SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19

(2021) Molly K. Roe et al.   JOURNAL OF GENERAL VIROLOGY

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

(2021) Denis Y Logunov et al.   LANCET

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

(2021) Jing Wu et al.   Cell Reports

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

(2021) Taisho Yamada et al.   NATURE IMMUNOLOGY

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China

(2020) David S. Hui et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study

(2020) Joseph T Wu et al.   LANCET

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis

(2020) Jun Zhao et al.   Cell Metabolism

Weak Induction of Interferon Expression by SARS-CoV-2 Supports Clinical Trials of Interferon Lambda to Treat Early COVID-19

(2020) Thomas R O’Brien et al.   CLINICAL INFECTIOUS DISEASES

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

(2020) Jason D. Goldman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)

(2020) Ruiyun Li et al.   SCIENCE

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

(2020) Qianqian Li et al.   CELL

The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections

(2020) Jatin Machhi et al.   Journal of Neuroimmune Pharmacology

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

(2020) Andrea J. Pruijssers et al.   Cell Reports

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

Mechanisms of SARS-CoV-2 transmission and pathogenesis

(2020) Andrew G. Harrison et al.   TRENDS IN IMMUNOLOGY

Identification of Host Cellular Protein Substrates of SARS-COV-2 Main Protease

(2020) Márió Miczi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

N‐Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS‐CoV‐2 Main Protease

(2020) Tomas Koudelka et al.   PROTEOMICS

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.

(2020) Mehdi Moustaqil et al.   Emerging Microbes & Infections

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

(2018) Wioletta Rut et al.   JOURNAL OF MEDICINAL CHEMISTRY

Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2

(2017) Xinyu Zhu et al.   JOURNAL OF VIROLOGY

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

(2017) Nan Qi et al.   Nature Communications

A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation

(2016) Jun Zhao et al.   Cell Host & Microbe

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

(2016) Miklós Békés et al.   MOLECULAR CELL

Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO

(2015) Dang Wang et al.   JOURNAL OF VIROLOGY

Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production

(2015) Shanping He et al.   MOLECULAR CELL

An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction

(2015) Arlet Minassian et al.   PLoS Pathogens

A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity

(2014) Sky W. Brubaker et al.   CELL

Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2'-O-Methyltransferase Activity

(2014) V. D. Menachery et al.   JOURNAL OF VIROLOGY

Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes

(2014) Dev Bhatt et al.   Frontiers in Immunology

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists

(2013) Yang Yang et al.   Protein & Cell

Murine Gamma Herpesvirus 68 Hijacks MAVS and IKKβ to Abrogate NFκB Activation and Antiviral Cytokine Production

(2011) Xiaonan Dong et al.   PLoS Pathogens

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity

(2010) Oliver Schulz et al.   Cell Host & Microbe

In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

(2010) Mickaël Bouvet et al.   PLoS Pathogens

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

(2008) Kiyohiro Takahasi et al.   MOLECULAR CELL

Kaposi's Sarcoma-Associated Herpesvirus K7 Induces Viral G Protein-Coupled Receptor Degradation and Reduces Its Tumorigenicity

(2008) Hao Feng et al.   PLoS Pathogens