Review
Biochemistry & Molecular Biology
Qingshui Wang, Youyu Lin, Wenting Zhong, Yu Jiang, Yao Lin
Summary: DAPKs family plays a crucial role in the development of malignant tumors, while non-coding RNAs are involved in the regulation of DAPKs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Cell Biology
Hui Kong, Ming-Li Sun, Xin-An Zhang, Xue-Qiang Wang
Summary: By investigating the roles and interactions of miRNA, lncRNA, and circRNA in osteoarthritis, their significance in the prevention, diagnosis, and treatment of OA can be identified as potential future therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Jie Liu, Gang Zhao, Xin-Li Liu, Ge Zhang, Shi-Qi Zhao, Shi-Long Zhang, Li-Heng Luo, Da-Chuan Yin, Chen-Yan Zhang
Summary: Non-coding RNAs (ncRNAs) play important roles in the occurrence and development of triple negative breast cancer (TNBC), and may serve as potential therapeutic targets.
Review
Cell Biology
Xixia Zhang, Jing Yang
Summary: Head and neck cancers (HNCs) are a common and deadly form of cancer worldwide, with radiotherapy being a common treatment method. However, the overall survival rates for patients are still low. Studies have shown that non-coding RNAs (ncRNAs) play a role in regulating the sensitivity of HNC cancer cells to radiotherapy, potentially affecting the response of cancer cells to treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Arshi Waseem, Abdul Quaiyoom Khan, Mohsin Ali Khan, Rehan Khan, Shahab Uddin, Johannes Boltze, Syed Shadab Raza
Summary: Stroke is a leading cause of death and disability worldwide, but effective treatments are limited. Abnormal expression of various non-coding RNAs (ncRNAs) has been found after stroke, affecting processes such as neurogenesis, angiogenesis, apoptosis, and autophagy. Understanding the roles and mechanisms of ncRNAs holds promise for future stroke treatments, as they can modify the impact and progression of stroke on a molecular level. Exploring the functions and underlying mechanisms of ncRNAs after stroke may reveal new therapeutic targets and improve diagnostics for stroke.
Review
Biochemistry & Molecular Biology
Eleonora A. Braga, Marina V. Fridman, Alexey M. Burdennyy, Vitaly I. Loginov, Alexey A. Dmitriev, Irina V. Pronina, Sergey G. Morozov
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in the pathogenesis of non-small-cell lung cancer (NSCLC), primarily through competing binding with microRNAs (miRNAs). However, other mechanisms involving RNA-binding proteins (RBPs) that increase the stability of target mRNAs, and potential involvement of lncRNAs in m6A modification, have also been reported. Analysis of target proteins using the DAVID database and protein interactions using the STRING website revealed that JAK-STAT and Hippo signaling pathways, cytokine pathways, VEGFA-VEGFR2 pathway, cell cycle regulation, and neovascularization are the most relevant pathways affected by lncRNAs in NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Tong Bu, Le Li, Jiyu Tian
Summary: Prostate cancer is one of the most common cancers in males, and it poses challenges in diagnosis and treatment. Non-coding RNAs play important regulatory roles in the occurrence and development of prostate cancer, particularly in the regulation of the Wnt signaling pathway. Aberrant expression of these ncRNAs and dysregulation of the Wnt signaling pathway contribute to cell proliferation, apoptosis, invasion, migration, and angiogenesis in prostate cancer, and they also show promise as diagnostic and prognostic biomarkers.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Oliver Treeck, Silke Haerteis, Olaf Ortmann
Summary: Endocrine therapy is a common treatment for estrogen-responsive breast cancer, but resistance to this therapy is a major clinical problem. Non-coding RNAs (ncRNAs) have been found to affect the estrogen response and reduce the efficacy of endocrine therapy. These ncRNAs could be used as biomarkers to predict therapy response and as potential targets to overcome endocrine resistance.
Review
Immunology
Chunxiang He, Ze Li, Miao Yang, Wenjing Yu, Rongsiqing Luo, Jinyong Zhou, Jiawei He, Qi Chen, Zhenyan Song, Shaowu Cheng
Summary: This review investigates the role of non-coding RNA (ncRNA) in the activation and polarization of microglial cells in Alzheimer's disease (AD). The mechanisms through which ncRNA regulates microglial activation are still not fully understood, and further research is needed to understand the effects of ncRNA in different polarization states. However, ncRNA-based drugs hold promise as a new therapeutic approach in AD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Medicine, Research & Experimental
Benchi Ma, Shihao Wang, Wenzheng Wu, Pufan Shan, Yufan Chen, Jiaqi Meng, Liping Xing, Jingyi Yun, Longhui Hao, Xiaoyu Wang, Shuyan Li, Yinghui Guo
Summary: In recent years, significant progress has been made in bioinformatics with the discovery of functional non-coding RNAs (ncRNAs). These ncRNAs play a crucial role in regulating intracellular gene expression, assisting in diagnosis, guiding drug use, and determining prognosis in various diseases. MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are the three major types of ncRNAs that interact with each other. Studies have shown that lncRNAs and circRNAs can sponge miRNAs, influencing normal physiological processes and regulating mRNA expression, and ultimately affecting cellular physiology. This paper provides a summary of the mechanisms and research progress of these three ncRNAs and their potential implications in disease diagnosis, treatment, and drug development.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Yi-Li Zheng, Ge Song, Jia-Bao Guo, Xuan Su, Yu-Meng Chen, Zheng Yang, Pei-Jie Chen, Xue-Qiang Wang
Summary: Musculoskeletal degenerative diseases (MSDDs) encompass a range of pathological conditions affecting muscle, bone, cartilage, joints, and connective tissues. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) play key roles in biological regulation and are potential targets for therapeutic interventions in MSDD. Further research is needed to uncover the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in MSDD pathology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Hongmei Shi, Yang He, Xuzhen Li, Yanli Du, Jinbo Zhao, Changrong Ge
Summary: This review summarizes the ncRNAs involved in the skeletal muscle growth and development of domestic chickens and discusses the potential limitations and challenges.
Review
Cell Biology
Sabah Nisar, Ajaz A. Bhat, Mayank Singh, Thasni Karedath, Arshi Rizwan, Sheema Hashem, Puneet Bagga, Ravinder Reddy, Farrukh Jamal, Shahab Uddin, Gyan Chand, Davide Bedognetti, Wael El-Rifai, Michael P. Frenneaux, Muzafar A. Macha, Ikhlak Ahmed, Mohammad Haris
Summary: circRNAs are a class of evolutionarily conserved non-coding endogenous RNAs found in the eukaryotic transcriptome, with structural stability, high expression, and tissue-specific expression. They function as sponges for miRNAs and RBPs, regulators of transcription, translation, and splicing events, and play roles in various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Ying Tang, Jinghui Bao, Jiahui Hu, Leiling Liu, Dan-Yan Xu
Summary: Circular RNAs (circRNAs) are a group of endogenous non-coding RNAs that widely exist in human tissues, including the heart, and play crucial regulatory roles in cardiovascular diseases (CVDs). They are conserved, stable and have specific spatiotemporal expression, making them potential diagnostic markers or prognostic biomarkers for CVDs.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Bimaljeet Kour, Suruchi Gupta, Ravail Singh, Yengkhom Sophiarani, Prosenjit Paul
Summary: circRNAs, formed by back splicing process, exhibit stability and tissue specificity, holding potential as diagnostic biomarkers for various diseases. With their multiple modes of action, circRNAs are recognized as a latent method for early disease detection and treatment efficacy.
MOLECULAR GENETICS AND GENOMICS
(2022)
Review
Immunology
Keywan Mortezaee, Jamal Majidpoor
Summary: Tumor-associated macrophages (TAMs) are immune cells that infiltrate tumor areas and have intense interactions with other cells. The metabolic abnormalities in tumors can affect the polarization of macrophages towards pro-tumor or anti-tumor phenotypes. Adjusting the metabolic systems of macrophages can be an effective tool in cancer therapy.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Soudeh Ghafouri-Fard, Hamed Shoorei, Bashdar Mahmud Hussen, Peixin Dong, Tianyue Zhai, Mohammad Taheri, Mohammad Samadian
Summary: N6-methyladenosine (m6A) is a common endogenous modification that affects the expression of eukaryotic mRNA transcripts. Recent studies have shown that m6A marks in non-coding RNAs can also impact their functions and expression, similar to mRNA-coding genes. Understanding the role of m6A marks in the regulation of non-coding RNA expression can provide insights into the mechanisms of various disorders and potentially lead to new therapeutic approaches, especially for cancers. Additionally, non-coding RNAs themselves can influence m6A levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Cell Biology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Mohammad Taheri, Arda Kiani
Summary: Sarcopenia is a disease characterized by muscle atrophy and frailty in older adults, with the underlying molecular mechanisms still unclear. Noncoding RNAs, particularly microRNAs and long noncoding RNAs, have been identified as playing a role in the development and progression of sarcopenia. This manuscript reviews the current understanding of their involvement and discusses their potential as therapeutic targets.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jalal Gharesouran, Hassan Hosseinzadeh, Ali Naghiloo, Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Mohammad Taheri, Maryam Rezazadeh, Mohammad Samadian
Summary: This study reports a case of CMT, a hereditary neuropathy, in which the patient developed symptoms late in life. A novel 4074 bp homozygote deletion in the MPZ gene was identified through exome sequencing. The study suggests the presence of another protein in peripheral nervous system myelin biogenesis to compensate for the lack of MPZ protein.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Neda Abedpour, Hamed Shoorei, Farzad Rajaei
Summary: This study aimed to evaluate the effects of vitrification on fertilization rate and expression of integrin genes in mice oocytes. The results showed that vitrified oocytes had a lower fertilization rate and altered expression of integrin genes compared to non-vitrified oocytes.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Neurosciences
Soudeh Ghafouri-Fard, Ashkan Pourtavakoli, Bashdar Mahmud Hussen, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Autism spectrum disorder (ASD) is a common neurodevelopmental disease, affecting approximately 1 in 59 individuals. The disorder is genetically heterogeneous, with both inheritable and de novo mutations in several genes playing a role. The review discusses the different types of mutations, including missense and nonsense mutations, as well as copy number variations, found in individuals affected by ASD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hani Sabaie, Parham Tamimi, Jalal Gharesouran, Zoha Salkhordeh, Mohammad Reza Asadi, Mirmohsen Sharifi-Bonab, Zeinab Shirvani-Farsani, Mohammad Taheri, Arezou Sayad, Maryam Rezazadeh
Summary: Alzheimer's disease (AD) is a complex global health problem, and new methodologies are needed to investigate its pathophysiology and develop treatments. The interaction of immune modulation and neurodegeneration offers potential for discovering biomarkers and therapies. In this study, we compared the expression levels of inhibitory B7 family members in the blood of AD patients and healthy individuals, and found that certain members were significantly higher in patients. These findings suggest the potential of these molecules as diagnostic biomarkers for AD.
METABOLIC BRAIN DISEASE
(2023)
Article
Endocrinology & Metabolism
Soudeh Ghafouri-Fard, Sara Ahmadi Teshnizi, Shahryar Azizi, Solat Eslami, Mohammad Taheri, Fariborz Rashnoo
Summary: Obesity is a global problem influenced by genetic factors. The study found an association between the GRM7 gene and obesity.
