Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Circular RNA circ_IRAK3 contributes to tumor growth through upregulating KIF2A via adsorbing miR-603 in breast cancer

(2022) Fang Wang et al.   Cancer Cell International

CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein

(2022) Chi Hin Wong et al.   Molecular Cancer

Circ_0003221 Downregulation Restrains Cervical Cancer Cell Growth, Metastasis and Angiogenesis by Governing the miR-139-3p/S100A14 Pathway

(2022) Xiaoli Chi et al.   Reproductive Sciences

Accentuating CircRNA-miRNA-Transcription Factors Axis: A Conundrum in Cancer Research

(2022) Deepti Singh et al.   Frontiers in Pharmacology

Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis

(2022) Yan-Yu Peng et al.   Bioengineered

Circular RNA circ_0000518 promotes breast cancer progression through the microRNA-1225-3p/SRY-box transcription factor 4 pathway

(2022) Kang Shujuan et al.   Bioengineered

CircRNA SOD2 motivates non-small cell lungs cancer advancement with EMT via acting as microRNA-2355-5p’s competing endogenous RNA to mediate calmodulin regulated spectrin associated proteins-2

(2022) Changsheng Lv et al.   Bioengineered

Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis

(2022) Aliaksandr A. Yarmishyn et al.   Cancers

Hsa_circ_0023984 Regulates Cell Proliferation, Migration, and Invasion in Esophageal Squamous Cancer via Regulating miR-1294/PI3K/Akt/c-Myc Pathway

(2022) Wenchang Liang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR‐361‐3p/TGFB1

(2022) Ying Zhou et al.   CANCER SCIENCE

Circular RNA circ_0006089 regulates the IGF1R expression by targeting miR-143-3p to promote gastric cancer proliferation, migration and invasion

(2022) Xian Wang et al.   CELL CYCLE

Circ_0085315 promotes cell proliferation, invasion, and migration in colon cancer through miR-1200/MAP3K1 signaling pathway

(2022) Yuan Luo et al.   CELL CYCLE

circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR‐2467‐3p/E2F6

(2022) Shu‐Lan Gao et al.   ENVIRONMENTAL TOXICOLOGY

Tumor Microenvironment of Hepatocellular Carcinoma: Challenges and Opportunities for New Treatment Options

(2022) Zuzanna Sas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CircRNA_0008194 functions as a ceRNA to promote invasion of hepatocellular carcinoma via inhibiting miR‐190a/AHNAK signaling pathway

(2022) Wei Liu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Hsa_circ_0006732 regulates colorectal cancer cell proliferation, invasion and EMT by miR-127-5p/RAB3D axis

(2022) Tao Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Circular RNA circ_0051620 sponges miR-338–3p and regulates ADAM17 to promote the gastric cancer progression

(2022) Mandana AmeliMojarad et al.   PATHOLOGY RESEARCH AND PRACTICE

Circ_CDR1as: a circular RNA with roles in the carcinogenesis

(2022) Soudeh Ghafouri-Fard et al.   PATHOLOGY RESEARCH AND PRACTICE

CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis

(2022) Lunhua Shen et al.   Reproductive Sciences

circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway

(2022) Huan Song et al.   Cell Death & Disease

Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR ‐223‐3p

(2022) Xiuling Tian et al.   Thoracic Cancer

Circ_0001273 downregulation inhibits the growth, migration and glutamine metabolism of esophageal cancer cells via targeting the miR ‐622/ SLC1A5 signaling axis

(2022) Bomeng Wu et al.   Thoracic Cancer

The Interaction Between Non-Coding RNAs and Calcium Binding Proteins

(2022) Soudeh Ghafouri-Fard et al.   Frontiers in Oncology

Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis

(2022) Quanbin Zha et al.   Cell Death Discovery

Diabetes and Pancreatic Cancer—A Dangerous Liaison Relying on Carbonyl Stress

(2021) Stefano Menini et al.   Cancers

circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis

(2021) Xing Zhang et al.   BMC Molecular and Cell Biology

CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

(2021) Peng Shen et al.   Molecular Cancer

CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway

(2021) Xinxing Wang et al.   Aging-US

mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity

(2021) Li Guo et al.   BRIEFINGS IN BIOINFORMATICS

Circular RNA hsa_circ_0003288 induces EMT and invasion by regulating hsa_circ_0003288/miR-145/PD-L1 axis in hepatocellular carcinoma

(2021) Guili Xu et al.   Cancer Cell International

Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases

(2021) Chisato Kinoshita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Circular RNA CircNFATC3 in Cancer Cells Alters Proliferation, Migration, and Oxidative Phosphorylation

(2021) Thasni Karedath et al.   Frontiers in Cell and Developmental Biology

A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals

(2021) Ji Yeon Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

circRNA RPPH1 Facilitates the Aggravation of Breast Cancer Development by Regulating miR-542-3p/ARHGAP1 Pathway

(2021) Liqiang Qi et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers

(2021) Pranavi Garlapati et al.   Cancer Cell International

CircRNA_100290 promotes GC cell proliferation and invasion via the miR-29b-3p/ITGA11 axis and is regulated by EIF4A3

(2021) Gang Wang et al.   Cancer Cell International

The effective function of circular RNA in colorectal cancer

(2021) Mandana Ameli-Mojarad et al.   Cancer Cell International

Could the Epigenetics of Eosinophils in Asthma and Allergy Solve Parts of the Puzzle?

(2021) Émile Bélanger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis

(2021) Yaxin Guo et al.   Molecular Cancer

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling

(2021) Yingru Xu et al.   Molecular Cancer

CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p

(2021) ZhenYu Shen et al.   OncoTargets and Therapy

Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression

(2021) Gang Ma et al.   Cell Death & Disease

Hsa_circ_0026628 promotes the development of colorectal cancer by targeting SP1 to activate the Wnt/β-catenin pathway

(2021) Xuexiu Zhang et al.   Cell Death & Disease

circ‑ACACA promotes proliferation, invasion, migration and glycolysis of cervical cancer cells by targeting the miR‑582‑5p/ERO1A signaling axis

(2021) Dandan Huang et al.   Oncology Letters

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

(2021) Maria Papatsirou et al.   Cancers

Insights into the Evolving Roles of Circular RNAs in Cancer

(2021) Katherine Louise Harper et al.   Cancers

Overexpression of Circular RNA circ_0013587 Reverses Erlotinib Resistance in Pancreatic Cancer Cells Through Regulating the miR-1227/E-Cadherin Pathway

(2021) Huiting Xu et al.   Frontiers in Oncology

Splice and Dice: Intronic microRNAs, Splicing and Cancer

(2021) Alex C. H. Wong et al.   Biomedicines

CircRNAs: Insights into Gastric Cancer

(2021) Sanjana Rajgopal et al.   Gastrointestinal Tumors

Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease

(2021) Debora Traversa et al.   BRITISH JOURNAL OF CANCER

ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β

(2021) Lingjiao Meng et al.   CANCER LETTERS

Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1α/VEGFA pathway

(2021) Yu Du et al.   CANCER LETTERS

Circ-CSPP1 knockdown suppresses hepatocellular carcinoma progression through miR-493-5p releasing-mediated HMGB1 downregulation

(2021) Ganghua Yang et al.   CELLULAR SIGNALLING

Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator

(2021) Farzaneh Darbeheshti et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Circular RNA hsa_circ_0000730 restrains cell proliferation, migration, and invasion in cervical cancer through miR ‐942‐5p/ PTEN axis

(2021) Dan‐Dan Yuan et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

CircRNA Circ-CCND1 Aggravates Hepatocellular Carcinoma Tumorigenesis by Regulating the miR-497-5p/HMGA2 Axis

(2021) Sheng Zheng et al.   MOLECULAR BIOTECHNOLOGY

Circ_0092367 Inhibits EMT and Gemcitabine Resistance in Pancreatic Cancer via Regulating the miR-1206/ESRP1 Axis

(2021) Shuo Yu et al.   Genes

Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma

(2021) Haiping Zhang et al.   Bioengineered

Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function

(2021) Mohammad Taheri et al.   Frontiers in Immunology

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019

(2021) et al.   JAMA Oncology

Emerging Role of Extracellular Vesicles and Cellular Communication in Metastasis

(2021) Aisling Forder et al.   Cells

Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27

(2021) Yantao Mao et al.   Biomedical Journal

Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas

(2021) Eleftheria Lakiotaki et al.   Biomedicines

Coupling miR/isomiR and mRNA Expression Signatures Unveils New Molecular Layers of Endometrial Receptivity

(2021) Maria Nikolova et al.   Life-Basel

Correction for: Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma

(2020) Zihao Pan et al.   Aging-US

CircRNA_0005075 suppresses carcinogenesis via regulating miR‐431/p53/epithelial‐mesenchymal transition axis in gastric cancer

(2020) Jiaming Wu et al.   CELL BIOCHEMISTRY AND FUNCTION

Circular RNA hsa_circ_0061825 (circ‐TFF1) contributes to breast cancer progression through targeting miR‐326/TFF1 signalling

(2020) Gaofeng Pan et al.   CELL PROLIFERATION

Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells

(2020) Jin Hua He et al.   Frontiers in Genetics

Epidemiology of Hepatocellular Carcinoma

(2020) Katherine A. McGlynn et al.   HEPATOLOGY

Hsa_circ_0043265 Suppresses Proliferation, Metastasis, EMT and Promotes Apoptosis in Non-Small Cell Lung Cancer Through miR-25-3p/FOXP2 Pathway

(2020) Tiejun Ren et al.   OncoTargets and Therapy

Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis

(2020) Jianjun Liu et al.   OncoTargets and Therapy

Rewired functional regulatory networks among miRNA isoforms (isomiRs) from let-7 and miR-10 gene families in cancer

(2020) Tingming Liang et al.   Computational and Structural Biotechnology Journal

Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway

(2020) Xinglong Dai et al.   CLINICAL SCIENCE

Circular RNA 000554 represses epithelial‐mesenchymal transition in breast cancer by regulating microRNA‐182/ZFP36 axis

(2020) Yan Mao et al.   FASEB JOURNAL

Genetic Markers in Lung Cancer Diagnosis: A Review

(2020) Katarzyna Wadowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/β-catenin pathway

(2020) Min Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

CircFNDC3B sequestrates miR‐937‐5p to derepress TIMP3 and inhibit colorectal cancer progression

(2020) Wei Zeng et al.   Molecular Oncology

CircRNA CDR1as/miR-1287/Raf1 Axis Modulates Hepatocellular Carcinoma Progression Through MEK/ERK Pathway

(2020) Bashan Zhang et al.   Cancer Management and Research

Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis

(2020) Lei Chen et al.   Cancer Management and Research

Emerging Roles of Exosomal Circular RNAs in Cancer

(2020) Takahiro Seimiya et al.   Frontiers in Cell and Developmental Biology

CircPUM1 promotes hepatocellular carcinoma progression through the miR‐1208/MAP3K2 axis

(2020) Yaqiong Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Circular RNA profiling identifies circ102049 as a key regulator of colorectal liver metastasis

(2020) Qiaoming Zhi et al.   Molecular Oncology

Screening for functional circular RNAs using the CRISPR–Cas13 system

(2020) Siqi Li et al.   NATURE METHODS

CircAMOTL1 Promotes Tumorigenesis Through miR-526b/SIK2 Axis in Cervical Cancer

(2020) Zhengwei Sun et al.   Frontiers in Cell and Developmental Biology

CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1

(2019) Davide Barbagallo et al.   Cancers

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Circbank: a comprehensive database for circRNA with standard nomenclature

(2019) Ming Liu et al.   RNA Biology

The circRNA circP4HB promotes NSCLC aggressiveness and metastasis by sponging miR-133a-5p

(2019) Tao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression

(2019) Yi-Bo Xue et al.   Thoracic Cancer

The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p

(2019) Siliang Wei et al.   EBioMedicine

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

MicroRNA-411 and Its 5′-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia

(2019) Reginald V.C.T. van der Kwast et al.   MOLECULAR THERAPY

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

(2019) Zhenguo Liu et al.   Cell Death & Disease

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

(2019) Venkata Naga Srikanth Garikipati et al.   Nature Communications

Profiling and Bioinformatic Analyses Indicate Differential circRNA and miRNA/isomiR Expression and Interactions

(2018) Li Guo et al.   Biomed Research International

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

Characterizing isomiR variants within the microRNA-34/449 family

(2017) Olivier Mercey et al.   FEBS LETTERS

The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function

(2017) Zhen-Guo Yang et al.   MOLECULAR THERAPY

Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers

(2017) Luka Bolha et al.   International Journal of Genomics

MicroRNAs and their variants in an RNA world: implications for complex interactions and diverse roles in an RNA regulatory network

(2016) Li Guo et al.   BRIEFINGS IN BIOINFORMATICS

Epithelial-mesenchymal transition in tumor metastasis

(2016) Kay T. Yeung et al.   Molecular Oncology

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

(2016) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

In vitro circularization of RNA

(2016) Sabine Müller et al.   RNA Biology

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

5′ isomiR variation is of functional and evolutionary importance

(2014) Geok Chin Tan et al.   NUCLEIC ACIDS RESEARCH

A Novel miR-451a isomiR, Associated with Amelanotypic Phenotype, Acts as a Tumor Suppressor in Melanoma by Retarding Cell Migration and Invasion

(2014) Sankhiros Babapoor et al.   PLoS One

Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma

(2014) Michael N. Mavros et al.   JAMA Surgery

A highly expressed miR-101 isomiR is a functional silencing small RNA

(2013) Franc Llorens et al.   BMC GENOMICS

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

(2013) Jun-Hao Li et al.   NUCLEIC ACIDS RESEARCH

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Cancer biomarkers

(2012) N. Lynn Henry et al.   Molecular Oncology

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

IsomiRs – the overlooked repertoire in the dynamic microRNAome

(2012) Corine T. Neilsen et al.   TRENDS IN GENETICS

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

starBase: a database for exploring microRNA–mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data

(2010) Jian-Hua Yang et al.   NUCLEIC ACIDS RESEARCH

Repertoire and evolution of miRNA genes in four divergent nematode species

(2009) E. de Wit et al.   GENOME RESEARCH

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells

(2008) R. D. Morin et al.   GENOME RESEARCH