A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

Published 2019 View Full Article

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Title
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
Authors
Keywords
Alzheimer’s disease, amyloid-beta, Aβ, presenilin, endocytosis, beta-C-terminal fragment, β-CTF, induced pluripotent stem cell, amyloid precursor protein, CRISPR/Cas9, Rab5
Journal
NEURON
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2019-08-12
DOI
10.1016/j.neuron.2019.07.010

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