Journal
CANCER CELL INTERNATIONAL
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12935-021-02017-4
Keywords
Circular RNA; Signaling pathways; Human cancer; Biomarkers; miRNA sponging
Categories
Funding
- NCI [CA2070313, CA140410]
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Circular RNAs play a significant role in cancer as diagnostic and prognostic biomarkers and therapeutic targets. They regulate cell signaling pathways by modulating particular gene expressions in different cancers.
Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differentially expressed in various cancer cell lines and regulate cell signaling pathways by modulating particular gene expressions. Understanding their role in these pathways and what cancers they are found in can set the stage for identifying diagnostic and prognostic biomarkers and therapeutic targets of cancer. This paper will discuss which circRNAs are found in different cancers and what mechanisms they use to upregulate or downregulate certain cellular components.
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