METABOLIC BRAIN DISEASE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Sara Ahmadi Teshnizi, Bashdar Mahmud Hussen, Mohammad Taheri, Hakimeh Zali
Summary: This review summarizes recent studies on the expression of GHET1, its in vitro functions, and its impact on the beginning and progression of cancer based on xenograft models, highlighting the correlation between up-regulation of GHET1 and poor prognosis in various malignancies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Maryam Khaledabadi, Ghazal Najafi, Arash Safarzadeh, Bashdar Mahmud Hussen, Solat Eslami, Guive Sharifi, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: This study evaluated the expression of 5 long non-coding RNAs (lncRNAs) in non-functioning pituitary adenomas (NFPAs) and found that the expression of ATP6V0E2-AS1, EPB41L4A-AS1, FGD5-AS1, and WWC2-AS2 was significantly increased in NFPAs. However, the expression of ARHGAP5-AS1 did not differ. Additionally, there were significant positive associations between age of NFPA patients and invasiveness of NFPA, diseases duration and CSF leak, as well as tumor size and Knosp classification and invasiveness of NFPA. This study provides valuable information on lncRNA dysregulation in NFPAs and calls for further research in this field.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Farzaneh Abbasi, Amir Nicknam, Bashdar Mahmud Hussen, Solat Eslami, Nader Akbari Dilmaghani, Mohammad Taheri, Guive Sharifi
Summary: Pituitary adenomas are slow-growing tumors with dysregulation of lncRNAs, including PVT1 and NEAT1, which play important roles in regulating cell functions. In this study, higher expression levels of NEAT1 were found in pituitary adenoma tissues, especially non-functioning pituitary adenoma samples. However, the sensitivity values and AUC values of PVT1 and NEAT1 were not adequate for distinguishing non-functioning pituitary adenomas from non-cancerous tissues.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Bashdar Mahmud Hussen, Mohammad Taheri, Ahmad Eghbali
Summary: LINC00174 is a long intergenic non-coding RNA that plays important roles in human cancer development. It has been shown to have oncogenic effects in various cancers, including colorectal carcinoma, thymic carcinoma, glioma, glioblastoma, hepatocellular carcinoma, kidney renal clear cell carcinoma, breast cancer, and non-functioning pituitary adenoma. However, the role of LINC00174 in lung cancer remains uncertain. This lincRNA is also involved in determining the prognosis of different cancers, particularly colorectal cancer. In this review, we discuss the role of LINC00174 in human carcinogenesis based on available literature and bioinformatics tools.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Hamed Shoorei, Shahram Dabiri Oskuei, Bashdar Mahmud Hussen, Snur Rasool Abdullah, Mohammad Taheri, Elena Jamali
Summary: Toxic agents exist widely in the environment, households, and workplaces. Their contamination in food and drinking water leads to their entry into the body, where they interact with microRNAs (miRNAs), influencing the etiology of various disorders. These agents can alter redox status, release inflammatory cytokines, and affect mitochondrial function. Dysregulation of miRNA expression is implicated in the development of pathological conditions and signaling pathways, while also playing a role in environmental adaptation. Therefore, the interactions between miRNAs and toxic materials contribute to the detrimental effects on human health.
NON-CODING RNA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Mahnaz Zarein, Asghar Zarban, Hamed Shoorei, Mehdi Gharekhani, Mohammadmehdi Hassanzadeh-Taheri
Summary: The study aimed to examine the effects of the antioxidant hesperidin on ovarian damage and toxicity caused by malathion. The results showed that malathion exposure led to abnormalities in ovarian architecture and reduced follicular counts, while hesperidin mitigated the negative effects of malathion on ovarian tissues.
Article
Biochemical Research Methods
Soudeh Ghafouri-Fard, Arian Askari, Alireza Zangooie, Hamed Shoorei, Hasan Pourmoshtagh, Mohammad Taheri
Summary: This review provides a comprehensive examination of the role of different non-coding RNAs in the activity and development of NK cells, highlighting the detrimental effects of dysregulated non-coding RNAs on NK cell function and the potential contribution to diverse disorders.
MOLECULAR AND CELLULAR PROBES
(2023)
