SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.

Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites

(2020) Si Chen et al.   Viruses-Basel

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

An Infectious cDNA Clone of SARS-CoV-2

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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

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Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Porcine Deltacoronavirus nsp5 Cleaves DCP1A to Decrease Its Antiviral Ability

(2020) Xinyu Zhu et al.   JOURNAL OF VIROLOGY

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

(2020) Lucio Verdoni et al.   LANCET

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children

(2020) Francesco Licciardi et al.   PEDIATRICS

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

Artificial intelligence approach fighting COVID-19 with repurposing drugs

(2020) Yi-Yu Ke et al.   Biomedical Journal

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of bats

(2020) Kevin J. Olival et al.   PLoS Pathogens

IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies

(2019) Trine H. Mogensen   Frontiers in Immunology

The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune Responses

(2019) Hao-Sen Chiang et al.   Frontiers in Immunology

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

(2019) Szu-Ting Chen et al.   Cell Host & Microbe

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease

(2019) Aleksandra Antonczyk et al.   Frontiers in Immunology

PathBank: a comprehensive pathway database for model organisms

(2019) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

(2019) Tessa Nelemans et al.   Viruses-Basel

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

(2018) Jian Lei et al.   ANTIVIRAL RESEARCH

Unexpected instabilities explain batch-to-batch variability in cell-free protein expression systems

(2018) Dominic J.B. Hunter et al.   BIOTECHNOLOGY AND BIOENGINEERING

Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC

(2018) Yann Gambin et al.   JOURNAL OF MOLECULAR BIOLOGY

Epigenetic hypomethylation and upregulation of NLRC4 and NLRP12 in Kawasaki disease

(2018) Ying-Hsien Huang et al.   Oncotarget

Structure of a PSI–LHCI–cyt b6f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions

(2018) Janina Steinbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

(2018) Daniela Niemeyer et al.   PLoS Pathogens

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

(2018) Ailís O’Carroll et al.   BMC BIOLOGY

RNA-virus proteases counteracting host innate immunity

(2017) Jian Lei et al.   FEBS LETTERS

Post-Translational Modifications of the TAK1-TAB Complex

(2017) Yusuke Hirata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SARS coronavirus papain-like protease up-regulates the collagen expression through non-Samd TGF-β1 signaling

(2017) Ching-Ying Wang et al.   VIRUS RESEARCH

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure

(2016) Sheryl Coutermarsh-Ott et al.   JOURNAL OF GENERAL VIROLOGY

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

(2016) Miklós Békés et al.   MOLECULAR CELL

Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins

(2016) Baoyu Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

(2016) Yue Ma-Lauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3C Protease of Enterovirus D68 Inhibits Cellular Defense Mediated by Interferon Regulatory Factor 7

(2015) Zichun Xiang et al.   JOURNAL OF VIROLOGY

NLRP12 in autoimmune diseases

(2015) Prajwal Gurung et al.   Oncotarget

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

The multifaceted nature of NLRP12

(2014) Sinem Tuncer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex

(2014) X. Lei et al.   JOURNAL OF VIROLOGY

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

(2014) Krystal Matthews et al.   Virology Journal

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

(2014) Xiaojuan Chen et al.   Protein & Cell

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

(2013) Anna M. Mielech et al.   VIROLOGY

A cell-free approach to accelerate the study of protein-protein interactions in vitro

(2013) E. Sierecki et al.   Interface Focus

TAK1, more than just innate immunity

(2012) Liang Dai et al.   IUBMB LIFE

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation

(2012) Karin Breuer et al.   NUCLEIC ACIDS RESEARCH

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

(2012) Li Sun et al.   PLoS One

PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway

(2011) Gang Wang et al.   PLoS One

Identification and Functional Characterization of Novel Phosphorylation Sites in TAK1-Binding Protein (TAB) 1

(2011) Alexander Wolf et al.   PLoS One

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

(2009) M. Frieman et al.   JOURNAL OF VIROLOGY

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

(2008) Dahai Zheng et al.   CELL RESEARCH

Mutations in NALP12 cause hereditary periodic fever syndromes

(2008) I. Jeru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-β-Activated Protein Kinase 1-Binding Protein (TΑΒ)-1α, But Not ΤΑΒ1β, Mediates Cytokine-Induced p38 Mitogen-Activated Protein Kinase Phosphorylation and Cell Death in Insulin-Producing Cells

(2007) Natalia Makeeva et al.   ENDOCRINOLOGY

SARS coronavirus and innate immunity

(2007) Matthew Frieman et al.   VIRUS RESEARCH