The multiple mechanisms that regulate p53 activity and cell fate

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest

(2018) José Reyes et al.   MOLECULAR CELL

Revealing a human p53 universe

(2018) Thuy-Ai T Nguyen et al.   NUCLEIC ACIDS RESEARCH

The young and the restless

(2017) Elie Dolgin   NATURE

p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics

(2017) Antonina Hafner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p53 regulates enhancer accessibility and activity in response to DNA damage

(2017) Scott T. Younger et al.   NUCLEIC ACIDS RESEARCH

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics

(2017) Antonina Hafner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing

(2016) Andrew L. Paek et al.   CELL

p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis

(2016) Nicholas W. Fischer et al.   CELL CYCLE

Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic

(2016) Annelien Verfaillie et al.   GENOME RESEARCH

Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode

(2016) Radion Vainer et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9

(2016) Gozde Korkmaz et al.   NATURE BIOTECHNOLOGY

Enhancers as non-coding RNA transcription units: recent insights and future perspectives

(2016) Wenbo Li et al.   NATURE REVIEWS GENETICS

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

(2016) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein

(2016) Oleg Laptenko et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Paradox of p53: What, How, and Why?

(2016) Yael Aylon et al.   Cold Spring Harbor Perspectives in Medicine

p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks

(2016) Joshua R. Porter et al.   Cell Systems

Whole-genome cartography of p53 response elements ranked on transactivation potential

(2015) Toma Tebaldi et al.   BMC GENOMICS

The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain

(2015) Oleg Laptenko et al.   MOLECULAR CELL

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

(2015) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53

(2015) A Desantis et al.   Cell Death & Disease

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

(2015) Claudia Tonelli et al.   Oncotarget

Understanding the non-canonical pathways involved in p53-mediated tumor suppression

(2014) K. M. Hager et al.   CARCINOGENESIS

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

(2014) Ramiro París et al.   CELL CYCLE

The transcription factor p53: Not a repressor, solely an activator

(2014) Martin Fischer et al.   CELL CYCLE

Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis

(2014) H Li et al.   CELL DEATH AND DIFFERENTIATION

TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity

(2014) Morgan A. Sammons et al.   GENOME RESEARCH

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

(2014) S. S. McDade et al.   NUCLEIC ACIDS RESEARCH

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

(2014) Jayne Loughery et al.   NUCLEIC ACIDS RESEARCH

Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation

(2014) S. Rashi-Elkeles et al.   Science Signaling

A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress

(2014) Gue Su Chang et al.   Cell Reports

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

(2014) Mary Ann Allen et al.   eLife

SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

(2013) Zhanyun Tang et al.   CELL

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

(2013) P.-J. Hamard et al.   GENES & DEVELOPMENT

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53

(2013) Caroline J. DeHart et al.   MOLECULAR & CELLULAR PROTEOMICS

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells

(2013) Kadir C. Akdemir et al.   NUCLEIC ACIDS RESEARCH

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

Activation and control of p53 tetramerization in individual living cells

(2013) G. Gaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes

(2013) Iva Simeonova et al.   Cell Reports

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

(2013) Oleg Timofeev et al.   Cell Reports

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

(2013) Katharina Schlereth et al.   PLoS Genetics

The impact of post-transcriptional regulation in the p53 network

(2012) J. A. Freeman et al.   Briefings in Functional Genomics

Distinct p53 genomic binding patterns in normal and cancer-derived human cells

(2012) Krassimira Botcheva et al.   CELL CYCLE

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

(2012) Marianne Quaas et al.   CELL CYCLE

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

(2012) Katja Höpker et al.   EMBO JOURNAL

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

(2012) O. Aksoy et al.   GENES & DEVELOPMENT

p53 Basic C Terminus Regulates p53 Functions through DNA Binding Modulation of Subset of Target Genes

(2012) Pierre-Jacques Hamard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

(2012) X. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells

(2012) Mangmang Li et al.   MOLECULAR CELL

eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

(2012) Carlos A. Melo et al.   MOLECULAR CELL

p53 Dimers Associate with a Head-to-Tail Response Element to Repress Cyclin B Transcription

(2012) Robert Lipski et al.   PLoS One

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

The p53 response element and transcriptional repression

(2011) Bei Wang et al.   CELL CYCLE

p53 Requires an Intact C-Terminal Domain for DNA Binding and Transactivation

(2011) Hyunjung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

p53-Dependent Transcription and Tumor Suppression Are Not Affected in Set7/9-Deficient Mice

(2011) Bernhard Lehnertz et al.   MOLECULAR CELL

The Methyltransferase Set7/9 (Setd7) Is Dispensable for the p53-Mediated DNA Damage Response In Vivo

(2011) Stefano Campaner et al.   MOLECULAR CELL

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

(2011) Bart Westendorp et al.   NUCLEIC ACIDS RESEARCH

Crosstalk between c-Jun and TAp73α/β contributes to the apoptosis–survival balance

(2011) Max Koeppel et al.   NUCLEIC ACIDS RESEARCH

Role of p53 Serine 46 in p53 Target Gene Regulation

(2011) Leonie Smeenk et al.   PLoS One

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90

(2011) C. Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

(2011) E. Arbely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation

(2011) O. Laptenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of mRNA decay in p53-induced gene expression

(2011) B. D. Melanson et al.   RNA

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy

(2010) E. Lidor Nili et al.   GENOME RESEARCH

The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression

(2010) Lisandra E. West et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

(2010) Katharina Schlereth et al.   MOLECULAR CELL

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

(2010) Malka Kitayner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

(2010) Itai Beno et al.   NUCLEIC ACIDS RESEARCH

A single-molecule characterization of p53 search on DNA

(2010) A. Tafvizi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of transcriptional activity of p53 in individual living mammalian cells

(2009) Toshiaki Imagawa et al.   ANALYTICAL BIOCHEMISTRY

The p53HMM algorithm: using profile hidden markov models to detect p53-responsive genes

(2009) Todd Riley et al.   BMC BIOINFORMATICS

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

(2009) Tobias Brandt et al.   BMC GENOMICS

B-MYB Is Required for Recovery from the DNA Damage-Induced G2 Checkpoint in p53 Mutant Cells

(2009) M. Mannefeld et al.   CANCER RESEARCH

Redefining the p53 response element

(2009) B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the Functional Impact of Sequence Variation on p53-DNA Interactions Using a Novel Microsphere Assay for Protein-DNA Binding with Human Cell Extracts

(2009) Maher A. Noureddine et al.   PLoS Genetics

Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability

(2008) Anahita Tafvizi et al.   BIOPHYSICAL JOURNAL

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Role for 53BP1 Tudor Domain Recognition of p53 Dimethylated at Lysine 382 in DNA Damage Signaling

(2008) Ioulia Kachirskaia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of genome-wide p53-binding sites upon stress response

(2008) Leonie Smeenk et al.   NUCLEIC ACIDS RESEARCH

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

(2008) S. Patel et al.   NUCLEIC ACIDS RESEARCH

Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA

(2008) Dmitry B. Veprintsev et al.   NUCLEIC ACIDS RESEARCH

Biochemical and Structural Studies of ASPP Proteins Reveal Differential Binding to p53, p63, and p73

(2008) Ross Alexander Robinson et al.   STRUCTURE