic murine wound closure

(2011) Meredith Wetterau et al.   WOUND REPAIR AND REGENERATION

pH-Responsive Polymeric Micelle Carriers for siRNA Drugs

(2010) A. J. Convertine et al.   BIOMACROMOLECULES

Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds

(2010) Andrea E. Hafeman et al.   BIOMATERIALS

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Improved diabetic wound healing through topical silencing of p53 is associated with augmented vasculogenic mediators

(2010) Phuong D. Nguyen et al.   WOUND REPAIR AND REGENERATION

The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds

(2009) Bing Li et al.   BIOMATERIALS

Local Delivery of Tobramycin from Injectable Biodegradable Polyurethane Scaffolds

(2009) Andrea E. Hafeman et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

BARRIERS TO SUCCESSFUL DELIVERY OF SHORT INTERFERING RNA AFTER SYSTEMIC ADMINISTRATION

(2008) Paul J White   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Development of a novel endosomolytic diblock copolymer for siRNA delivery

(2008) Anthony J. Convertine et al.   JOURNAL OF CONTROLLED RELEASE

Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

(2008) Andrea E. Hafeman et al.   PHARMACEUTICAL RESEARCH

Stabilization of HIF-1  is critical to improve wound healing in diabetic mice

(2008) I. R. Botusan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD