Article
Cell Biology
Yan Cui, Xintong Zhao, Yangang Wu
Summary: This study found that circ_0005918 is overexpressed in intervertebral disc degeneration (IDD) and promotes cell growth, ECM degradation, and secretion of inflammatory cytokines. Furthermore, circ_0005918 acts through sponging miR-622, and the expression level of miR-622 is correlated with the severity of IDD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
You Zhou, Yingjie Shao, Wenwei Hu, Jinping Zhang, Yufang Shi, Xiangyin Kong, Jingting Jiang
Summary: The SP100-AS1/miR-622/ATG3 axis plays a crucial role in radioresistance and autophagic activity in colorectal cancer, indicating its potential as a therapeutic target to improve the response to radiation therapy.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Medicine, Research & Experimental
Juan Lu, Zhongyang Xie, Zhaoying Xiao, Danhua Zhu
Summary: miR-622, a type of miRNA, has been shown to influence disease progression in various tumors, including liver, colorectal, and breast cancer, as well as glioma. Studying the expression levels and mechanisms of miR-622 helps to understand its role in tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Li-Feng Dong, Fang-Fang Chen, Yang-Fan Fan, Kun Zhang, Hui-Hui Chen
Summary: This study reported the function and mechanism of circ-0000512 in the progression of triple-negative breast cancer (TNBC). The results showed that circ-0000512 was upregulated in TNBC patients and its knockdown attenuated cell proliferation and migration while enhancing apoptosis. Furthermore, circ-0000512 promoted PD-L1 ubiquitination by sponging the miR-622/CMTM6 axis, thus promoting TNBC progression and immune escape.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu, Weiyu Shen
Summary: This study found that circBCAR3 is highly expressed in esophageal cancer and it can promote the tumorigenesis of esophageal cancer by interacting with miR-27a-3p to upregulate TNPO1. The splicing factor QKI was identified as a positive regulator of circBCAR3 and hypoxia upregulates E2F7 to transcriptionally activate QKI.
Article
Endocrinology & Metabolism
Gaopeng Xiao, Liuqiong Yu, Wenmin Tan, Hao Yang, Wensen Li, Rongzhou Xia, Yujin Li
Summary: Propofol restrains glioma progression through regulating the circMAPK4/miR-622/HOXA9 axis, resulting in inhibition of glioma cell growth, migration, and invasion in vitro.
METABOLIC BRAIN DISEASE
(2023)
Article
Oncology
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
Summary: The study revealed that circ_0119872 is upregulated in UM cell lines and tissues, promoting the malignancy of UM cells. Additionally, circ_0119872 can directly interact with miR-622, acting as a miRNA sponge to regulate the expression of the miR-622 target gene G3BP1 and downstream Wnt/beta-catenin and mTOR signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Kexin Li, Jiongyu Chen, Xiaoying Lou, Yiling Li, Benheng Qian, Danfei Xu, Yue Wu, Shaohui Ma, Donghong Zhang, Wei Cui
Summary: The study revealed that the dynamic changes in 25 m6A regulators were associated with the clinical features and prognosis of patients with esophageal cancer, with HNRNPA2B1 possibly affecting the prognosis of esophageal cancer patients by regulating the miR-17-92 cluster.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Jingpeng Wang, Shuyuan Li, Gaofeng Zhang, Huihua Han
Summary: Sevoflurane inhibits colorectal cancer progression, and hsa_circ_0000231 attenuates Sev-induced repression by acting as a sponge of miR-622. These findings suggest a potential anesthetic protocol for CRC patients undergoing surgery.
JOURNAL OF BIOLOGICAL RESEARCH-THESSALONIKI
(2021)
Article
Biochemistry & Molecular Biology
Bin Guo, Ziqiang Tian
Summary: This study confirmed the overexpression of miR-25 in esophageal squamous cell carcinoma tumor tissue and its association with poor prognosis. miR-25 promotes ESCC progression by directly inhibiting the expression of BTG2.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Rui Hu, Rui Bi, Lianyong Jiang, Haibo Xiao, Xiao Xie, Hongtao Liu, Fengqing Hu
Summary: The study discovered that the overexpression of lncRNA RP11-465B22.8 in EC is associated with poor survival in patients, by sponging miR-765 to increase the expression of KLK4, promoting proliferation, migration, and invasion of EC cells, and being transferred from EC cells to macrophages via exosomes to induce cell migration and invasion.
CELL DEATH DISCOVERY
(2021)
Article
Andrology
Niloufar Targhazeh, Bahman Yousefi, Samira Asghari, Reza Mohammadnejhad, Parinaz Mansouri, Amir Valizadeh
Summary: This study found that miR-622 modulates the metastasis of PCa cells by targeting metastatic genes, confirming its tumor-suppressive function in PCa cells by enhancing apoptosis and reducing metastasis.
Article
Oncology
Pornima Phatak, Mohan E. Tulapurkar, Whitney M. Burrows, James M. Donahue
Summary: MiR-199a-5p functions as a tumor suppressor in esophageal cancer cells by regulating cellular proliferation, partially through repression of Jun B.
Article
Oncology
Shuchang Ren, Xiaohui Tan, Melinda Z. Fu, Shuyang Ren, Xiaoling Wu, Tao Chen, Patricia S. Latham, Paul Lin, Yan-gao Man, Sidney W. Fu
Summary: In esophageal cancer, miR-375 is frequently downregulated and acts as a tumor suppressor by blocking the ERBB2/VEGFA pathway to inhibit cancer progression.
Article
Biotechnology & Applied Microbiology
Jian Yang, Jian Lu, Ni Yin, Jingyue Sun, Jianhong Pu, Jin Zang
Summary: The study found that miR-622 was downregulated and NUAK1 was upregulated in GC, with NUAK1 potentially being a target of miR-622. Knocking down NUAK1 decreased GC cell proliferation and migration, while increasing oxidative stress in vitro and inhibiting tumor development in vivo. miR-622 acted through the miR-622/NUAK1/p-protein kinase B (Akt) axis to suppress NUAK1's function, thereby inhibiting the occurrence of GC.
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.