Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis

Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.

Automated summary

The highly expressed circular RNA hsa_circ_0007967 in gastric cancer was found to promote cell proliferation by acting as a sponge for miR-411-5p and increasing MAML3 expression. This suggests that hsa_circ_0007967 could serve as a potential biomarker for gastric cancer diagnosis and a target for treatment.