Article
Biotechnology & Applied Microbiology
Guang-Cheng Luo, Lin Chen, Jiang Fang, Zhi-Jian Yan
Summary: This study revealed that hsa_circ_0030586 is significantly upregulated in prostate cancer cells and may promote epithelial-mesenchymal transition (EMT) through the PI3K-AKT signaling pathway. Experiment results showed that interfering with hsa_circ_0030586 could inhibit tumor cell proliferation, migration, and invasion in PCa.
Article
Oncology
Jianhong Zhang, Zeming Hu, Chao Wen, Qicheng Liao, Baoqing He, Jing Peng, Xin Tang, Zhixi Chen, Yuankang Xie
Summary: The study found that miR-182 promotes EMT in GBC cells by targeting FOXN3, which in turn suppresses the Wnt/beta-catenin pathway. Decreased miR-182 expression led to attenuated EMT and reduced activity of beta-catenin and its downstream factors in GBC cells. Overexpression of FOXN3 improved EMT and the beta-catenin pathway.
Review
Oncology
Xiaoying Yang, Cheng Qin, Bangbo Zhao, Tianhao Li, Yuanyang Wang, Zeru Li, Tianyu Li, Weibin Wang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with poor prognosis. The molecular mechanisms of pancreatic oncogenesis and malignant progression are not fully understood. Recent studies have shown that long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) play important roles in the epithelial-mesenchymal transition (EMT) process in PDAC, affecting the migration and invasion of tumor cells. These RNAs can regulate the expression of EMT-related proteins through different mechanisms, thus influencing the development of cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaowen Zhang, Nan Wu, Jin Wang
Summary: The newly discovered circular RNA hsa-circ_0058106 is upregulated in laryngeal cancer and is associated with lymph node metastasis and advanced clinical stages. Silencing hsa-circ_0058106 inhibits migration and invasion of laryngeal cancer cells, and suppresses epithelial-mesenchymal transition (EMT). Mechanistically, hsa-circ_0058106 sponges miR-153 to regulate Snail1 expression and blocks the nuclear translocation of Twist1.
Article
Multidisciplinary Sciences
Nataly Naser Al Deen, Nadia Atallah Lanman, Shirisha Chittiboyina, Sophie Lelievre, Rihab Nasr, Farah Nassar, Heinrich Zu Dohna, Mounir AbouHaidar, Rabih Talhouk
Summary: RNA axes have been studied in breast cancer, but not used for risk assessment in early-onset breast cancer. By investigating in a breast epithelial culture model and a patient cohort, potential RNA biomarkers associated with breast cancer initiation risk were identified.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Mami Kurosaki, Mineko Terao, Dawei Liu, Adriana Zanetti, Luca Guarrera, Marco Bolis, Maurizio Gianni, Gabriela Paroni, Gregory J. Goodall, Enrico Garattini
Summary: Circular RNAs are important regulatory molecules in cellular processes and may be involved in tumor growth and diffusion. The circular RNA from the DOCK1 gene shows differential expression in breast cancer cell lines with different phenotypes and influences the expression of common genes. The study provides insights into the role of specific circular RNAs in the generation and progression of breast cancer.
