A prenylated dsRNA sensor protects against severe COVID-19

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

(2021) Sirui Zhou et al.   NATURE MEDICINE

A genomic region associated with protection against severe COVID-19 is inherited from Neandertals

(2021) Hugo Zeberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

(2021) Suzannah J. Rihn et al.   PLOS BIOLOGY

Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

(2021) Oscar A. MacLean et al.   PLOS BIOLOGY

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

(2021) Thomas P. Peacock et al.   Nature Microbiology

Mapping the human genetic architecture of COVID-19

(2021)   NATURE

Novel Insights Into Immune Systems of Bats

(2020) Arinjay Banerjee et al.   Frontiers in Immunology

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

(2020) Tran Thi Nhu Thao et al.   NATURE

Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts

(2020) Nardus Mollentze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary structure of the SARS-CoV-2 5’-UTR

(2020) Zhichao Miao et al.   RNA Biology

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19

(2020) Nicholas Parkinson et al.   Scientific Reports

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Phillip D Monk et al.   Lancet Respiratory Medicine

System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection

(2019) Manuel Garcia-Moreno et al.   MOLECULAR CELL

Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates

(2019) Clayton M. Carey et al.   Cell Host & Microbe

TRIM69 Inhibits Vesicular Stomatitis Indiana Virus

(2019) Suzannah J. Rihn et al.   JOURNAL OF VIROLOGY

Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response

(2019) Sneha Rath et al.   MOLECULAR CELL

RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs

(2019) James M. Burke et al.   MOLECULAR CELL

UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity

(2019) Olivia Majer et al.   NATURE

Improved library preparation with the new iCLIP2 protocol

(2019) Andreas Buchbender et al.   METHODS

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

(2019) Saskia Heybrock et al.   Nature Communications

The Cellular Localization of the p42 and p46 Oligoadenylate Synthetase 1 Isoforms and Their Impact on Mitochondrial Respiration

(2019) Stig Skrivergaard et al.   Viruses-Basel

Dampened STING-Dependent Interferon Activation in Bats

(2018) Jiazheng Xie et al.   Cell Host & Microbe

Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20

(2018) Junjie Feng et al.   JOURNAL OF VIROLOGY

The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles

(2018) C. E. Melia et al.   mBio

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry

(2018) Tomas Doyle et al.   Nature Microbiology

TimeTree: A Resource for Timelines, Timetrees, and Divergence Times

(2017) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Host and viral traits predict zoonotic spillover from mammals

(2017) Kevin J. Olival et al.   NATURE

Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy

(2017) Ana Moreno et al.   Virology Journal

Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses

(2017) Andrew E. Shaw et al.   PLOS BIOLOGY

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

(2017) He Li et al.   PLoS Genetics

2′,5′-Oligoadenylate synthetase 1(OAS1) inhibits PRRSV replication in Marc-145 cells

(2016) Jinhua Zhao et al.   ANTIVIRAL RESEARCH

Identification of Interferon-Stimulated Genes with Antiretroviral Activity

(2016) Melissa Kane et al.   Cell Host & Microbe

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity

(2016) Matthew L. Turnbull et al.   JOURNAL OF VIROLOGY

Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L

(2016) Stephen A. Goldstein et al.   JOURNAL OF VIROLOGY

irCLIP platform for efficient characterization of protein–RNA interactions

(2016) Brian J Zarnegar et al.   NATURE METHODS

Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

(2016) Eric L Van Nostrand et al.   NATURE METHODS

Detection and visualization of differential splicing in RNA-Seq data with JunctionSeq

(2016) Stephen W. Hartley et al.   NUCLEIC ACIDS RESEARCH

Virus Variation Resource – improved response to emergent viral outbreaks

(2016) Eneida L. Hatcher et al.   NUCLEIC ACIDS RESEARCH

Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

(2016) Yize Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly

(2016) Inés Romero-Brey et al.   Viruses-Basel

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation

(2016) Joshua M. Thornbrough et al.   mBio

QoRTs: a comprehensive toolset for quality control and data processing of RNA-Seq experiments

(2015) Stephen W. Hartley et al.   BMC BIOINFORMATICS

The Dfam database of repetitive DNA families

(2015) Robert Hubley et al.   NUCLEIC ACIDS RESEARCH

Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China

(2015) Wen Wang et al.   VIROLOGY

Inhibition of the OAS/RNase L pathway by viruses

(2015) Melissa Drappier et al.   Current Opinion in Virology

Discovery of a Novel Coronavirus, China Rattus Coronavirus HKU24, from Norway Rats Supports the Murine Origin of Betacoronavirus 1 and Has Implications for the Ancestor of Betacoronavirus Lineage A

(2015) Susanna K. P. Lau et al.   JOURNAL OF VIROLOGY

Inhibitors of the Interferon Response Enhance Virus Replication In Vitro

(2014) Claire E. Stewart et al.   PLoS One

Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response

(2014) Y. Han et al.   SCIENCE

Murine AKAP7 Has a 2',5'-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene

(2014) E. Gusho et al.   mBio

Middle East Respiratory Syndrome Coronavirus Quasispecies That Include Homologues of Human Isolates Revealed through Whole-Genome Analysis and Virus Cultured from Dromedary Camels in Saudi Arabia

(2014) T. Briese et al.   mBio

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

(2013) Chantal BEM Reusken et al.   LANCET INFECTIOUS DISEASES

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

(2013) Dante Neculai et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

(2013) J. Donovan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity

(2013) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology

(2012) Ling Zhao et al.   Cell Host & Microbe

The ribonucleasel-dependent antiviral roles of human 2′,5′-oligoadenylate synthetase family members against hepatitis C virus

(2012) Young-Chan Kwon et al.   FEBS LETTERS

Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells

(2012) Satoshi Noguchi et al.   HUMAN IMMUNOLOGY

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

(2010) A. Quintas-Cardama et al.   BLOOD

Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy

(2010) Mostafa K El Awady et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

2′-5′-Oligoadenylate synthetase is activated by a specific RNA sequence motif

(2009) Reinhard Kodym et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Scavenger receptor B2 is a cellular receptor for enterovirus 71

(2009) Seiya Yamayoshi et al.   NATURE MEDICINE

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

(2009) Jean K. Lim et al.   PLoS Pathogens

CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215

(2008) Benjamin G. Hale et al.   VIROLOGY

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY