PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

(2014) Carole Beck et al.   NUCLEIC ACIDS RESEARCH

Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer

(2013) J. D. Steffen et al.   CANCER RESEARCH

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

(2013) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

(2013) Reza Sharifi et al.   EMBO JOURNAL

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

(2012) Mike De Vos et al.   BIOCHEMICAL PHARMACOLOGY

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

(2011) Sebastian Eustermann et al.   JOURNAL OF MOLECULAR BIOLOGY

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

(2011) C. Boehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

(2010) Maxim Isabelle et al.   Proteome Science

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Identification of the ADP-Ribosylation Sites in the PARP-1 Automodification Domain: Analysis and Implications

(2009) Zhihua Tao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

(2009) Matthias Altmeyer et al.   NUCLEIC ACIDS RESEARCH

Substrate-Assisted Catalysis by PARP10 Limits Its Activity to Mono-ADP-Ribosylation

(2008) Henning Kleine et al.   MOLECULAR CELL

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE