Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum

Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3β pathway in cells and in APP/PS1 transgenic mice

(2018) Xiaomin Yin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2,3,4′,5-tetrahydroxystilbene-2-O-β-d-glycoside attenuates atherosclerosis in apolipoprotein E-deficient mice: role of reverse cholesterol transport

(2018) Xuemeng Chen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Tetrahydroxystilbene Glucoside Delayed Senile Symptoms in Old Mice via Regulation of the AMPK/SIRT1/PGC-1α Signaling Cascade

(2018) Zhaochen Ning et al.   GERONTOLOGY

Anti-amyloidgenic and neurotrophic effects of tetrahydroxystilbene glucoside on a chronic mitochondrial dysfunction rat model induced by sodium azide

(2018) Ru-yi Zhang et al.   Journal of Natural Medicines

Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss

(2018) Yanzhen Zhou et al.   Journal of Neuroinflammation

Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression

(2018) Chenli Jiao et al.   NEUROREPORT

Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity

(2018) Chun Huang et al.   Oxidative Medicine and Cellular Longevity

Cognitive enhancing and antioxidant effects of tetrahydroxystilbene glucoside in A β 1 - 42 -induced neurodegeneration in mice

(2017) Miao Xie et al.   Journal of Integrative Neuroscience

Potential molecular mechanisms mediating the protective effects of tetrahydroxystilbene glucoside on MPP+-induced PC12 cell apoptosis

(2017) Lingling Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Tetrahydroxy stilbene glucoside ameliorates H2O2-induced human brain microvascular endothelial cell dysfunction in vitro by inhibiting oxidative stress and inflammatory responses

(2017) Zhao Jiang et al.   Molecular Medicine Reports

HO-1 Is Essential for Tetrahydroxystilbene Glucoside Mediated Mitochondrial Biogenesis and Anti-Inflammation Process in LPS-Treated RAW264.7 Macrophages

(2017) Weihua Yu et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Modulation of Protein Expression in parkin-Mutant Human Skin Fibroblasts: A Proteomic Approach

(2017) Daniele Vergara et al.   Oxidative Medicine and Cellular Longevity

PPAR-γ is involved in the protective effect of 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside against cardiac fibrosis in pressure-overloaded rats

(2016) Yi Peng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

2,3,4′,5-tetrahydroxystilbene-2-O-β-d-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-κB and activating AMPK/Nrf2 pathways

(2016) Sun Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Tetrahydroxystilbene Glucoside Exerts Cytoprotective Effect against Hydrogen Peroxide-induced Cell Death Involving ROS Production and Antioxidant Enzyme Activation

(2016) S S Tian et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Promotes Expression of the Longevity Gene Klotho

(2016) Shuang Ling et al.   Oxidative Medicine and Cellular Longevity

Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

(2016) Shuang Ling et al.   Oxidative Medicine and Cellular Longevity

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside Attenuates Ischemia/Reperfusion-Induced Brain Injury in Rats by Promoting Angiogenesis

(2016) Ying Mu et al.   PLANTA MEDICA

High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma

(2015) Xuelian Cui et al.   BMC CANCER

Protective effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside in the MPTP-induced mouse model of Parkinson's disease: Involvement of reactive oxygen species-mediated JNK, P38 and mitochondrial pathways

(2015) Hong He et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TSG attenuates LPC-induced endothelial cells inflammatory damage through notch signaling inhibition

(2015) Jing Zhao et al.   IUBMB LIFE

Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1

(2015) Xuanxuan Zhou et al.   NEUROBIOLOGY OF AGING

TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese HerbPolygonum multiflorumIncreases Life Span and Stress Resistance ofCaenorhabditis elegans

(2015) Christian Büchter et al.   Oxidative Medicine and Cellular Longevity

Tetrahydroxystilbene glucoside ameliorates memory and movement functions, protects synapses and inhibits α-synuclein aggregation in hippocampus and striatum in aged mice

(2015) Cong Shen et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Tetrahydroxystilbene Glucoside Protects Against Oxidized LDL-Induced Endothelial Dysfunction via Regulating Vimentin Cytoskeleton and its Colocalization with ICAM-1 and VCAM-1

(2014) Wenjuan Yao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase

(2014) Jing Zhao et al.   IUBMB LIFE

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

(2014) Hugo González et al.   JOURNAL OF NEUROIMMUNOLOGY

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

The Effect of 2,3,4′,5-Tetrahydroxystilbene-2-O-β-D-Glucoside on Pressure Overload-Induced Cardiac Remodeling in Rats and Its Possible Mechanism

(2014) Xiao Xu et al.   PLANTA MEDICA

Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

(2013) Vanesa Sanchez-Guajardo et al.   ASN Neuro

Tetrahydroxystilbene Glucoside Attenuates Neuroinflammation through the Inhibition of Microglia Activation

(2013) Feng Zhang et al.   Oxidative Medicine and Cellular Longevity

Protective effect of tetrahydroxystilbene glucoside against d-galactose induced aging process in mice

(2013) Xuan-Xuan Zhou et al.   Phytochemistry Letters

Neuroprotection by tetrahydroxystilbene glucoside in the MPTP mouse model of Parkinson's disease

(2013) Lingling Zhang et al.   TOXICOLOGY LETTERS

Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats

(2012) WenJuan Yao et al.   BIOMEDICINE & PHARMACOTHERAPY

Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson’s disease

(2012) Xiao Wang et al.   BMC NEUROSCIENCE

Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis

(2012) Camelia S. Stancu et al.   CELL AND TISSUE RESEARCH

2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside inhibits angiotensin II-induced cardiac fibroblast proliferation via suppression of the reactive oxygen species-extracellular signal-regulated kinase 1/2 pathway

(2012) Wei Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

NADPH Oxidase and Neurodegeneration

(2012) Marina S. Hernandes et al.   Current Neuropharmacology

Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells

(2012) Jin-Kang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Profiling of phenolic constituents in Polygonum multiflorum Thunb. by combination of ultra-high-pressure liquid chromatography with linear ion trap-Orbitrap mass spectrometry

(2012) Xiaohui Qiu et al.   JOURNAL OF CHROMATOGRAPHY A

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Vascular Mechanisms in the Pathogenesis of Stroke

(2011) Cristina Sierra et al.   CURRENT HYPERTENSION REPORTS

Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity

(2011) Fang-ling Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Beneficial Effects of THSG on Acetic Acid-Induced Experimental Colitis: Involvement of Upregulation of PPAR-γ and Inhibition of the Nf-Κb Inflammatory Pathway

(2011) Cheng Zeng et al.   MOLECULES

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Protective Effect of Tetrahydroxystilbene Glucoside on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway

(2011) Lizhen Tao et al.   PLoS One

Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: The involvement of PI3K/Akt pathway activation

(2011) Rong Qin et al.   TOXICOLOGY LETTERS

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity

(2010) Ting Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

(2010) Anamitra Ghosh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation

(2010) Xiaobing Li et al.   NEUROSCIENCE LETTERS

Overexpression of HO-1 Protects against TNF-α-Mediated Airway Inflammation by Down-Regulation of TNFR1-Dependent Oxidative Stress

(2009) I-Ta Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

Reduction of Basal Forebrain Cholinergic System Parallels Cognitive Impairment in Patients at High Risk of Developing Alzheimer's Disease

(2009) M. Grothe et al.   CEREBRAL CORTEX

UPLC-PDA Analysis for Simultaneous Quantification of Four Active Compounds in Crude and Processed Rhizome of Polygonum multiflorum Thunb

(2009) Lifeng Han et al.   CHROMATOGRAPHIA

Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation

(2009) Ting Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recent advances in our understanding of neurodegeneration

(2009) Kurt A. Jellinger   JOURNAL OF NEURAL TRANSMISSION

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Effects of 2,3,4′,5-Tetrahydroxystilbene 2-O-β-D-Glucoside on Vascular Endothelial Dysfunction in Atherogenic-Diet Rats

(2009) Wei Zhang et al.   PLANTA MEDICA

Regulation of Cell Survival and Death Signals Induced by Oxidative Stress

(2008) Mikinori Kuwabara et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Differential effects of overexpression of wild-type and mutant human α-synuclein on MPP+-induced neurotoxicity in PC12 cells

(2008) Jin-Jun Qian et al.   NEUROSCIENCE LETTERS

Signalling, inflammation and arthritis: NF- B and its relevance to arthritis and inflammation

(2008) R. E. Simmonds et al.   RHEUMATOLOGY

2,3,4',5-TETRAHYDROXYSTILBENE-2-O-β-d-GLUCOSIDE SUPPRESSES MATRIX METALLOPROTEINASE EXPRESSION AND INFLAMMATION IN ATHEROSCLEROTIC RATS

(2007) Wei Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Deficiency of Inducible Nitric Oxide Synthase Protects Against MPTP Toxicity In Vivo

(2003) Thomas Dehmer et al.   JOURNAL OF NEUROCHEMISTRY