Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Sarbecovirus ORF6 proteins hamper the induction of interferon signaling

(2021) Izumi Kimura et al.   Cell Reports

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Review of trials currently testing treatment and prevention of COVID-19

(2020) Paraskevi C. Fragkou et al.   CLINICAL MICROBIOLOGY AND INFECTION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon beta-1b for COVID-19

(2020) Sarah Shalhoub   LANCET

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing

(2020) Luca Ferretti et al.   SCIENCE

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

(2020) Nan Wang et al.   Cell Host & Microbe

Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics

(2020) Eskild Petersen et al.   LANCET INFECTIOUS DISEASES

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Golgi Apparatus: An Emerging Platform for Innate Immunity

(2020) Ye Tao et al.   TRENDS IN CELL BIOLOGY

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

An improved method for high-throughput quantification of autophagy in mammalian cells

(2020) Lennart Koepke et al.   Scientific Reports

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

(2020) Megan L. Stanifer et al.   Cell Reports

SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts

(2020) Ting Shu et al.   VIROLOGICA SINICA

ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection

(2020) Asmaa Hachim et al.   NATURE IMMUNOLOGY

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2

(2020) Idoia Busnadiego et al.   mBio

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

The antiviral activities of TRIM proteins

(2020) Lennart Koepke et al.   CURRENT OPINION IN MICROBIOLOGY

Autophagy and Inflammation

(2018) Yu Matsuzawa-Ishimoto et al.   Annual Review of Immunology

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

(2018) Jian Lei et al.   ANTIVIRAL RESEARCH

Autophagy during viral infection — a double-edged sword

(2018) Younho Choi et al.   NATURE REVIEWS MICROBIOLOGY

An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses

(2018) Xufang Deng et al.   VIROLOGY

Systematic analysis of protein turnover in primary cells

(2018) Toby Mathieson et al.   Nature Communications

TRIM proteins: New players in virus-induced autophagy

(2018) Konstantin M. J. Sparrer et al.   PLoS Pathogens

TRIM Proteins and Their Roles in Antiviral Host Defenses

(2018) Michiel van Gent et al.   Annual Review of Virology

Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M

(2017) Marianne D. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Bidirectional traffic between the Golgi and the endosomes – machineries and regulation

(2016) Cinzia Progida et al.   JOURNAL OF CELL SCIENCE

SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

(2016) Tomonari Muramatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular detection of viral nucleic acids

(2015) Konstantin MJ Sparrer et al.   CURRENT OPINION IN MICROBIOLOGY

Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1

(2015) Chuan Xia et al.   JOURNAL OF VIROLOGY

Middle East respiratory syndrome

(2015) Alimuddin Zumla et al.   LANCET

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

RIG-I in RNA virus recognition

(2015) Alison M. Kell et al.   VIROLOGY

Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus

(2014) Y. M. Baez-Santos et al.   JOURNAL OF VIROLOGY

Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity

(2013) Christopher C. Stobart et al.   JOURNAL OF VIROLOGY

Organization of the ER–Golgi interface for membrane traffic control

(2013) Federica Brandizzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signaling Organelles of the Innate Immune System

(2012) Jonathan C. Kagan   CELL

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

(2012) Allison L Totura et al.   Current Opinion in Virology

Measles Virus C Protein Interferes with Beta Interferon Transcription in the Nucleus

(2011) K. M. J. Sparrer et al.   JOURNAL OF VIROLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

A Multidisciplinary Therapeutic Approach for Reducing the Risk of Psychiatric Side Effects in Patients With Chronic Hepatitis C Treated With Pegylated Interferon α and Ribavirin

(2010) Sergio Neri et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Measles Virus V Protein Is a Decoy Substrate for I B Kinase   and Prevents Toll-Like Receptor 7/9-Mediated Interferon Induction

(2008) C. K. Pfaller et al.   JOURNAL OF VIROLOGY

SARS coronavirus and innate immunity

(2007) Matthew Frieman et al.   VIRUS RESEARCH