Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

Macrophages as APC and the Dendritic Cell Myth

(2014) D. A. Hume   JOURNAL OF IMMUNOLOGY

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

Increased Serum Enzyme Levels Associated with Kupffer Cell Reduction with No Signs of Hepatic or Skeletal Muscle Injury

(2011) Zaher A. Radi et al.   AMERICAN JOURNAL OF PATHOLOGY

Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

(2011) Maliha A. Alikhan et al.   AMERICAN JOURNAL OF PATHOLOGY

Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing

(2011) Y. Okuno et al.   BLOOD

c-FMS inhibitors: a patent review

(2011) Christopher J Burns et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

(2011) Kylie A Alexander et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

(2011) Daigo Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth

(2011) Soraya Zorro Manrique et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1

(2011) Elisa Tagliani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages at the Fetal-Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10

(2011) J. Svensson et al.   JOURNAL OF IMMUNOLOGY

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

(2011) Lynsey Fairbairn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat

(2011) Yingjie Han et al.   LABORATORY INVESTIGATION

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation

(2010) T Chihara et al.   CELL DEATH AND DIFFERENTIATION

Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood

(2010) Hiroyuki Eda et al.   CYTOKINE

Association between colony-stimulating factor 1 receptor gene polymorphisms and asthma risk

(2010) Eun Kyong Shin et al.   HUMAN GENETICS

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations

(2010) Neil A. Mabbott et al.   IMMUNOBIOLOGY

Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1 ), interleukin-34 (IL-34 ), and CSF-1 receptor genes and gene products

(2010) Valerie Garceau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice

(2010) Dmitry A. Ovchinnikov et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CSF-1, IGF-1, and the control of postnatal growth and development

(2010) Deborah J. Gow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

(2010) D. A. Hume   JOURNAL OF LEUKOCYTE BIOLOGY

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

(2010) Omar M E Albagha et al.   NATURE GENETICS

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis

(2010) Ricardo T Paniagua et al.   ARTHRITIS RESEARCH & THERAPY

Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response

(2009) Jane E. Mooney et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

Powerful beneficial effects of macrophage colony-stimulating factor on  -amyloid deposition and cognitive impairment in Alzheimer's disease

(2009) V. Boissonneault et al.   BRAIN

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

(2009) A. K. H. Lim et al.   DIABETOLOGIA

Administration of high-dose macrophage colony-stimulating factor increases bone turnover and trabecular volume fraction

(2009) Shane A. Lloyd et al.   JOURNAL OF BONE AND MINERAL METABOLISM

CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice

(2009) Julia Menke et al.   JOURNAL OF CLINICAL INVESTIGATION

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CX3CR1+CD115+CD135+common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

(2009) Cedric Auffray et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Liver Regeneration is Impaired in Macrophage Colony Stimulating Factor Deficient Mice After Partial Hepatectomy: The Role of M-CSF-Induced Macrophages

(2009) Hidetake Amemiya et al.   JOURNAL OF SURGICAL RESEARCH

Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis

(2009) J. Menke et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

(2009) C. L. Manthey et al.   MOLECULAR CANCER THERAPEUTICS

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors

(2008) Mark J. Wall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis

(2008) M SEGAWA et al.   EXPERIMENTAL CELL RESEARCH

Clinical use of colony-stimulating factor-1 in ovulation induction for poor responders

(2008) Akihisa Takasaki et al.   FERTILITY AND STERILITY

Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses

(2008) Frederic Geissmann et al.   IMMUNOLOGY AND CELL BIOLOGY

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

(2008) K. M. Irvine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis

(2008) Yasunori Uemura et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of the cFMS Kinase Inhibitor 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in Normal and Arthritic Rats

(2008) J. G. Conway et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Differentiation and heterogeneity in the mononuclear phagocyte system

(2008) D A Hume   Mucosal Immunology

Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases

(2008) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE

Antigen presentation by monocytes and monocyte-derived cells

(2007) Gwendalyn J Randolph et al.   CURRENT OPINION IN IMMUNOLOGY

The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model

(2007) Hiroaki Ohno et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

(2007) Constanze Bonifer   Frontiers in Bioscience-Landmark

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark