Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

The Pathophysiology of Axonal Transport in Alzheimer's Disease

(2018) Elena Vicario-Orri et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic approaches to Huntington disease: from the bench to the clinic

(2018) Nicholas S. Caron et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis

(2018) Frederick A. Zeiler et al.   Nature Reviews Neurology

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels

(2017) Annekathrin Moller et al.   HUMAN MOLECULAR GENETICS

Phosphoregulation of Tau modulates inhibition of kinesin-1 motility

(2017) Jamie L. Stern et al.   MOLECULAR BIOLOGY OF THE CELL

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration

(2017) Romain Cartoni et al.   NEURON

Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System

(2017) Josep Dalmau et al.   PHYSIOLOGICAL REVIEWS

ROS regulation of axonal mitochondrial transport is mediated by Ca2+ and JNK in Drosophila

(2017) Pin-Chao Liao et al.   PLoS One

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

(2017) Thomas S. Randall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon

(2017) Ginny G. Farías et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial multifaceted dysfunction in schizophrenia; complex I as a possible pathological target

(2017) Dorit Ben-Shachar   SCHIZOPHRENIA RESEARCH

DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca 2+ Transfer through the MAM

(2017) Sung Jin Park et al.   Cell Reports

ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak

(2017) Valentina Debattisti et al.   Cell Reports

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

(2017) Catherine M Drerup et al.   eLife

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   eLife

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

(2017) Andrew Kneynsberg et al.   Frontiers in Neuroscience

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

(2017) Natalia Salvadores et al.   Frontiers in Neuroscience

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking

(2016) Fumiaki Ogawa et al.   ACS Chemical Neuroscience

OldversusNew Mechanisms in the Pathogenesis of ALS

(2016) Simona Rossi et al.   BRAIN PATHOLOGY

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo

(2016) H. Sung et al.   JOURNAL OF NEUROSCIENCE

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

(2016) Wenzhang Wang et al.   NATURE MEDICINE

Altering the course of schizophrenia: progress and perspectives

(2016) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondria Localize to Injured Axons to Support Regeneration

(2016) Sung Min Han et al.   NEURON

Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility

(2016) Evgeny Shlevkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traumatic Axonal Injury: Mechanisms and Translational Opportunities

(2016) Ciaran S. Hill et al.   TRENDS IN NEUROSCIENCES

Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring

(2016) Cana Park et al.   Molecular Brain

Optogenetic control of organelle transport and positioning

(2015) Petra van Bergeijk et al.   NATURE

Monoamine neurotransmitter disorders—clinical advances and future perspectives

(2015) Joanne Ng et al.   Nature Reviews Neurology

Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice

(2015) Yuxiang Xie et al.   NEURON

Regulation of mitophagy in ischemic brain injury

(2015) Yang Yuan et al.   Neuroscience Bulletin

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase

(2014) Gulcin Pekkurnaz et al.   CELL

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A mitochondrial bioenergetic basis of depression

(2014) N. Jennifer Klinedinst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes

(2014) Ming Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons

(2014) Xi Lu et al.   Molecular Neurodegeneration

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms

(2014) Haijing Yan et al.   Nature Communications

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

(2013) Andrew W Ferree et al.   Autophagy

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

(2013) Fumiaki Ogawa et al.   HUMAN MOLECULAR GENETICS

Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models

(2013) Jordi Magrané et al.   HUMAN MOLECULAR GENETICS

Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

(2013) Yanmin Chen et al.   JOURNAL OF CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

(2013) Heiko Braak et al.   Nature Reviews Neurology

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering

(2012) Michelle A. Avery et al.   CURRENT BIOLOGY

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

(2012) G. M. Morotz et al.   HUMAN MOLECULAR GENETICS

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

(2011) Shengnan Wu et al.   FEBS Journal

Increased Axonal Mitochondrial Mobility Does Not Slow Amyotrophic Lateral Sclerosis (ALS)-like Disease in Mutant SOD1 Mice

(2011) Yi-Bing Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells

(2011) K. Tanaka et al.   JOURNAL OF CELL SCIENCE

The Parkinsonian Mimetic, MPP+, Specifically Impairs Mitochondrial Transport in Dopamine Axons

(2011) J. S. Kim-Han et al.   JOURNAL OF NEUROSCIENCE

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset

(2011) Christine Vande Velde et al.   PLoS One

Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons

(2011) K. T. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Defects in Mitochondrial Axonal Transport and Membrane Potential without Increased Reactive Oxygen Species Production in a Drosophila Model of Friedreich Ataxia

(2010) Y. Shidara et al.   JOURNAL OF NEUROSCIENCE

Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex

(2010) A. Misko et al.   JOURNAL OF NEUROSCIENCE

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport

(2009) Yan Li et al.   JOURNAL OF CELL BIOLOGY

Dynein Light Chain LC8 Regulates Syntaphilin-Mediated Mitochondrial Docking in Axons

(2009) Y.-M. Chen et al.   JOURNAL OF NEUROSCIENCE

Drosophila Miro Is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

(2009) G. J. Russo et al.   JOURNAL OF NEUROSCIENCE

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease

(2009) Kanae Iijima-Ando et al.   PLoS One

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

(2008) Mandana Amiri et al.   Developmental Neurobiology

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Axonal Transport Rates In Vivo Are Unaffected by Tau Deletion or Overexpression in Mice

(2008) A. Yuan et al.   JOURNAL OF NEUROSCIENCE

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Dopamine Inhibits Mitochondrial Motility in Hippocampal Neurons

(2008) Sigeng Chen et al.   PLoS One