Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

(2020) Gongshi Bai et al.   MOLECULAR CELL

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

(2020) Sabrina Florencia Mansilla et al.   Genes

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

(2020) Sumeet Nayak et al.   Science Advances

A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation

(2020) Cara B. Eldridge et al.   Stem Cell Reports

RNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools

(2019) Alice Meroni et al.   NUCLEIC ACIDS RESEARCH

Role of Y-family Translesion DNA Polymerases in Replication Stress: Implications for New Cancer Therapeutic Targets

(2019) Peter Tonzi et al.   DNA REPAIR

DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy

(2019) Bas Pilzecker et al.   NUCLEIC ACIDS RESEARCH

Polymerase iota - an odd sibling among Y family polymerases

(2019) Justyna McIntyre   DNA REPAIR

Electrophysiological investigation of human embryonic stem cell derived neurospheres using a novel spike detection algorithm

(2018) Margot Mayer et al.   BIOSENSORS & BIOELECTRONICS

Ribonucleotide discrimination by translesion synthesis DNA polymerases

(2018) Alexandra Vaisman et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress

(2018) Joonyoung Her et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

(2018) Sunetra Roy et al.   eLife

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53

(2018) Vanesa Gottifredi et al.   Cancers

53BP1: A key player of DNA damage response with critical functions in cancer

(2018) Mohammad Mirza-Aghazadeh-Attari et al.   DNA REPAIR

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

(2018) Ina Klusmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Base excision repair proteins couple activation-induced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization

(2017) B Gole et al.   LEUKEMIA

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

(2017) Marko Vujanovic et al.   MOLECULAR CELL

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

Ionizing Radiation Alters Human Embryonic Stem Cell Properties and Differentiation Capacity by Diminishing the Expression of Activin Receptors

(2017) Sabine Luft et al.   STEM CELLS AND DEVELOPMENT

Structural insights into the function of ZRANB3 in replication stress response

(2017) Marek Sebesta et al.   Nature Communications

Ensa controls S-phase length by modulating Treslin levels

(2017) Sophie Charrasse et al.   Nature Communications

Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification

(2017) Svetlana Petruk et al.   Cell Reports

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

(2016) Magdalena Wienken et al.   MOLECULAR CELL

DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression

(2016) Stephanie Hampp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

(2016) Akshay K. Ahuja et al.   Nature Communications

The histone variant H2A.X is a regulator of the epithelial–mesenchymal transition

(2016) Urbain Weyemi et al.   Nature Communications

p53 Activity Results in DNA Replication Fork Processivity

(2016) Ina Klusmann et al.   Cell Reports

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

(2016) Constance Qiao Xin Yeo et al.   Cell Reports

Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage

(2016) Hervé Técher et al.   Cell Reports

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation

(2016) Arnold J. Levine et al.   Cold Spring Harbor Perspectives in Medicine

Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

(2016) Sabrina F Mansilla et al.   eLife

Mapping gene regulatory circuitry of Pax6 during neurogenesis

(2016) Sudhir Thakurela et al.   Cell Discovery

The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight

(2015) A.P. Bertolin et al.   DNA REPAIR

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4

(2015) M Pieraccioli et al.   ONCOGENE

p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3

(2015) Sabine Hünten et al.   Oncotarget

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53

(2014) Ivanildce Cristiane Ireno et al.   CARCINOGENESIS

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

(2013) K. J. Neelsen et al.   GENES & DEVELOPMENT

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

(2013) S. F. Mansilla et al.   NUCLEIC ACIDS RESEARCH

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

(2013) J. E. Sale   Cold Spring Harbor Perspectives in Biology

Substrate-Selective Repair and Restart of Replication Forks by DNA Translocases

(2013) Rémy Bétous et al.   Cell Reports

Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

(2013) Bunsyo Shiotani et al.   Cell Reports

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

Ovarian carcinoma tumor-initiating cells have a mesenchymal phenotype

(2012) Francesca Ricci et al.   CELL CYCLE

Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling

(2012) Dung-Fang Lee et al.   Cell Stem Cell

Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress

(2012) Alberto Ciccia et al.   MOLECULAR CELL

The role of DNA repair in the pluripotency and differentiation of human stem cells

(2012) Clarissa Ribeiro Reily Rocha et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA

(2012) J. Speroni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells

(2012) Abhinav K. Jain et al.   PLOS BIOLOGY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation

(2011) Yong-Sam Jung et al.   DNA REPAIR

SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis

(2011) Jia-Ren Lin et al.   MOLECULAR CELL

Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells

(2010) Hiroyuki Niida et al.   CANCER SCIENCE

Stem Cells and DNA Damage: Persist or Perish?

(2010) Andrew A. Lane et al.   CELL

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

(2010) Michael Milyavsky et al.   Cell Stem Cell

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

(2010) Mary E. Gagou et al.   MOLECULAR BIOLOGY OF THE CELL

Chk1 promotes replication fork progression by controlling replication initiation

(2010) E. Petermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

(2008) C.A. Bañuelos et al.   DNA REPAIR