Article
Biochemistry & Molecular Biology
M. Y. Cynthia Stafford, Declan J. McKenna
Summary: This paper investigates the expression and role of miR-182 in prostate cancer. The study finds that miR-182 is over-expressed in prostate cancer cells and is associated with clinical markers of disease progression. It also identifies MITF as a novel target of miR-182 in prostate cancer. The findings suggest that miR-182 could be a useful biomarker for diagnosing and predicting the prognosis of prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marketa Koleckova, Jiri Ehrmann, Jan Bouchal, Maria Janikova, Aneta Brisudova, Josef Srovnal, Katerina Staffova, Marek Svoboda, Ondrej Slaby, Lenka Radova, Katherine Vomackova, Bohuslav Melichar, Lucia Veverkova, Zdenek Kolar
Summary: Triple negative breast cancers (TNBC) are a morphologically and genetically heterogeneous group of breast cancers with uncertain prediction of biological behavior and response to therapy. Epithelial to mesenchymal transition (EMT) is a dynamic process characterized by loss of typical epithelial phenotype and acquisition of mesenchymal characteristics. The study aimed to analyze miRNA expression within areas of TNBCs with cellular morphology related to the EMT process, and found a specific miRNA expression profile of apocrine and spindle cell morphology which may be relevant for prognosis and therapy resistance of TNBC.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Chengxin Li, Lewei Zheng, Gaoran Xu, Qianqian Yuan, Ziyang Di, Yalong Yang, Xingxing Dong, Jinxuan Hou, Gaosong Wu
Summary: In this study, an EMT-related lncRNA signature was constructed to predict the prognosis of breast cancer patients. A risk score signature consisting of 10 lncRNAs associated with the EMT process was developed and validated. The signature was also evaluated for its impact on drug sensitivity and tumor immune cell infiltration in breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Medicine, Research & Experimental
Wenchang Lv, Yufang Tan, Mingchen Xiong, Chongru Zhao, Yichen Wang, Min Wu, Yiping Wu, Qi Zhang
Summary: This study identified a novel circRNA-based mechanism involved in breast cancer progression, revealing the correlation between circRNA-miRNA-m6A modulators and providing new diagnostic and therapeutic strategies for combating breast cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fatima Domenica Elisa De Palma, Francesco Salvatore, Jonathan G. Pol, Guido Kroemer, Maria Chiara Maiuri
Summary: The management of breast cancer relies on imaging, immunohistochemical and molecular evaluations. Circular RNAs (circRNAs) play a key role in breast cancer development and progression. They have potential as non-invasive biomarkers for diagnosis, prognosis and prediction in breast cancer.
Article
Medicine, Research & Experimental
Jun You, Yinan Chen, Donghan Chen, Yongwen Li, Tinghao Wang, Jingtao Zhu, Qingqi Hong, Qiyuan Li
Summary: In this study, the highly expressed circRNA circ_0001789 was identified in gastric cancer tissues. Silencing circ_0001789 attenuated the malignancy of gastric cancer cells, and exosomal circ_0001789 was sufficient to regulate the malignant phenotype of gastric cancer cells. miR-140-3p was identified as a downstream target of circ_0001789, negatively correlated with circ_0001789 expression in gastric cancer tissues. Overexpression of miR-140-3p suppressed cell migration, invasion, and epithelial-mesenchymal transition in gastric cancer cells, and PAK2 was identified as the target of miR-140-3p to mediate the malignant phenotype of gastric cancer cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Meina Jiang, Shuai Fang, Xiaodong Zhao, Chengwei Zhou, Zhaohui Gong
Summary: EMT plays a crucial role in cancer development, especially in lung carcinoma. CircRNAs are involved in EMT-related cell invasion and metastasis, and may become promising biomarkers and therapeutic targets in cancer management.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Cell Biology
Su-jin Yang, Dan-dan Wang, Shan-liang Zhong, Wen-quan Chen, Feng-liang Wang, Jian Zhang, Wen-xiu Xu, Di Xu, Qian Zhang, Jian Li, He-da Zhang, Jun-chen Hou, Ling Mao, Jin-hai Tang
Summary: This study reveals that circPSMA1 functions as a tumor promoter in triple-negative breast cancer (TNBC) by acting as a miRNA sponge to absorb miR-637 and regulate Akt1-beta-catenin (cyclin D1) axis. Exosomes from TNBC cells carrying high levels of circPSMA1 can transmit migration and proliferation capacity to recipient cells. High expression of Akt1 and low expression of miR-637 are highly correlated with poor prognosis in TNBC patients with lymph node metastasis.
CELL DEATH & DISEASE
(2021)
