Trehalose against Alzheimer's Disease: Insights into a Potential Therapy

Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease

(2019) Masoomeh Khalifeh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trehalase localization in the cerebral cortex, hippocampus and cerebellum of mouse brains

(2019) L. Halbe et al.   Journal of Advanced Research

Interactions between amyloid β peptide and lipid membranes

(2018) Zheng Niu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts

(2018) Kiana Hosseinpour-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Drug development for Alzheimer’s disease: review

(2018) Kejing Lao et al.   JOURNAL OF DRUG TARGETING

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

(2018) Karolina Pierzynowska et al.   METABOLIC BRAIN DISEASE

Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide

(2018) J. Folch et al.   NEUROLOGIA

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction

(2018) He-Jin Lee et al.   Cell Death & Disease

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease

(2017) Stuart D. Portbury et al.   JOURNAL OF ALZHEIMERS DISEASE

Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice

(2017) Michael J. Pagliassotti et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Trehalose induced conformational changes in the amyloid-β peptide

(2017) Shagufta H. Khan et al.   PATHOLOGY RESEARCH AND PRACTICE

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity

(2016) Alessandro Sinopoli et al.   CHEMBIOCHEM

Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein

(2016) Nguyen T. Tien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

(2016) Valeria D. Felice et al.   PARKINSONISM & RELATED DISORDERS

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation

(2016) Valentina Oliveri et al.   RSC Advances

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway

(2016) Xu Chen et al.   Scientific Reports

SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy

(2016) Allyson L. Mayer et al.   Scientific Reports

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease

(2015) Kunikazu Tanji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advances in Alzheimer’s Disease Drug Development

(2015) Michael S Rafii et al.   BMC Medicine

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer’s disease

(2015) Yuyou Zhu et al.   NEUROLOGICAL SCIENCES

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis

(2014) Xiaojie Zhang et al.   Autophagy

‘Click’ assembly of glycoclusters and discovery of a trehalose analogue that retards Aβ40 aggregation and inhibits Aβ40-induced neurotoxicity

(2014) Hemalatha Rajaram et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

(2014) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors

(2014) Guilherme Monteiro Gomes et al.   PLoS One

Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia

(2014) Maria Jose Casarejos et al.   PLoS One

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Probing the interplay between amyloidogenic proteins and membranes using lipid monolayers and bilayers

(2013) Annalisa Relini et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice

(2013) Jing Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Insights into the mechanism of interaction between trehalose-conjugated beta-sheet breaker peptides and Aβ(1–42) fibrils by molecular dynamics simulations

(2013) Ida Autiero et al.   Molecular BioSystems

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy

(2013) Paola Rusmini et al.   NEUROBIOLOGY OF AGING

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease

(2013) Fernando J. Sepúlveda et al.   NEUROBIOLOGY OF AGING

β-Secretase: its biology as a therapeutic target in diseases

(2013) Haibo Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils

(2012) Wen-Bo Yu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Soluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response

(2012) Yan He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

Amyloid-β Immunotherapy for Alzheimers Disease

(2012) H.J. Fu et al.   CNS & Neurological Disorders-Drug Targets

Trehalose Protects from Aggravation of Amyloid Pathology Induced by Isoflurane Anesthesia in APPswe Mutant Mice

(2012) Juan Perucho et al.   Current Alzheimer Research

Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-d-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology

(2012) Laura Connelly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage

(2012) Ryosuke Echigo et al.   Journal of Translational Medicine

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein

(2012) Dan-Mei Lan et al.   NEUROCHEMICAL RESEARCH

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells

(2011) M.J. Casarejos et al.   NEUROCHEMISTRY INTERNATIONAL

Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers

(2010) Aslin Izmitli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Anti-aggregation properties of trehalose on heat-induced secondary structure and conformation changes of bovine serum albumin

(2010) Davide Barreca et al.   BIOPHYSICAL CHEMISTRY

Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity

(2010) Massimo Stefani   FEBS Journal

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Novel insights for the treatment of Alzheimer's disease

(2010) Alexander Kurz et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Neuropathology and therapeutic management of Alzheimer's disease - An update

(2009) A. Kumar et al.   DRUGS OF THE FUTURE

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Effect of trehalose on amyloid β (29–40)-membrane interaction

(2009) Allam S. Reddy et al.   JOURNAL OF CHEMICAL PHYSICS

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Aβ(1-42) fibrillogenesis and toxicity

(2009) Paolo De Bona et al.   JOURNAL OF PEPTIDE SCIENCE

Molecular Insight into the Inhibition Effect of Trehalose on the Nucleation and Elongation of Amyloid β-Peptide Oligomers

(2009) Fu-Feng Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effect of Trehalose on W7FW14F Apomyoglobin and Insulin Fibrillization:  New Insight into Inhibition Activity†

(2008) Silvia Vilasi et al.   BIOCHEMISTRY

Trehalose: A biophysics approach to modulate the inflammatory response during endotoxic shock

(2008) Letteria Minutoli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amyloid-β Membrane Binding and Permeabilization are Distinct Processes Influenced Separately by Membrane Charge and Fluidity

(2008) Pamela T. Wong et al.   JOURNAL OF MOLECULAR BIOLOGY

Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-β peptide

(2008) Eva Y. Chi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose

(2008) Yoshiko Miura et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS