ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity

(2020) GuanQun Liu et al.   IMMUNITY

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

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A molecular pore spans the double membrane of the coronavirus replication organelle

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A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions

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The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution

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Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity

(2019) William Riedl et al.   Cell Host & Microbe

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

(2018) Jonny Hertzog et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ISG15 in antiviral immunity and beyond

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Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

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Post-translational Control of Intracellular Pathogen Sensing Pathways

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TRIM23 mediates virus-induced autophagy via activation of TBK1

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Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator

(2016) Berati Cerikan et al.   DEVELOPMENTAL CELL

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

(2016) Miklós Békés et al.   MOLECULAR CELL

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

(2016) Emiko Uchikawa et al.   MOLECULAR CELL

A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity

(2016) Ying Kai Chan et al.   NATURE IMMUNOLOGY

ISG15 deficiency and increased viral resistance in humans but not mice

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Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

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Antagonism of the Phosphatase PP1 by the Measles Virus V Protein Is Required for Innate Immune Escape of MDA5

(2014) Meredith E. Davis et al.   Cell Host & Microbe

Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2'-O-Methyltransferase Activity

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The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

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Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

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Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

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Master sensors of pathogenic RNA – RIG-I like receptors

(2013) Martin Schlee   IMMUNOBIOLOGY

The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection

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Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells

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Conventional Protein Kinase C-  (PKC- ) and PKC-  Negatively Regulate RIG-I Antiviral Signal Transduction

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Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production

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Interferon-Stimulated Gene 15 and the Protein ISGylation System

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Phosphorylation-Mediated Negative Regulation of RIG-I Antiviral Activity

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Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

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Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

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Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

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