Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy

Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy

(2019) Annika Krüger et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation

(2018) Gabriella Zarkovic et al.   NUCLEIC ACIDS RESEARCH

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

(2018) Marie-France Langelier et al.   Nature Communications

Dna is a New Target of Parp3

(2018) E. A. Belousova et al.   Scientific Reports

The comings and goings of PARP-1 in response to DNA damage

(2018) John M. Pascal   DNA REPAIR

Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism

(2018) Johannes Rudolph et al.   eLife

PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification

(2018) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Reversible mono-ADP-ribosylation of DNA breaks

(2017) Deeksha Munnur et al.   FEBS Journal

Serine ADP-Ribosylation Depends on HPF1

(2017) Juan José Bonfiglio et al.   MOLECULAR CELL

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

(2017) Lili Liu et al.   NUCLEIC ACIDS RESEARCH

The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1

(2017) Arthur Fischbach et al.   NUCLEIC ACIDS RESEARCH

The role of poly ADP-ribosylation in the first wave of DNA damage response

(2017) Chao Liu et al.   NUCLEIC ACIDS RESEARCH

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

(2016) Ian Gibbs-Seymour et al.   MOLECULAR CELL

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

(2016) Jamin D. Steffen et al.   NUCLEIC ACIDS RESEARCH

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

(2016) B. A. Gibson et al.   SCIENCE

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Functions of PARylation in DNA Damage Repair Pathways

(2016) Huiting Wei et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

(2015) T. A. Hopkins et al.   MOLECULAR CANCER RESEARCH

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation

(2015) Eva Barkauskaite et al.   MOLECULAR CELL

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

(2015) Sebastian Eustermann et al.   MOLECULAR CELL

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

(2015) Jennine M. Dawicki-McKenna et al.   MOLECULAR CELL

Obtaining information about protein secondary structures in aqueous solution using Fourier transform IR spectroscopy

(2015) Huayan Yang et al.   Nature Protocols

Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging

(2015) Maria V. Sukhanova et al.   NUCLEIC ACIDS RESEARCH

Chain-Terminating and Clickable NAD+Analogues for Labeling the Target Proteins of ADP-Ribosyltransferases

(2014) Yan Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

(2014) Marie-France Langelier et al.   NUCLEIC ACIDS RESEARCH

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

(2013) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

(2013) Tobias Karlberg et al.   MOLECULAR ASPECTS OF MEDICINE

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

(2013) J. Murai et al.   MOLECULAR CANCER THERAPEUTICS

Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

(2013) Stephanie Jungmichel et al.   MOLECULAR CELL

Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome

(2013) Yajie Zhang et al.   NATURE METHODS

Structural Implications for Selective Targeting of PARPs

(2013) Jamin D. Steffen et al.   Frontiers in Oncology

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

(2012) Ammar A E Ali et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

(2011) Sebastian Eustermann et al.   JOURNAL OF MOLECULAR BIOLOGY

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

(2011) Michael Weinfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural studies of the PARP-1 BRCT domain

(2011) Paul A Loeffler et al.   BMC STRUCTURAL BIOLOGY

The Zn3 Domain of Human Poly(ADP-ribose) Polymerase-1 (PARP-1) Functions in Both DNA-dependent Poly(ADP-ribose) Synthesis Activity and Chromatin Compaction

(2010) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span

(2010) Sascha Beneke et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Structural and Biophysical Studies of Human PARP-1 in Complex with Damaged DNA

(2009) Wayne Lilyestrom et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

(2008) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH