Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells

To skip or not to skip: choosing repriming to tolerate DNA damage

(2021) Annabel Quinet et al.   MOLECULAR CELL

PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks

(2021) Daniel González‐Acosta et al.   EMBO JOURNAL

The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells

(2021) Antoine Simoneau et al.   GENES & DEVELOPMENT

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

(2021) Ke Cong et al.   MOLECULAR CELL

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

(2020) Gongshi Bai et al.   MOLECULAR CELL

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

(2020) Tanay Thakar et al.   Nature Communications

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

(2020) Sumeet Nayak et al.   Science Advances

TDP-43 dysfunction results in R-loop accumulation and DNA replication defects

(2020) Matthew Wood et al.   JOURNAL OF CELL SCIENCE

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

(2020) Ann Liza Piberger et al.   Nature Communications

Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation

(2019) Eva Malacaria et al.   Nature Communications

Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates

(2019) David Gallo et al.   MOLECULAR CELL

PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers

(2019) Patrick G. Pilié et al.   CLINICAL CANCER RESEARCH

The invariant glutamate of human PrimPol DxE motif is critical for its Mn2+-dependent distinctive activities

(2019) Patricia A. Calvo et al.   DNA REPAIR

A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy

(2019) Jessica L. Wojtaszek et al.   CELL

Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathways

(2019) Yuji Masuda et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

(2019) Annabel Quinet et al.   MOLECULAR CELL

Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

(2018) Alan Ashworth et al.   Nature Reviews Clinical Oncology

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing

(2018) Denisse Carvajal-Maldonado et al.   NUCLEIC ACIDS RESEARCH

Break-Induced Replication: The Where, The Why, and The How

(2018) J. Kramara et al.   TRENDS IN GENETICS

Mechanisms of PARP inhibitor sensitivity and resistance

(2018) Alan D. D’Andrea   DNA REPAIR

R‐loop formation during S phase is restricted by PrimPol‐mediated repriming

(2018) Saša Šviković et al.   EMBO JOURNAL

USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors

(2018) Kah Suan Lim et al.   MOLECULAR CELL

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

(2017) Stephanie A. Yazinski et al.   GENES & DEVELOPMENT

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

(2016) Kaori Kobayashi et al.   CELL CYCLE

DNA damage tolerance by recombination: Molecular pathways and DNA structures

(2016) Dana Branzei et al.   DNA REPAIR

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

(2016) Davide Schiavone et al.   MOLECULAR CELL

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells

(2016) Annabel Quinet et al.   NUCLEIC ACIDS RESEARCH

Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations

(2016) Markus Christmann et al.   NUCLEIC ACIDS RESEARCH

A novel splice site mutation inSMARCAL1results in aberrant exon definition in a child with schimke immunoosseous dysplasia

(2015) Clinton Carroll et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex

(2015) Marco Fumasoni et al.   MOLECULAR CELL

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

(2015) Anderson T. Wang et al.   MOLECULAR CELL

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

(2015) María Belén Vallerga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Proliferation: Keep Dividing and Don't Mind the Gap

(2015) Luisa Laureti et al.   PLoS Genetics

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome

(2014) Annabel Quinet et al.   DNA REPAIR

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

(2014) V. Gonzalez-Huici et al.   EMBO JOURNAL

Human PrimPol mutation associated with high myopia has a DNA replication defect

(2014) Benjamin A. Keen et al.   NUCLEIC ACIDS RESEARCH

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

(2013) Li Wan et al.   EMBO REPORTS

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

(2013) F. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome

(2012) Piya Temviriyanukul et al.   DNA REPAIR

Noncanonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway

(2012) Georgios Ioannis Karras et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells

(2012) J.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening

(2011) Fei Huang et al.   ACS Chemical Biology

UV stalled replication forks restart by re-priming in human fibroblasts

(2011) Ingegerd Elvers et al.   NUCLEIC ACIDS RESEARCH

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

(2011) Noam Diamant et al.   NUCLEIC ACIDS RESEARCH

REV1 and polymerase ζ facilitate homologous recombination repair

(2011) Shilpy Sharma et al.   NUCLEIC ACIDS RESEARCH

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase

(2010) Georgios I. Karras et al.   CELL

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch

(2010) Fabio Vanoli et al.   PLoS Genetics

Mammalian polymerase ζ is essential for post-replication repair of UV-induced DNA lesions

(2009) Jacob G. Jansen et al.   DNA REPAIR

Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5

(2009) Joanne L Parker et al.   EMBO JOURNAL

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

(2009) Sigal Shachar et al.   EMBO JOURNAL

Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

(2009) J. K. Hicks et al.   MOLECULAR AND CELLULAR BIOLOGY

Repair of gaps opposite lesions by homologous recombination in mammalian cells

(2009) S. Adar et al.   NUCLEIC ACIDS RESEARCH

Enhancing the efficacy of cisplatin in ovarian cancer treatment – could arsenic have a role

(2009) C William Helm et al.   Journal of Ovarian Research

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

(2008) Charlotte E. Edmunds et al.   MOLECULAR CELL

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology