Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

Structure of the RNA specialized translation initiation element that recruits eIF3 to the 5’-UTR of c-Jun

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

The Architecture of SARS-CoV-2 Transcriptome

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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Hepatitis C Virus Translation Regulation

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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tetrapeptide 60–63 of human ribosomal protein uS3 is crucial for translation initiation

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Mechanism of ribosome stalling during translation of a poly(A) tail

(2019) Viswanathan Chandrasekaran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into Structural and Mechanistic Features of Viral IRES Elements

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Efficient and Accurate Translation Initiation Directed by TISU Involves RPS3 and RPS10e Binding and Differential Eukaryotic Initiation Factor 1A Regulation

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Differential analysis of RNA-seq incorporating quantification uncertainty

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cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

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Human eIF3: from ‘blobology’ to biological insight

(2017) Jamie H. D. Cate   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons

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Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation

(2017) Alan G. Hinnebusch   TRENDS IN BIOCHEMICAL SCIENCES

Exploring accessibility of structural elements of the mammalian 40S ribosomal mRNA entry channel at various steps of translation initiation

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eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

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Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Translational control by 5'-untranslated regions of eukaryotic mRNAs

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Structural characterization of ribosome recruitment and translocation by type IV IRES

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A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected Cells

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Molecular contacts of ribose-phosphate backbone of mRNA with human ribosome

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The role of eIF3 and its individual subunits in cancer

(2015) John W.B. Hershey   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes

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Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

(2015) Christopher H S Aylett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

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Structural insights into viral IRES-dependent translation mechanisms

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The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Human Eukaryotic Initiation Factor 2 (eIF2)-GTP-Met-tRNAiTernary Complex and eIF3 Stabilize the 43 S Preinitiation Complex

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Eukaryotic ribosomal protein S3: A constituent of translational machinery and an extraribosomal player in various cellular processes

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The initiation of mammalian protein synthesis and mRNA scanning mechanism

(2013) Ivan B. Lomakin et al.   NATURE

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit

(2013) Yaser Hashem et al.   NATURE

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

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Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

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(2011) Derek Walsh et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism of translation initiation by Dicistroviridae IGR IRESs

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SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

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Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes

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Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

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