Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury

(2012) John R. Klune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors

(2012) A. M. Becker et al.   BLOOD

KAP1/TRIM28: An inhibitor of IRF5 function in inflammatory macrophages

(2012) H.L. Eames et al.   IMMUNOBIOLOGY

CSF-1 signaling mediates recovery from acute kidney injury

(2012) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation

(2012) T.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

IRF5 Risk Polymorphisms Contribute to Interindividual Variance in Pattern Recognition Receptor-Mediated Cytokine Secretion in Human Monocyte-Derived Cells

(2012) M. Hedl et al.   JOURNAL OF IMMUNOLOGY

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

(2011) Rivka C. Stone et al.   ARTHRITIS AND RHEUMATISM

Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway

(2011) Leonid Tarassishin et al.   Journal of Neuroinflammation

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis

(2011) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection

(2011) Andrea Paun et al.   PLoS Pathogens

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Genetic variants and disease-associated factors contribute to enhanced IRF-5 expression in blood cells of systemic lupus erythematosus patients

(2010) Di Feng et al.   ARTHRITIS AND RHEUMATISM

Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming

(2010) Carol El Chartouni et al.   IMMUNOBIOLOGY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury

(2010) M.-G. Kim et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus

(2010) D. A. Savitsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

Chemokine receptor Ccr5 deficiency induces alternative macrophage activation and improves long-term renal allograft outcome

(2009) Stefan Dehmel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFN Regulatory Factor 4 Regulates the Expression of a Subset of Th2 Cytokines

(2009) A.-N. N. Ahyi et al.   JOURNAL OF IMMUNOLOGY

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

(2009) Andrew J. Fleetwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IRF-1 Promotes Inflammation Early after Ischemic Acute Kidney Injury

(2009) Y. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Regulation of IRF2 transcriptional activity by its sumoylation

(2008) Ke-Jun Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interferon regulatory factor family of transcription factors and regulation of oncogenesis

(2008) Akinori Takaoka et al.   CANCER SCIENCE

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

(2008) Min Zhang et al.   CELL RESEARCH

Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments

(2008) Chen-Feng Qi et al.   IMMUNOLOGIC RESEARCH

IRF8 regulates myeloid and B lymphoid lineage diversification

(2008) Hongsheng Wang et al.   IMMUNOLOGIC RESEARCH

First responders: understanding monocyte-lineage traffic in the acutely injured kidney

(2008) Sundararaman Swaminathan et al.   KIDNEY INTERNATIONAL