IRF7: activation, regulation, modification and function

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

TLR4 Ligands Induce IFN-  Production by Mouse Conventional Dendritic Cells and Human Monocytes after IFN-  Priming

(2014) C. Richez et al.   JOURNAL OF IMMUNOLOGY

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-α activity in lupus patients

(2010) Rafah Salloum et al.   ARTHRITIS AND RHEUMATISM

Association of a functional IRF7 variant with systemic lupus erythematosus

(2010) Qiong Fu et al.   ARTHRITIS AND RHEUMATISM

Aberrant expression of interferon regulatory factor 3 in human lung cancer

(2010) Takayuki Tokunaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of immunity and oncogenesis by the IRF transcription factor family

(2010) David Savitsky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Viral apoptosis is induced by IRF-3-mediated activation of Bax

(2010) Saurabh Chattopadhyay et al.   EMBO JOURNAL

The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

(2010) Yanxing Yu et al.   IMMUNITY

Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8

(2010) T. Zhang et al.   JOURNAL OF GENERAL VIROLOGY

The A20 Deubiquitinase Activity Negatively Regulates LMP1 Activation of IRF7

(2010) S. Ning et al.   JOURNAL OF VIROLOGY

Expression profiles of adult T-cell leukemia–lymphoma and associations with clinical responses to zidovudine and interferon α

(2010) Ash A. Alizadeh et al.   LEUKEMIA & LYMPHOMA

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

(2010) Matthias Heinig et al.   NATURE

The many paths to asthma: phenotype shaped by innate and adaptive immunity

(2010) Hye Young Kim et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Dual Functions of Interferon Regulatory Factors 7C in Epstein-Barr Virus–Mediated Transformation of Human B Lymphocytes

(2010) Yong Zhao et al.   PLoS One

Antagonism of Host Antiviral Responses by Kaposi's Sarcoma-Associated Herpesvirus Tegument Protein ORF45

(2010) Fan Xiu Zhu et al.   PLoS One

Murine Toll-Like Receptor 2 Activation Induces Type I Interferon Responses from Endolysosomal Compartments

(2010) Nicole Dietrich et al.   PLoS One

Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

(2010) Rowan Higgs et al.   PLoS One

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

(2010) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of IRF-5 in regulation of B-cell differentiation

(2010) C. Lien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein–Barr virus BRLF1 inhibits transcription of IRF3 and IRF7 and suppresses induction of interferon-β

(2010) Gretchen L. Bentz et al.   VIROLOGY

SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2

(2009) Sun-Mi Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN

(2009) J. Di Domizio et al.   BLOOD

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

MicroRNA Control in the Immune System: Basic Principles

(2009) Changchun Xiao et al.   CELL

Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins

(2009) Tetsuo Tsuchida et al.   CELL RESEARCH

Structural insights into interferon regulatory factor activation

(2009) Weijun Chen et al.   CELLULAR SIGNALLING

IRF4: Immunity. Malignancy! Therapy?

(2009) A. L. Shaffer et al.   CLINICAL CANCER RESEARCH

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

The Kaposi's Sarcoma-associated Herpesvirus-encoded vIRF-3 Inhibits Cellular IRF-5

(2009) Effi Wies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor

(2009) N. Buettner et al.   JOURNAL OF GENERAL VIROLOGY

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Viral Interferon Regulatory Factors

(2009) Hye-Ra Lee et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon Regulatory Factors in Hematopoietic Cell Differentiation and Immune Regulation

(2009) Angela Battistini   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The ambiguous role of interferon regulatory factor-1 (IRF-1) immunoexpression in myelodysplastic syndrome

(2009) Ronald Feitosa Pinheiro et al.   LEUKEMIA RESEARCH

Good and bad IRF-1: Role in tumor suppression versus autoimmune disease

(2009) Dan A. Liebermann et al.   LEUKEMIA RESEARCH

Differential Regulation of Human Interferon A Gene Expression by Interferon Regulatory Factors 3 and 7

(2009) P. Genin et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamic Evolution of Immune System Regulators: The History of the Interferon Regulatory Factor Family

(2009) J. Nehyba et al.   MOLECULAR BIOLOGY AND EVOLUTION

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

(2009) Wenwen Zeng et al.   MOLECULAR CELL

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA

(2009) Hiroyasu Konno et al.   PLoS One

Functional Analysis of a Dominant Negative Mutation of Interferon Regulatory Factor 5

(2009) Long Yang et al.   PLoS One

Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages

(2009) Yunlong Huang et al.   PLoS One

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA

(2009) M. K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

RIG-I-like receptors: Sensing and responding to RNA virus infection

(2009) Peyman Nakhaei et al.   SEMINARS IN IMMUNOLOGY

Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery

(2009) Tsung-Hsien Chang et al.   PLoS Pathogens

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention

(2008) Wan-Uk Kim et al.   AUTOIMMUNITY REVIEWS

Regulation of IRF2 transcriptional activity by its sumoylation

(2008) Ke-Jun Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Latent membrane protein-1 of Epstein-Barr virus induces the expression of B-cell integration cluster, a precursor form of microRNA-155, in B lymphoma cell lines

(2008) Nur Rahadiani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2

(2008) Susanne Pettersson et al.   BIOCHEMICAL JOURNAL

Targeting IRFs by ubiquitination: regulating antiviral responses

(2008) Rowan Higgs et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

HSV ICP0 recruits USP7 to modulate TLR-mediated innate response

(2008) S. Daubeuf et al.   BLOOD

Interferon regulatory factor family of transcription factors and regulation of oncogenesis

(2008) Akinori Takaoka et al.   CANCER SCIENCE

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

(2008) Min Zhang et al.   CELL RESEARCH

MicroRNAs in normal and malignant hematopoiesis

(2008) Ramiro Garzon et al.   CURRENT OPINION IN HEMATOLOGY

IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation

(2008) Yasutaka Okabe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Interferons: Signaling, antiviral and viral evasion

(2008) Cláudio A. Bonjardim et al.   IMMUNOLOGY LETTERS

Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression

(2008) Toru Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway

(2008) Guodong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon Regulatory Factor 4 Is Involved in Epstein-Barr Virus-Mediated Transformation of Human B Lymphocytes

(2008) D. Xu et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus LF2: an Antagonist to Type I Interferon

(2008) L. Wu et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway

(2008) J.-T. Wang et al.   JOURNAL OF VIROLOGY

MicroRNA-155 Is an Epstein-Barr Virus-Induced Gene That Modulates Epstein-Barr Virus-Regulated Gene Expression Pathways

(2008) Q. Yin et al.   JOURNAL OF VIROLOGY

TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1

(2008) S. Ning et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Telomerase Activity by Interferon Regulatory Factors 4 and 8 in Immune Cells

(2008) R. Hrdlickova et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination

(2008) M. Y. Balkhi et al.   MOLECULAR AND CELLULAR BIOLOGY

Interferon Regulatory Factor 6 Promotes Cell Cycle Arrest and Is Regulated by the Proteasome in a Cell Cycle-Dependent Manner

(2008) C. M. Bailey et al.   MOLECULAR AND CELLULAR BIOLOGY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Interferon Regulatory Factors IRF5 and IRF7 Inhibit Growth and Induce Senescence in Immortal Li-Fraumeni Fibroblasts

(2008) Q. Li et al.   MOLECULAR CANCER RESEARCH

Cell biology: SUMO

(2008) Erik Meulmeester et al.   NATURE

IRF4 addiction in multiple myeloma

(2008) Arthur L. Shaffer et al.   NATURE

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Immunology in China: the past, present and future

(2008) Xuetao Cao   NATURE IMMUNOLOGY

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

(2008) Weijun Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epstein–Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway

(2008) Graziana Gatto et al.   NUCLEIC ACIDS RESEARCH

IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3

(2008) Y.-J. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis

(2008) A. Couzinet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis

(2008) Chengyu Liang et al.   SEMINARS IN CANCER BIOLOGY

Conserved herpesvirus protein kinases

(2007) Edward Gershburg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY

Differential regulation of IKKα-mediated activation of IRF3/7 by NIK

(2007) Rui-Peng Wang et al.   MOLECULAR IMMUNOLOGY