Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*

Autoantibodies Neutralizing Type I Interferons in 20% of COVID-19 Deaths in a French Hospital

(2022) Angélique Chauvineau-Grenier et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Beyond Good and Evil: Molecular Mechanisms of Type I and III IFN Functions

(2022) Jack W. Dowling et al.   JOURNAL OF IMMUNOLOGY

The Battle between Host and SARS-CoV-2: Innate Immunity and Viral Evasion Strategies

(2022) Shilei Zhang et al.   MOLECULAR THERAPY

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

(2022) Jeremy Di Domizio et al.   NATURE

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

(2022) Jennifer E. Huffman et al.   NATURE GENETICS

COVID-19 convalescent plasma composition and immunological effects in severe patients

(2021) Yeny Acosta-Ampudia et al.   JOURNAL OF AUTOIMMUNITY

IFN-α2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2

(2021) Romain Lévy et al.   JOURNAL OF CLINICAL IMMUNOLOGY

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons

(2021) Daxing Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

(2021) Christopher P. Lapointe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

(2021) Can Liu et al.   CELL

SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4

(2021) Fanny Onodi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells

(2021) Antoine Rebendenne et al.   JOURNAL OF VIROLOGY

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

(2021) Sirui Zhou et al.   NATURE MEDICINE

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

(2021) Jing Wu et al.   Cell Reports

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

(2021) Chiara Fallerini et al.   eLife

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

(2021) Jordan J Feld et al.   Lancet Respiratory Medicine

Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients

(2021) Rutger Koning et al.   INTENSIVE CARE MEDICINE

Distinct cytokine profiles associated with COVID-19 severity and mortality

(2021) Karim Dorgham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma

(2021) Sara E. Vazquez et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain

(2021) Jesús Troya et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Interferon-β Therapy in a Patient with Incontinentia Pigmenti and Autoantibodies against Type I IFNs Infected with SARS-CoV-2

(2021) Paul Bastard et al.   JOURNAL OF CLINICAL IMMUNOLOGY

SARS-CoV-2 non-structural protein 1 inhibits the interferon response by causing depletion of key host signaling factors.

(2021) Anil Kumar et al.   JOURNAL OF VIROLOGY

Functional landscape of SARS-CoV-2 cellular restriction

(2021) Laura Martin-Sancho et al.   MOLECULAR CELL

Diverse Functional Autoantibodies in Patients with COVID-19

(2021) Eric Y. Wang et al.   NATURE

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

(2021) Taisho Yamada et al.   NATURE IMMUNOLOGY

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

(2021) Manuel Hayn et al.   Cell Reports

SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression.

(2021) Artem Nemudryi et al.   Cell Reports

SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1

(2021) Liyan Sui et al.   Frontiers in Immunology

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

(2021) GuanQun Liu et al.   Nature Microbiology

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

(2021) Carly G.K. Ziegler et al.   CELL

The interferon landscape along the respiratory tract impacts the severity of COVID-19

(2021) Benedetta Sposito et al.   CELL

SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

(2021) Lucy G Thorne et al.   EMBO JOURNAL

Neutralizing type‐I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID‐19

(2021) Michael S Abers et al.   IMMUNOLOGY AND CELL BIOLOGY

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

(2021) Shuai Wang et al.   NATURE CELL BIOLOGY

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

(2021) Jack Chun-Chieh Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

(2021) Monique G. P. van der Wijst et al.   Science Translational Medicine

Type I Interferon Induction and Exhaustion during Viral Infection: Plasmacytoid Dendritic Cells and Emerging COVID-19 Findings

(2021) Trever T. Greene et al.   Viruses-Basel

SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

(2021) Yongzhen Liu et al.   mBio

New-onset IgG autoantibodies in hospitalized patients with COVID-19

(2021) Sarah Esther Chang et al.   Nature Communications

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

(2021) Maya Shemesh et al.   PLoS Pathogens

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

(2021) Martina Severa et al.   PLoS Pathogens

Endomembrane targeting of human OAS1 p46 augments antiviral activity

(2021) Frank W Soveg et al.   eLife

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

(2021) Xavier Solanich et al.   Frontiers in Immunology

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

(2021) Paul Bastard et al.   Science Immunology

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

(2021) Takaki Asano et al.   Science Immunology

TLR3 and TLR7 RNA Sensor Activation during SARS-COV-2 Infection

(2021) Daria Bortolotti et al.   Microorganisms

Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in COVID-19 Patients

(2021) Elana R Shaw et al.   CLINICAL INFECTIOUS DISEASES

An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19

(2021) Florence Ader et al.   CLINICAL MICROBIOLOGY AND INFECTION

An investigation into the beneficial effects of high-dose interferon beta 1-a, compared to low-dose interferon beta 1-a in severe COVID-19: The COVIFERON II randomized controlled trial

(2021) Ilad Alavi Darazam et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Interferon-α2 Auto-antibodies in Convalescent Plasma Therapy for COVID-19

(2021) Matthijs P. Raadsen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Pre-existing Autoantibodies Neutralizing High Concentrations of Type I Interferons in Almost 10% of COVID-19 Patients Admitted to Intensive Care in Barcelona

(2021) Xavier Solanich et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Evolution of enhanced innate immune evasion by SARS-CoV-2

(2021) Lucy G. Thorne et al.   NATURE

Coronaviral RNA-methyltransferases: function, structure and inhibition

(2021) Radim Nencka et al.   NUCLEIC ACIDS RESEARCH

A prenylated dsRNA sensor protects against severe COVID-19

(2021) Arthur Wickenhagen et al.   SCIENCE

The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression

(2021) Aaron S. Mendez et al.   Cell Reports

Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial

(2021) Andre C Kalil et al.   Lancet Respiratory Medicine

Does SARS‐CoV‐2 has a longer incubation period than SARS and MERS?

(2020) Xuan Jiang et al.   JOURNAL OF MEDICAL VIROLOGY

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

(2020) Stephen A. Lauer et al.   ANNALS OF INTERNAL MEDICINE

Type I IFN immunoprofiling in COVID-19 patients

(2020) Sophie Trouillet-Assant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An 81 nucleotide deletion in SARS-CoV-2 ORF7a identified from sentinel surveillance in Arizona (Jan-Mar 2020)

(2020) LaRinda A. Holland et al.   JOURNAL OF VIROLOGY

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

(2020) Mario Adán Moreno-Eutimio et al.   MICROBES AND INFECTION

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interferon-α2b Treatment for COVID-19

(2020) Qiong Zhou et al.   Frontiers in Immunology

Efficacy and safety of interferon β-1a in treatment of severe COVID-19: A randomized clinical trial

(2020) Effat Davoudi-Monfared et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

(2020) Nan Wang et al.   Cell Host & Microbe

NOD1 and NOD2 in inflammatory and infectious diseases

(2020) Bruno C. Trindade et al.   IMMUNOLOGICAL REVIEWS

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates

(2020) Amin Addetia et al.   JOURNAL OF CLINICAL VIROLOGY

Viral dynamics in mild and severe cases of COVID-19

(2020) Yang Liu et al.   LANCET INFECTIOUS DISEASES

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Structural basis of RNA cap modification by SARS-CoV-2

(2020) Thiruselvam Viswanathan et al.   Nature Communications

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

(2020) Maciej F. Boni et al.   Nature Microbiology

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

(2020) Jeong Seok Lee et al.   Science Immunology

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

Infection and cancer suppress pDC derived IFN-I

(2020) Trever T Greene et al.   CURRENT OPINION IN IMMUNOLOGY

Quantitative and qualitative alterations of circulating myeloid cells and plasmacytoid DC in SARS‐CoV‐2 infection

(2020) Benedetta Peruzzi et al.   IMMUNOLOGY

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

High-resolution structures of the SARS-CoV-2 2′-O-methyltransferase reveal strategies for structure-based inhibitor design

(2020) Monica Rosas-Lemus et al.   Science Signaling

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies

(2020) Mirko Cortese et al.   Cell Host & Microbe

Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

(2020) Shuai Yuan et al.   MOLECULAR CELL

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

(2020) Ioanna-Evdokia Galani et al.   NATURE IMMUNOLOGY

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-α2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities

(2020) Qiong Zhou et al.   Viruses-Basel

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production

(2020) Keli Chen et al.   Viruses-Basel

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

(2020) Steffen Klein et al.   Nature Communications

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.

(2020) Mehdi Moustaqil et al.   Emerging Microbes & Infections

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Phillip D Monk et al.   Lancet Respiratory Medicine

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Severe influenza pneumonitis in children with inherited TLR3 deficiency

(2019) Hye Kyung Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Dual Nature of Type I and Type II Interferons

(2018) Amanda J. Lee et al.   Frontiers in Immunology

Evolution of Interferons and Interferon Receptors

(2017) Chris J. Secombes et al.   Frontiers in Immunology

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference

(2015) Justin K. Taylor et al.   JOURNAL OF VIROLOGY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Elephant shark genome provides unique insights into gnathostome evolution

(2014) Byrappa Venkatesh et al.   NATURE

Antiviral innate immunity and stress granule responses

(2014) Koji Onomoto et al.   TRENDS IN IMMUNOLOGY

Signal Recognition Particle: An Essential Protein-Targeting Machine

(2013) David Akopian et al.   Annual Review of Biochemistry

BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface

(2013) Shiu-Mei Wang et al.   VIROLOGY

Both G3BP1 and G3BP2 contribute to stress granule formation

(2012) Hideaki Matsuki et al.   GENES TO CELLS

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo

(2011) Melissa Swiecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-Stimulated Gene 15 and the Protein ISGylation System

(2010) Dongxian Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Stress granules

(2009) Paul Anderson et al.   CURRENT BIOLOGY

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

(2009) A. R. Stacey et al.   JOURNAL OF VIROLOGY

Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections

(2008) Elina I. Zuniga et al.   Cell Host & Microbe

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE