Article
Environmental Sciences
Liguo Zhang, Ping Zhang, Tonggang Liu, Dongmei Li, Xianxian Liu
Summary: circ_0006404 is overexpressed in hepatocellular carcinoma (HCC) and promotes HCC cell growth, cycle, and migration. It functions by regulating the expression of miR-624. These findings suggest that circ_0006404 may serve as a new biomarker for HCC.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Minyong Chen, Huaxiang Wang, Songchang Shi, Hui Zhang, Shaohua Xu, Yi Jiang
Summary: This study found that the expression of miR-6071 was decreased in liver cancer stem cells (LCSCs). Overexpression of miR-6071 inhibited self-renewal and tumorigenesis of LCSCs, as well as proliferation and migration of hepatocellular carcinoma (HCC) cells. The study also revealed that miR-6071 targeted the 3’UTR of PTPN11 mRNA and that upregulation of miR-6071 sensitized HCC cells to lenvatinib treatment. Clinical analysis showed that HCC patients with high miR-6071 expression had better survival outcomes with postoperative lenvatinib treatment.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Environmental Sciences
Hua Li, Bingli Liu, Xin Xu, Shunle Li, Di Zhang, Qingfeng Liu
Summary: This study revealed the regulatory role of circ_SNX27 in hepatocellular carcinoma (HCC) development through the miR-637/FGFR1 axis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Masamichi Hayashi, Suguru Yamada, Keisuke Kurimoto, Hiroshi Tanabe, Sho Hirabayashi, Fuminori Sonohara, Yoshikuni Inokawa, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera
Summary: miR-23b-3p is found to function as an oncogenic microRNA in HCC cell lines. Overexpression of miR-23b-3p in resected HCC tissues is a significant prognostic factor of overall survival. Both MICU3 and AUH may be candidate gene targets of miR-23b-3p.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Ying Zhan, Yichen Song, Wei Qiao, Lu Sun, Xin Wang, Bolong Yi, Xinyu Yang, Lian Ji, Peng Su, Wujun Zhao, Zhijun Liu, Weidong Ren
Summary: This study demonstrates that exosomes combined with focused ultrasound (FUS) have the potential to be an effective treatment for glioma. The researchers found that using exosomes as carriers for miR-1208 and combining it with FUS could enhance the uptake of miR-1208 by glioma cells, leading to efficient tumor suppression. Further clinical evaluation of this treatment is warranted.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Thorben Fruendt, Linda Krause, Elaine Hussey, Bettina Steinbach, Daniel Koehler, Johann von Felden, Kornelius Schulze, Ansgar W. Lohse, Henning Wege, Heidi Schwarzenbach
Summary: Exosomes carrying small non-coding RNA, particularly miR-16, miR-146a, miR-192, and miR-221, appear to be promising diagnostic and prognostic markers for hepatocellular carcinoma (HCC) and liver cirrhosis patients. MiR-146a showed potential as a diagnostic marker for distinguishing HCC patients from liver cirrhosis patients, while miR-192 independently correlated with overall survival in HCC patients.
Article
Oncology
Tingting Lu, Tao Han, Mingfang Zhao
Summary: miR-3168 is increased in liver cancer stem cells (CSCs) and inhibits CSC expansion by targeting p53 directly. Additionally, miR-3168 may be a predictor of survival benefits from transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. The study uncovers a novel mechanism of liver CSC regulation and provides a potential therapeutic target for liver CSCs.
Article
Oncology
Yuan Wei, Lai Wei, Tao Han, Shuang Ding
Summary: This study reveals the elevated expression of miR-3154 in hepatocellular carcinoma (HCC) and its association with patient survival. Inhibiting miR-3154 suppresses self-renewal, proliferation, metastasis, and tumorigenesis of HCC cells. The mechanism involves the direct targeting of HNF4 alpha by miR-3154. Furthermore, miR-3154 may predict the clinical benefit of lenvatinib treatment in HCC patients.
Article
Genetics & Heredity
Shuying Chen, Zile Fu, Shuzhan Wen, Xiaoyi Yang, Chengxuan Yu, Wenhan Zhou, Yong Lin, Yuan Lv
Summary: miR-497 and miR-1246 may serve as biomarkers in HCC by regulating target genes involved in the progression of the disease. Their expression levels are significantly associated with prognosis and diagnosis of HCC.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Patricia de la Cruz-Ojeda, Tobias Schmid, Loreto Boix, Manuela Moreno, Victor Sapena, Juan M. Praena-Fernandez, Francisco J. Castell, Juan Manuel Falcon-Perez, Maria Reig, Bernhard Bruene, Miguel A. Gomez-Bravo, Alvaro Giraldez, Jordi Bruix, Maria T. Ferrer, Jordi Muntane
Summary: The study reveals that Sorafenib regulates a specific miRNA signature, where miR-200c-3p, miR-222-5p, and miR-512-3p have prognostic value and contribute to treatment response.
Article
Immunology
Guanbin Lin, Jingjing Li, Kan Chen, Aiping Wang, Chuanyong Guo
Summary: This study found that circ_0000854 promotes the progression of HCC through the miR-1294/IRGQ axis, providing a novel regulatory mechanism for HCC pathogenesis.
CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haihong Hu, Yu Wang, Zhiyuan Qin, Wen Sun, Yanhong Chen, Jiaqi Wang, Yingying Wang, Jing Nie, Lu Chen, Sheng Cai, Lushan Yu, Su Zeng
Summary: In this study, miR-4524-5p was found to downregulate the expression of MRP4, and circHIPK3 was shown to regulate MRP4 expression by sponging miR-124-3p and miR-4524-5p for the first time. These results may offer new insights into preventing MRP4-related proliferation and multiple drug resistance in HCC.
Article
Medical Laboratory Technology
Yujia Fang, Dong Yan, Lixin Wang, Jie Zhang, Qingfang He
Summary: This study analyzed the differential expression of miRNAs between HCC patients and controls and found that miR-16 and miR-122 were significantly upregulated in early-stage HCC patients. Combining these miRNAs with AFP improved the diagnostic efficacy for HCC. Furthermore, miR-16 and miR-122 were found to regulate a number of potential target genes involved in cancer pathways.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Lingyun Ma, Shigui He, Helan Li, Shengli Zhang, Yi Yin
Summary: Abnormally expressed long non-coding RNAs (lncRNAs) play important roles in cardiovascular disease, but their role in atherosclerosis (AS) is still unclear. This study focused on HAND2 Antisense RNA 1 (HAND2-AS1) and found that it could alleviate foam cell formation within AS by targeting the miR-128/SIRT1 axis, suggesting it may be a potential therapeutic target for AS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuan-Yuan Luo, Ke-Gong Tao, Yi-Ting Lu, Bin-Bin Li, Kai-Ming Wu, Chen-Hong Ding, Fang-Zhi Yan, Yue Liu, Yong Lin, Xin Zhang, Xin Zeng
Summary: This study identified hsa_circ_0098181 as a potential therapeutic target for hepatocellular carcinoma (HCC). The downregulation of hsa_circ_0098181 was associated with poor prognosis in HCC patients. Hsa_circ_0098181 sponge miR-18a-3p to regulate PPARA, inhibiting the proliferation, invasion, migration, and colony formation of HCC cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qiao Jin, Qinghua Zhang, He Bai, Amanda Huon, Timothy Charlton, Shengru Chen, Shan Lin, Haitao Hong, Ting Cui, Can Wang, Haizhong Guo, Lin Gu, Tao Zhu, Michael R. Fitzsimmons, Kui-juan Jin, Shanmin Wang, Er-Jia Guo
Summary: By synthesizing single-crystalline and precisely controlled Fe3N thin films, this study demonstrates the maintenance of high-temperature ferromagnetism in thin Fe3N layers and reveals strong in-plane anisotropy and changing anomalous Hall resistivity. Additionally, a significant exchange bias is observed at the Fe3N and CrN interfaces. This work provides guidance for exploring functional nitride films and their potential applications.
ADVANCED MATERIALS
(2023)
Review
Astronomy & Astrophysics
Jin Qiao, Zhao Li, Tao Zhu, Ran Ji, Guoliang Li, Wen Zhao
Summary: The examination of parity symmetry in gravitational interactions has gained attention, and theories of parity-violating gravity have been proposed. This review summarizes the progress of these theories and focuses on their observable effects in gravitational waves (GWs), particularly the difference between polarization modes. It explores the implications of these theories for GWs generated by compact binary coalescences and primordial GWs. The current and potential constraints on the parity-violating energy scales are presented using current and future GW observations.
FRONTIERS IN ASTRONOMY AND SPACE SCIENCES
(2023)
Review
Education & Educational Research
Hongyang Chen, Zining Wang, Lan Zheng, Jiumei Ciren, Weiyi Zhang, Tao Zhu
Summary: Anesthesiology education in Tibet lags behind, and clinical anesthesia needs improvement. Improving the overall quality of anesthesiology teachers in Tibet is advantageous for the development of local anesthesiology. Enhancing the teaching ability of anesthesiologists not only promotes the independent learning capability of young doctors, but also establishes a strong foundation for the smooth progress of clinical work.
FRONTIERS IN EDUCATION
(2023)
Article
Energy & Fuels
Mengye Jin, Tao Zhu, Shouheng Li, LiFeng Wang, Yusheng Liu, Yan Yu, Yiwei Han
Summary: In this study, CeMnOx-ZF catalysts with different metal loadings were prepared from coal fly ash (CFA) and their catalytic oxidation effects on toluene were investigated. The synergy between Ce and Mn metals in CeMnOx-ZF catalysts was studied. The optimized conditions for highest activity of CFA were determined, and the 20 wt.% CeMnOx-ZF catalyst exhibited a high toluene removal efficiency of up to 99.6% under optimized reaction conditions. The catalyst also showed high stability even after a 100-hour cycle test. This study provides a simple method for CFA activation and proposes a feasible strategy for designing high-efficiency catalysts for VOC degradation.
Article
Optics
Ligang Huang, Shunli Liu, Chaoze Zhang, Yanxiang Zhao, Laiyang Dang, Lei Gao, Wei Huang, Guolu Yin, Tao Zhu
Summary: This article proposes and demonstrates an acousto-optic reconfigurable filter (AORF) based on vector mode fusion in dispersion-compensating fiber (DCF). The resonance peaks of different vector modes in the same scalar mode group can be effectively fused into a single peak, allowing for arbitrary reconfiguration of the filter. In the experiment, the AORF's bandwidth can be electrically tuned from 5 nm to 18 nm by superimposing different driving frequencies. The AORF also demonstrates multi-wavelength filtering and the ability to reconfigure between bandpass and band-rejection modes by setting the combination of driving frequencies.
Article
Chemistry, Analytical
Guolu Yin, Zhaohao Zhu, Min Liu, Yu Wang, Kaijun Liu, Kuanglu Yu, Tao Zhu
Summary: We proposed an optical frequency domain reflectometry (OFDR) based on a multilayer perceptron (MLP) to train and grasp the fingerprint features of Rayleigh scattering spectrum in the optical fiber. The method achieves a larger measurement range, better measurement accuracy, and is less time-consuming compared to the traditional cross-correlation algorithm. This is the first time that machine learning has been introduced into an OFDR system, which brings new knowledge and optimization to the system.
Article
Medicine, General & Internal
Yusi Hua, Qiyuan Huang, Guo Chen, Tao Zhu
Summary: This study aims to investigate the effect of ultrasound-guided anterior superior laryngeal nerve block on awake videolaryngoscopes-assisted endotracheal intubation in adult elective surgery patients, and compare the effectiveness and safety to traditional ultrasound-guided posterior superior laryngeal nerve block.
Article
Immunology
Yidan Tang, Weizhi Liu, Weishuang Kong, Shuangyi Zhang, Tao Zhu
Summary: This study used a two-sample Mendelian randomization method to investigate the causal relationship between chronic pain and autoimmune diseases (AIDs). The results showed a causal relationship between multisite chronic pain and multiple sclerosis (MS) and rheumatoid arthritis (RA).
