Advances and challenges in targeting IRF5, a key regulator of inflammation

Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability

(2018) Justyna Korczeniewska et al.   MOLECULAR AND CELLULAR BIOLOGY

An AAAG-Rich Oligodeoxynucleotide Rescues Mice from Bacterial Septic Peritonitis by Interfering Interferon Regulatory Factor 5

(2017) Shuang Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

(2017) Leah Cushing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

(2017) Amy T. Y. Yeung et al.   Nature Communications

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

(2016) Maggie L. Bobbin et al.   Annual Review of Pharmacology and Toxicology

Peptide-based inhibitors of protein–protein interactions

(2016) Paulina Wójcik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity

(2016) Tatsuma Ban et al.   IMMUNITY

A critical role for IRF5 in regulating allergic airway inflammation

(2016) A J Byrne et al.   Mucosal Immunology

CRISPR gene-editing tested in a person for the first time

(2016) David Cyranoski   NATURE

An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice

(2016) Dorothee Weihrauch et al.   PLoS One

Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease

(2016) Hayley L. Eames et al.   Translational Research

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation

(2016) Matija Hedl et al.   Cell Reports

Epstein Barr Virus and Mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of MS patients

(2016) Giuseppe Mameli et al.   Scientific Reports

Selection by phage display of nanobodies directed against hypoxia inducible factor-1α (HIF-1α)

(2015) Min Li et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial

(2015) Eveline P. van Poelgeest et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

TLR8 SensesStaphylococcus aureusRNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

(2015) Bjarte Bergstrøm et al.   JOURNAL OF IMMUNOLOGY

Activation and Function of Interferon Regulatory Factor 5

(2015) Grigory Ryzhakov et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

(2015) Elise Dalmas et al.   NATURE MEDICINE

Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis

(2015) Ryosuke Saigusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF5 controls both acute and chronic inflammation

(2015) Miriam Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model

(2015) Pierre Duffau et al.   Arthritis & Rheumatology

Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients

(2014) Meike H. van der Ree et al.   ANTIVIRAL RESEARCH

Human interferon regulatory factor 5 homologous epitopes of Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis induce a specific humoral and cellular immune response in multiple sclerosis patients

(2014) Davide Cossu et al.   Multiple Sclerosis Journal

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

(2014) Jonas Bethuyne et al.   NUCLEIC ACIDS RESEARCH

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

(2014) Elisa Lazzari et al.   PLoS One

IKKβ is an IRF5 kinase that instigates inflammation

(2014) Junyao Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

(2014) Marta Lopez-Pelaez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages

(2014) David G. Saliba et al.   Cell Reports

Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors

(2013) Woondong Jeong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting transcription factors

(2013) Jennifer E. Yeh et al.   CURRENT OPINION IN ONCOLOGY

Protein–protein interactions as druggable targets: recent technological advances

(2013) Alicia P Higueruelo et al.   CURRENT OPINION IN PHARMACOLOGY

Interferon-β Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C. albicans

(2013) Carlos del Fresno et al.   IMMUNITY

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

(2013) Gabriel Courties et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

IRF5 Is a Specific Marker of Inflammatory MacrophagesIn Vivo

(2013) Miriam Weiss et al.   MEDIATORS OF INFLAMMATION

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE

(2013) Rivka C. Stone et al.   PLoS One

C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells

(2012) Johan Bäcklund et al.   ANNALS OF THE RHEUMATIC DISEASES

Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching

(2012) Di Feng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

KAP1/TRIM28: An inhibitor of IRF5 function in inflammatory macrophages

(2012) H.L. Eames et al.   IMMUNOBIOLOGY

Activation of Interferon Regulatory Factor 5 by Site Specific Phosphorylation

(2012) Hui-Chen Chang Foreman et al.   PLoS One

4F Decreases IRF5 Expression and Activation in Hearts of Tight Skin Mice

(2012) Hao Xu et al.   PLoS One

Myeloid Differentiation Factor-2 Interacts with Lyn Kinase and Is Tyrosine Phosphorylated Following Lipopolysaccharide-Induced Activation of the TLR4 Signaling Pathway

(2011) Pearl Gray et al.   JOURNAL OF IMMUNOLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection

(2011) Andrea Paun et al.   PLoS Pathogens

IRF5 is required for late-phase TNF secretion by human dendritic cells

(2010) T. Krausgruber et al.   BLOOD

Intracellular Activation of Interferon Regulatory Factor-1 by Nanobodies to the Multifunctional (Mf1) Domain

(2010) Angeli Möller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Requirement of Histone Acetylase and Deacetylase Activities for IRF5-Mediated Proinflammatory Cytokine Expression

(2010) D. Feng et al.   JOURNAL OF IMMUNOLOGY

Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

(2010) Erica Marchlik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus

(2010) D. A. Savitsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation

(2009) Magdalena Koziczak-Holbro et al.   ARTHRITIS AND RHEUMATISM

IKKα negatively regulates IRF-5 function in a MyD88–TRAF6 pathway

(2009) Mumtaz Yaseen Balkhi et al.   CELLULAR SIGNALLING

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

(2008) Rebeca Dieguez-Gonzalez et al.   ARTHRITIS AND RHEUMATISM

Functional Characterization of Murine Interferon Regulatory Factor 5 (IRF-5) and Its Role in the Innate Antiviral Response

(2008) Andrea Paun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination

(2008) M. Y. Balkhi et al.   MOLECULAR AND CELLULAR BIOLOGY

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

(2008) Weijun Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY