MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage

(2022) Karla F. Meza-Sosa et al.   MOLECULAR CELL

CARM1 regulates replication fork speed and stress response by stimulating PARP1

(2021) Marie-Michelle Genois et al.   MOLECULAR CELL

The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells

(2021) Antoine Simoneau et al.   GENES & DEVELOPMENT

Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

(2021) Michaela Ihle et al.   NUCLEIC ACIDS RESEARCH

Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

(2021) Mariana Paes Dias et al.   MOLECULAR CELL

Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells

(2021) Stephanie Tirman et al.   MOLECULAR CELL

Mdm2 – open questions

(2020) Matthias Dobbelstein et al.   CANCER SCIENCE

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

(2020) Gongshi Bai et al.   MOLECULAR CELL

Mdm4 supports DNA replication in a p53-independent fashion

(2020) Kai Wohlberedt et al.   ONCOGENE

Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy

(2020) Annika Krüger et al.   Nature Communications

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line

(2020) Masaki Kobayashi et al.   Oncotarget

The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

(2020) Matteo Berti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

(2020) Marco Gatti et al.   Cell Reports

RECQ1 Helicase in Genomic Stability and Cancer

(2020) Subrata Debnath et al.   Genes

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of replication fork speed: Mechanisms and impact on genomic stability

(2019) Joanna Maria Merchut-Maya et al.   DNA REPAIR

PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

(2019) Annabel Quinet et al.   MOLECULAR CELL

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

(2019) Nagaraja Chappidi et al.   MOLECULAR CELL

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

(2018) Glen Liszczak et al.   Nature Chemical Biology

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

(2018) Stephen J. Pettitt et al.   Nature Communications

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

(2018) Sunetra Roy et al.   eLife

Serine is the major residue for ADP-ribosylation upon DNA damage

(2018) Luca Palazzo et al.   eLife

Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

(2018) Jonas Andreas Schmid et al.   MOLECULAR CELL

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

(2018) Qian Chen et al.   Nature Communications

Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation

(2018) Sara C. Larsen et al.   Cell Reports

Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression

(2018) Yangbing Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

(2018) Ina Klusmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Roles of E3 Ubiquitin Ligases in p53 Regulation

(2017) Sanam Sane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Replication Fork Reversal: Players and Guardians

(2017) Annabel Quinet et al.   MOLECULAR CELL

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PrimPol—Prime Time to Reprime

(2017) Thomas Guilliam et al.   Genes

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

(2016) Ian Gibbs-Seymour et al.   MOLECULAR CELL

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

(2016) Magdalena Wienken et al.   MOLECULAR CELL

DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression

(2016) Stephanie Hampp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mdm2 as a chromatin modifier

(2016) Magdalena Wienken et al.   Journal of Molecular Cell Biology

Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer

(2016) Haoran Bi et al.   Scientific Reports

p53 Activity Results in DNA Replication Fork Processivity

(2016) Ina Klusmann et al.   Cell Reports

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

(2016) Constance Qiao Xin Yeo et al.   Cell Reports

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf–Mdm2–p53 and RP–Mdm2–p53 pathways

(2015) X Meng et al.   ONCOGENE

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

(2015) María Belén Vallerga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53

(2014) Ivanildce Cristiane Ireno et al.   CARCINOGENESIS

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

(2014) Marie-France Langelier et al.   NUCLEIC ACIDS RESEARCH

Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

(2013) Stephanie Jungmichel et al.   MOLECULAR CELL

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

(2013) Cindy Follonier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MDM2’s social network

(2013) R Fåhraeus et al.   ONCOGENE

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

(2013) F. Kopper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond

(2013) Lidiya Luzhna et al.   Frontiers in Genetics

Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds

(2012) Wataru Nagai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation

(2012) Lisa Kashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts

(2011) Shingo Matsushima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

(2011) Thomas Helleday   Molecular Oncology

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

(2011) H. C. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

(2009) Sandie Tuduri et al.   NATURE CELL BIOLOGY