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Yingyang Li, Wenjing Yu, Lamei Li, Qianqian Yao, Kexin Jiang, Tao Zhu, Enshe Jiang
Summary: Cancers have become the leading cause of death in China, greatly impacting the health and lives of residents. Oncology nursing focuses on cancer education, prevention, detection, and palliative care. While China has made progress in developing oncology nursing, there are still challenges that need to be addressed to ensure access to cancer care for more individuals.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Transportation Science & Technology
Jingke Zhang, Tao Zhu, Bing Yang, Xiaorui Wang, Shoune Xiao, Guangwu Yang, Yanwen Liu, Quanwei Che
Summary: Rail vehicles generate enormous longitudinal impact loads during collisions, and if there is a mismatch between the compressive strength of the intermediate coupler and the structural strength of the car body, the risk of car body damage and train derailment increases. In this study, a four-stage rigid-flexible coupling finite element model of the coupler is established, taking into account the coupler buckling load. The influence of the coupler buckling load on the train's longitudinal-vertical-horizontal buckling behavior is investigated, and the mechanism of horizontal buckling instability in train collisions is revealed.
RAILWAY ENGINEERING SCIENCE
(2023)
Article
Chemistry, Physical
Qi Zhou, Yu-Xuan Peng, Ping Wang, Zhong-Ying Jiang, Xin-Jun Zhao, Tao Zhu
Summary: The study aims to clarify the molecular mechanism underlying the asymmetric solution-induced membrane shape transition in lipid bilayers. Using giant unilamellar vesicles (GUVs) as model membranes, the interaction of fully hydrated lipid membranes with two distinct sugar solutions was investigated. The experimental observations revealed that asymmetric sugar solutions induce spontaneous curvature in the phospholipid bilayer, resulting in the formation of outward(/inward) budding vesicles over a wide range of parameters.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Automation & Control Systems
Minghui Chen, Ming Cai, Yadong Gong, Tao Zhu, Qiang Gong, Yu Liu
Summary: This study presents a novel three-dimensional simulation model for Abaqus multi-grit grinding developed using Python's secondary capabilities. The model uses a characteristic distribution pattern to arrange 48-sided abrasive grains on a cylinder, simulating a 200-grit micro-abrasive rod. Through considering various parameters, such as spindle speeds, grinding depths, and feed rates, the model explores the impact of multi-grit on the surface profiles of chips and workpieces for the nickel-based single-crystal Superalloy DD5. The findings from the multi-grain simulation provide valuable insights into the dynamics of multi-grit grinding processes and optimization strategies.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Immunology
Changliang Liu, Jiahui Wu, Ming Li, Rui Gao, Xueying Zhang, Shixin Ye-Lehmann, Jiangning Song, Tao Zhu, Chan Chen
Summary: This study found that elevated Smad7 in the hippocampal CA1 region can enhance neuroinflammation and apoptosis, leading to learning and memory impairment after surgery. Therefore, Smad7 may be a potential therapeutic target for the treatment of memory impairment after anesthesia surgery.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Optics
Wang Yu, Xiao Di, Niu Yangyang, Yang Jie, Yang Pengxi, Zhu Zhaohao, Yin Guolu, Zhu Tao
Summary: Objective Fiber optic hydrophones are underwater acoustic sensors that convert sound signals into optical signals for data processing. They have high sensitivity, resistance to electromagnetic radiation, and are suitable for harsh conditions. With the increase in maritime activities, research on hydrophone arrays has become important. However, the probe technology is crucial for the stability and performance of hydrophones. This study proposes a high-precision measurement method based on optical frequency domain reflectometry to monitor the deformation of hydrophone probes.
ACTA OPTICA SINICA
(2023)
Article
Optics
Laiyang Dang, Ligang Huang, Leilei Shi, Fuhui Li, Guolu Yin, Lei Gao, Tianyi Lan, Yujia Li, Lidan Jiang, Tao Zhu
Summary: This study proposes a new method to deeply purify laser spectrum with compact size under normal conditions, by effectively suppressing the spontaneous radiation of the laser cavity through weak external distributed perturbation. By injecting a feedback signal with continuous spatio-temporal phase transition controlled by a distributed feedback structure into the main cavity, the coupling rate from the spontaneous radiation to the stimulated emission can be deeply suppressed, resulting in an extremely purified laser spectrum. Eventually, an ultra-narrow linewidth on-chip laser system with excellent performance is successfully obtained under normal conditions.
OPTO-ELECTRONIC ADVANCES
(2023)
