Nanoparticle-Delivered IRF5 siRNA Facilitates M1 to M2 Transition, Reduces Demyelination and Neurofilament Loss, and Promotes Functional Recovery After Spinal Cord Injury in Mice

Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury

(2016) Simonetta Papa et al.   BIOMATERIALS

Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury

(2015) Shan-Feng Ma et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury

(2015) Guzal Khayrullina et al.   Journal of Neuroinflammation

Macrophage and microglial plasticity in the injured spinal cord

(2015) S. David et al.   NEUROSCIENCE

CCR5 Blockade Promotes M2 Macrophage Activation and Improves Locomotor Recovery After Spinal Cord Injury in Mice

(2014) Fengtao Li et al.   INFLAMMATION

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

(2014) Hans G Novrup et al.   Journal of Neuroinflammation

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

The Therapeutic Role of Interleukin-10 after Spinal Cord Injury

(2013) Colton D. Thompson et al.   JOURNAL OF NEUROTRAUMA

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

(2013) Gabriel Courties et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

IRF5 Is a Specific Marker of Inflammatory MacrophagesIn Vivo

(2013) Miriam Weiss et al.   MEDIATORS OF INFLAMMATION

Attacking the genome: emerging siRNA nanocarriers from concept to clinic

(2012) Christopher Alabi et al.   CURRENT OPINION IN PHARMACOLOGY

Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

(2012) Alexander Rodriguez Guerrero et al.   Journal of Neuroinflammation

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

(2012) Tatiana I Novobrantseva et al.   Molecular Therapy-Nucleic Acids

Multipotent Adult Progenitor Cells Prevent Macrophage-Mediated Axonal Dieback and Promote Regrowth after Spinal Cord Injury

(2011) S. A. Busch et al.   JOURNAL OF NEUROSCIENCE

Progress Toward In Vivo Use of siRNAs-II

(2011) Garrett R Rettig et al.   MOLECULAR THERAPY

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

(2011) Mark E. Lobatto et al.   NATURE REVIEWS DRUG DISCOVERY

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Tumor Necrosis Factor-α Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury

(2011) Ke-Bing Chen et al.   SPINE

“Tissue-repairing” blood-derived macrophages are essential for healing of the injured spinal cord: From skin-activated macrophages to infiltrating blood-derived cells?

(2010) Michal Schwartz   BRAIN BEHAVIOR AND IMMUNITY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Myelin Activates FAK/Akt/NF-κB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine System

(2010) Xin Sun et al.   PLoS One

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidance Molecules in Axon Regeneration

(2010) R. J. Giger et al.   Cold Spring Harbor Perspectives in Biology

Macrophages and Inflammatory Mediators in Chemical Toxicity: A Battle of Forces

(2009) Debra L. Laskin   CHEMICAL RESEARCH IN TOXICOLOGY

Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity

(2009) J. C. Gensel et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions

(2008) K. P. Horn et al.   JOURNAL OF NEUROSCIENCE

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE